登録情報 | データベース: PDB / ID: 3bux |
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タイトル | Crystal structure of c-Cbl-TKB domain complexed with its binding motif in c-Met |
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要素 | - 13-meric peptide from Hepatocyte growth factor receptor
- E3 ubiquitin-protein ligase CBL
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キーワード | LIGASE/SIGNALING PROTEIN / Cbl / TKB / ligase (リガーゼ) / signal transduction (シグナル伝達) / proto-oncogene (がん遺伝子) / complex / ATP-binding / Glycoprotein (糖タンパク質) / Kinase (キナーゼ) / Membrane (生体膜) / Nucleotide-binding / Phosphoprotein / Receptor / Transferase (転移酵素) / Transmembrane (膜貫通型タンパク質) / Tyrosine-protein kinase / Calcium (カルシウム) / Cytoplasm (細胞質) / Metal-binding / SH2 domain (SH2ドメイン) / Ubl conjugation pathway / Zinc (亜鉛) / Zinc-finger (ジンクフィンガー) / LIGASE-SIGNALING PROTEIN COMPLEX |
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機能・相同性 | 機能・相同性情報
regulation of platelet-derived growth factor receptor-alpha signaling pathway / ubiquitin-dependent endocytosis / regulation of Rap protein signal transduction / hepatocyte growth factor receptor activity / negative regulation of guanyl-nucleotide exchange factor activity / entry of bacterium into host cell / Drug-mediated inhibition of MET activation / endothelial cell morphogenesis / MET activates STAT3 / negative regulation of hydrogen peroxide-mediated programmed cell death ...regulation of platelet-derived growth factor receptor-alpha signaling pathway / ubiquitin-dependent endocytosis / regulation of Rap protein signal transduction / hepatocyte growth factor receptor activity / negative regulation of guanyl-nucleotide exchange factor activity / entry of bacterium into host cell / Drug-mediated inhibition of MET activation / endothelial cell morphogenesis / MET activates STAT3 / negative regulation of hydrogen peroxide-mediated programmed cell death / flotillin complex / MET interacts with TNS proteins / MET Receptor Activation / phosphatidylinositol 3-kinase regulatory subunit binding / semaphorin receptor activity / positive regulation of endothelial cell chemotaxis / MET receptor recycling / 膵臓 / MET activates PTPN11 / MET activates RAP1 and RAC1 / Sema4D mediated inhibition of cell attachment and migration / MET activates PI3K/AKT signaling / negative regulation of stress fiber assembly / negative regulation of Rho protein signal transduction / positive regulation of epidermal growth factor receptor signaling pathway / MET activates PTK2 signaling / Regulation of KIT signaling / mast cell degranulation / branching morphogenesis of an epithelial tube / positive chemotaxis / response to testosterone / Interleukin-6 signaling / negative regulation of epidermal growth factor receptor signaling pathway / response to starvation / cellular response to platelet-derived growth factor stimulus / negative regulation of thrombin-activated receptor signaling pathway / protein monoubiquitination / TGF-beta receptor signaling activates SMADs / semaphorin-plexin signaling pathway / establishment of skin barrier / protein autoubiquitination / MET activates RAS signaling / 食作用 / MECP2 regulates neuronal receptors and channels / positive regulation of microtubule polymerization / FLT3 signaling by CBL mutants / PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 / Negative regulation of FLT3 / phosphotyrosine residue binding / ephrin receptor binding / basal plasma membrane / cellular response to nerve growth factor stimulus / negative regulation of autophagy / InlB-mediated entry of Listeria monocytogenes into host cell / liver development / response to activity / molecular function activator activity / Regulation of signaling by CBL / Negative regulation of FGFR3 signaling / response to gamma radiation / Negative regulation of FGFR2 signaling / Negative regulation of FGFR4 signaling / EGFR downregulation / Negative regulation of FGFR1 signaling / Spry regulation of FGF signaling / RING-type E3 ubiquitin transferase / Constitutive Signaling by EGFRvIII / 繊毛 / Negative regulation of MET activity / receptor tyrosine kinase binding / 受容体型チロシンキナーゼ / neuron differentiation / SH3 domain binding / protein polyubiquitination / positive regulation of receptor-mediated endocytosis / cytokine-mediated signaling pathway / ubiquitin-protein transferase activity / male gonad development / cell surface receptor protein tyrosine kinase signaling pathway / Constitutive Signaling by Aberrant PI3K in Cancer / Signaling by CSF1 (M-CSF) in myeloid cells / ubiquitin protein ligase activity / 遊走 / Cargo recognition for clathrin-mediated endocytosis / PIP3 activates AKT signaling / Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants / Clathrin-mediated endocytosis / nervous system development / 成長円錐 / ubiquitin-dependent protein catabolic process / cellular response to hypoxia / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / RAF/MAP kinase cascade / protein phosphatase binding / protein tyrosine kinase activity / response to ethanol / cell surface receptor signaling pathway / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / protein ubiquitination / receptor complex類似検索 - 分子機能 Adaptor protein Cbl, N-terminal domain / Adaptor protein Cbl, N-terminal helical / Adaptor protein Cbl, EF hand-like / Adaptor protein Cbl, SH2-like domain / Adaptor protein Cbl, PTB domain / Adaptor protein Cbl / CBL proto-oncogene N-terminal domain 1 / CBL proto-oncogene N-terminus, EF hand-like domain / CBL proto-oncogene N-terminus, SH2-like domain / Cbl-type phosphotyrosine-binding (Cbl-PTB) domain profile. ...Adaptor protein Cbl, N-terminal domain / Adaptor protein Cbl, N-terminal helical / Adaptor protein Cbl, EF hand-like / Adaptor protein Cbl, SH2-like domain / Adaptor protein Cbl, PTB domain / Adaptor protein Cbl / CBL proto-oncogene N-terminal domain 1 / CBL proto-oncogene N-terminus, EF hand-like domain / CBL proto-oncogene N-terminus, SH2-like domain / Cbl-type phosphotyrosine-binding (Cbl-PTB) domain profile. / Adaptor protein Cbl, N-terminal domain superfamily / Tyrosine-protein kinase, HGF/MSP receptor / Transcription Elongation Factor S-II; Chain A / Plexin family / Plexin repeat / Plexin repeat / Sema domain / semaphorin domain / Sema domain / Sema domain superfamily / Sema domain profile. / UBA/TS-N domain / IPT/TIG domain / Ubiquitin associated domain / Zinc finger, C3HC4 RING-type / Zinc finger, C3HC4 type (RING finger) / Ubiquitin-associated domain / Ubiquitin-associated domain (UBA) profile. / ig-like, plexins, transcription factors / PSI domain / domain found in Plexins, Semaphorins and Integrins / UBA-like superfamily / SH2ドメイン / SHC Adaptor Protein / IPT domain / EFハンド / Zinc finger, RING-type, conserved site / Zinc finger RING-type signature. / Recoverin; domain 1 / 薬指 / Zinc finger RING-type profile. / Zinc finger, RING-type / SH2 domain superfamily / EF-hand domain pair / Immunoglobulin E-set / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Tyrosine-protein kinase, active site / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Zinc finger, RING/FYVE/PHD-type / WD40/YVTN repeat-like-containing domain superfamily / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Immunoglobulin-like fold / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Up-down Bundle / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 Hepatocyte growth factor receptor / E3 ubiquitin-protein ligase CBL類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.35 Å |
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データ登録者 | Ng, C. / Jackson, R.A. / Buschdorf, J.P. / Sun, Q. / Guy, G.R. / Sivaraman, J. |
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引用 | ジャーナル: Embo J. / 年: 2008 タイトル: Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates 著者: Ng, C. / Jackson, R.A. / Buschdorf, J.P. / Sun, Q. / Guy, G.R. / Sivaraman, J. |
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履歴 | 登録 | 2008年1月3日 | 登録サイト: RCSB / 処理サイト: PDBJ |
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改定 1.0 | 2008年2月26日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Version format compliance |
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改定 1.2 | 2017年10月25日 | Group: Refinement description / カテゴリ: software |
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改定 1.3 | 2023年11月1日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn / struct_ref_seq_dif Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_leaving_atom_flag / _struct_ref_seq_dif.details |
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改定 1.4 | 2023年11月15日 | Group: Data collection / カテゴリ: chem_comp_atom / chem_comp_bond / Item: _chem_comp_atom.atom_id / _chem_comp_bond.atom_id_2 |
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