登録情報 | データベース: PDB / ID: 2vrw |
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タイトル | Critical structural role for the PH and C1 domains of the Vav1 exchange factor |
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要素 | - PROTO-ONCOGENE VAV
- RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
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キーワード | SIGNALING PROTEIN / LIPOPROTEIN (リポタンパク質) / GTP-BINDING / METAL-BINDING / PROTO-ONCOGENE (がん遺伝子) / PHOSPHOPROTEIN / EXCHANGE FACTOR / RAC / VAV / GTPASE (GTPアーゼ) / MEMBRANE (生体膜) / SH2 DOMAIN (SH2ドメイン) / SH3 DOMAIN (SH3ドメイン) / METHYLATION (メチル化) / ZINC-FINGER (ジンクフィンガー) / PRENYLATION (プレニル化) / GUANINE-NUCLEOTIDE RELEASING FACTOR / PHORBOL-ESTER BINDING / ADP-RIBOSYLATION (ADPリボース化) / NUCLEOTIDE-BINDING |
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機能・相同性 | 機能・相同性情報
Azathioprine ADME / CD28 dependent Vav1 pathway / RAC2 GTPase cycle / Erythropoietin activates RAS / GPVI-mediated activation cascade / RHOA GTPase cycle / FCERI mediated MAPK activation / NRAGE signals death through JNK / Signaling by SCF-KIT / RAC1 GTPase cycle ...Azathioprine ADME / CD28 dependent Vav1 pathway / RAC2 GTPase cycle / Erythropoietin activates RAS / GPVI-mediated activation cascade / RHOA GTPase cycle / FCERI mediated MAPK activation / NRAGE signals death through JNK / Signaling by SCF-KIT / RAC1 GTPase cycle / RHOG GTPase cycle / VEGFR2 mediated vascular permeability / regulation of respiratory burst / FCERI mediated Ca+2 mobilization / phosphorylation-dependent protein binding / negative regulation of interleukin-23 production / G alpha (12/13) signalling events / regulation of neutrophil migration / localization within membrane / Activated NTRK2 signals through CDK5 / PIP3 activates AKT signaling / NADPH oxidase complex / Antigen activates B Cell Receptor (BCR) leading to generation of second messengers / negative regulation of receptor-mediated endocytosis / regulation of hydrogen peroxide metabolic process / ruffle assembly / NTRK2 activates RAC1 / Regulation of signaling by CBL / engulfment of apoptotic cell / Regulation of actin dynamics for phagocytic cup formation / Inactivation of CDC42 and RAC1 / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / WNT5:FZD7-mediated leishmania damping / SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion / Interleukin-3, Interleukin-5 and GM-CSF signaling / cortical cytoskeleton organization / respiratory burst / hepatocyte growth factor receptor signaling pathway / ruffle organization / cell projection assembly / thioesterase binding / negative regulation of fibroblast migration / VEGFA-VEGFR2 Pathway / regulation of stress fiber assembly / RHO GTPases activate CIT / Nef and signal transduction / sphingosine-1-phosphate receptor signaling pathway / regulation of nitric oxide biosynthetic process / PCP/CE pathway / motor neuron axon guidance / RHO GTPases activate KTN1 / regulation of lamellipodium assembly / positive regulation of neutrophil chemotaxis / Azathioprine ADME / Activation of RAC1 / DCC mediated attractive signaling / positive regulation of cell-substrate adhesion / MET activates RAP1 and RAC1 / Wnt signaling pathway, planar cell polarity pathway / Sema4D mediated inhibition of cell attachment and migration / CD28 dependent Vav1 pathway / Ephrin signaling / lamellipodium assembly / positive regulation of Rho protein signal transduction / establishment or maintenance of cell polarity / regulation of cell size / DSCAM interactions / Activation of RAC1 downstream of NMDARs / small GTPase-mediated signal transduction / Rho GDP-dissociation inhibitor binding / NRAGE signals death through JNK / positive regulation of natural killer cell mediated cytotoxicity / Rac protein signal transduction / RHO GTPases activate PAKs / positive regulation of focal adhesion assembly / semaphorin-plexin signaling pathway / ficolin-1-rich granule membrane / Sema3A PAK dependent Axon repulsion / EPH-ephrin mediated repulsion of cells / T cell differentiation / positive regulation of cell adhesion / RHO GTPases Activate NADPH Oxidases / RHO GTPases Activate WASPs and WAVEs / anatomical structure morphogenesis / RHO GTPases activate IQGAPs / localization / PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases / positive regulation of lamellipodium assembly / 食作用 / positive regulation of substrate adhesion-dependent cell spreading / regulation of cell migration / positive regulation of microtubule polymerization / RHO GTPases activate PKNs / positive regulation of stress fiber assembly / GPVI-mediated activation cascade / RAC1 GTPase cycle / EPHB-mediated forward signaling / reactive oxygen species metabolic process / actin filament polymerization / phosphotyrosine residue binding類似検索 - 分子機能 VAV1 protein, second SH3 domain / VAV1 protein, first SH3 domain / VAV1, SH2 domain / Vav, PH domain / Smooth muscle protein/calponin / Calmodulin-regulated spectrin-associated protein-like, Calponin-homology domain / CAMSAP CH domain / Wheat Germ Agglutinin (Isolectin 2); domain 1 - #20 / Dbl Homology Domain; Chain A / Dbl homology (DH) domain ...VAV1 protein, second SH3 domain / VAV1 protein, first SH3 domain / VAV1, SH2 domain / Vav, PH domain / Smooth muscle protein/calponin / Calmodulin-regulated spectrin-associated protein-like, Calponin-homology domain / CAMSAP CH domain / Wheat Germ Agglutinin (Isolectin 2); domain 1 - #20 / Dbl Homology Domain; Chain A / Dbl homology (DH) domain / Guanine-nucleotide dissociation stimulator, CDC24, conserved site / Dbl homology (DH) domain signature. / Wheat Germ Agglutinin (Isolectin 2); domain 1 / Small GTPase Rho / Calponin homology domain / small GTPase Rho family profile. / Phorbol esters/diacylglycerol binding domain (C1 domain) / Calponin homology domain / CH domain superfamily / Calponin homology (CH) domain profile. / Dbl homology (DH) domain superfamily / RhoGEF domain / Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases / Dbl homology (DH) domain / Dbl homology (DH) domain profile. / Zinc finger phorbol-ester/DAG-type signature. / Zinc finger phorbol-ester/DAG-type profile. / Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) / Protein kinase C-like, phorbol ester/diacylglycerol-binding domain / Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) / PH-domain like / PH domain / PH domain profile. / Pleckstrin homology domain. / Pleckstrin homology domain / Rho (Ras homology) subfamily of Ras-like small GTPases / Ras subfamily of RAS small GTPases / SH3ドメイン / 低分子量GTPアーゼ / 低分子量GTPアーゼ / Rab subfamily of small GTPases / SH2ドメイン / Src homology 2 (SH2) domain profile. / Src homology 2 domains / Src homology 3 domains / SH2ドメイン / SH2 domain superfamily / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3ドメイン / Small GTP-binding protein domain / PH-like domain superfamily / P-loop containing nucleotide triphosphate hydrolases / Roll / Up-down Bundle / P-loop containing nucleoside triphosphate hydrolase / ロスマンフォールド / 2-Layer Sandwich / 3-Layer(aba) Sandwich / Mainly Beta / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 Proto-oncogene vav / Ras-related C3 botulinum toxin substrate 1類似検索 - 構成要素 |
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生物種 | HOMO SAPIENS (ヒト) MUS MUSCULUS (ハツカネズミ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.85 Å |
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データ登録者 | Rapley, J. / Tybulewicz, V. / Rittinger, K. |
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引用 | ジャーナル: Embo Rep. / 年: 2008 タイトル: Crucial Structural Role for the Ph and C1 Domains of the Vav1 Exchange Factor. 著者: Rapley, J. / Tybulewicz, V. / Rittinger, K. |
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履歴 | 登録 | 2008年4月16日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2008年6月17日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Advisory / Version format compliance |
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