登録情報 | データベース: PDB / ID: 6jtg |
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タイトル | Structural insights into G domain dimerization and pathogenic mutations of OPA1 |
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要素 | Dynamin-like 120 kDa protein, mitochondrial,OPA1 protein |
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キーワード | HYDROLASE / Mitochondria / fusion / OPA1 |
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機能・相同性 | 機能・相同性情報
Regulation of Apoptosis / mitochondrial inner membrane fusion / membrane tubulation / GTPase-dependent fusogenic activity / membrane bending activity / inner mitochondrial membrane organization / dynamin GTPase / cristae formation / mitochondrial genome maintenance / phosphatidic acid binding ...Regulation of Apoptosis / mitochondrial inner membrane fusion / membrane tubulation / GTPase-dependent fusogenic activity / membrane bending activity / inner mitochondrial membrane organization / dynamin GTPase / cristae formation / mitochondrial genome maintenance / phosphatidic acid binding / mitochondrial fission / cardiolipin binding / positive regulation of T-helper 17 cell lineage commitment / GTP metabolic process / mitochondrial fusion / axonal transport of mitochondrion / negative regulation of release of cytochrome c from mitochondria / mitochondrial crista / positive regulation of interleukin-17 production / negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway / axon cytoplasm / visual perception / mitochondrion organization / Mitochondrial protein degradation / neural tube closure / mitochondrial membrane / cellular senescence / mitochondrial intermembrane space / protein complex oligomerization / microtubule binding / mitochondrial outer membrane / microtubule / mitochondrial inner membrane / GTPase activity / dendrite / negative regulation of apoptotic process / GTP binding / apoptotic process / magnesium ion binding / mitochondrion / nucleoplasm / membrane / cytoplasm / cytosol類似検索 - 分子機能 Dynamin-like 120kDa protein, mitochondrial / Dynamin-like GTPase OPA1, C-terminal / Dynamin-like GTPase OPA1 C-terminal / Dynamin, GTPase domain / Dynamin, GTPase / Dynamin / Dynamin-type guanine nucleotide-binding (G) domain / Dynamin-type guanine nucleotide-binding (G) domain profile. / Dynamin, N-terminal / Dynamin family / P-loop containing nucleoside triphosphate hydrolase類似検索 - ドメイン・相同性 BERYLLIUM TRIFLUORIDE ION / GUANOSINE-5'-DIPHOSPHATE / : / Dynamin-like GTPase OPA1, mitochondrial / OPA1 protein類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.4 Å |
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データ登録者 | Yan, L. / Hu, J. |
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資金援助 | 中国, 2件 組織 | 認可番号 | 国 |
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National Natural Science Foundation of China | 20171301816 | 中国 | Ministry of Science and Technology (China) | 2017YFC0840302 | 中国 |
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引用 | ジャーナル: J.Cell Biol. / 年: 2020 タイトル: Structural insights into G domain dimerization and pathogenic mutation of OPA1. 著者: Yu, C. / Zhao, J. / Yan, L. / Qi, Y. / Guo, X. / Lou, Z. / Hu, J. / Rao, Z. |
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履歴 | 登録 | 2019年4月11日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2020年4月22日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2020年5月20日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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改定 1.2 | 2024年3月27日 | Group: Data collection / Database references / Derived calculations カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / struct_conn Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id |
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