登録情報 データベース : PDB / ID : 5mja 構造の表示 ダウンロードとリンクタイトル Kinase domain of human EphB1 bound to a quinazoline-based inhibitor 要素Ephrin type-B receptor 1 詳細 キーワード TRANSFERASE / Receptor tyrosine kinase / kinase domain / Inhibitor機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
skeletal muscle satellite cell activation / hindbrain tangential cell migration / negative regulation of skeletal muscle satellite cell proliferation / optic nerve morphogenesis / negative regulation of satellite cell differentiation / axon guidance receptor activity / central nervous system projection neuron axonogenesis / transmembrane-ephrin receptor activity / immunological synapse formation / filopodium tip ... skeletal muscle satellite cell activation / hindbrain tangential cell migration / negative regulation of skeletal muscle satellite cell proliferation / optic nerve morphogenesis / negative regulation of satellite cell differentiation / axon guidance receptor activity / central nervous system projection neuron axonogenesis / transmembrane-ephrin receptor activity / immunological synapse formation / filopodium tip / dendritic spine development / camera-type eye morphogenesis / dendritic spine morphogenesis / neural precursor cell proliferation / regulation of JNK cascade / positive regulation of synapse assembly / EPH-Ephrin signaling / Ephrin signaling / establishment of cell polarity / retinal ganglion cell axon guidance / cell-substrate adhesion / detection of temperature stimulus involved in sensory perception of pain / EPH-ephrin mediated repulsion of cells / ephrin receptor signaling pathway / neurogenesis / regulation of ERK1 and ERK2 cascade / EPHB-mediated forward signaling / cell chemotaxis / axon guidance / receptor protein-tyrosine kinase / modulation of chemical synaptic transmission / early endosome membrane / angiogenesis / protein autophosphorylation / membrane raft / axon / glutamatergic synapse / dendrite / protein-containing complex binding / endoplasmic reticulum / extracellular exosome / extracellular region / ATP binding / plasma membrane / cytosol 類似検索 - 分子機能 Ephrin type-B receptor 1, ligand binding domain / EphB1 , SAM domain / : / Ephrin receptor type-A /type-B / Ephrin receptor ligand binding domain / Tyrosine-protein kinase, receptor class V, conserved site / Ephrin receptor, transmembrane domain / Ephrin receptor ligand binding domain / Ephrin type-A receptor 2 transmembrane domain / Receptor tyrosine kinase class V signature 1. ... Ephrin type-B receptor 1, ligand binding domain / EphB1 , SAM domain / : / Ephrin receptor type-A /type-B / Ephrin receptor ligand binding domain / Tyrosine-protein kinase, receptor class V, conserved site / Ephrin receptor, transmembrane domain / Ephrin receptor ligand binding domain / Ephrin type-A receptor 2 transmembrane domain / Receptor tyrosine kinase class V signature 1. / Receptor tyrosine kinase class V signature 2. / Eph receptor ligand-binding domain profile. / Ephrin receptor ligand binding domain / Putative ephrin-receptor like / SAM domain (Sterile alpha motif) / SAM domain profile. / Sterile alpha motif. / Sterile alpha motif domain / Growth factor receptor cysteine-rich domain superfamily / Sterile alpha motif/pointed domain superfamily / EGF-like domain signature 2. / Fibronectin type III domain / Fibronectin type 3 domain / Fibronectin type-III domain profile. / Galactose-binding-like domain superfamily / Fibronectin type III / Fibronectin type III superfamily / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Tyrosine-protein kinase, active site / Serine-threonine/tyrosine-protein kinase, catalytic domain / Protein tyrosine and serine/threonine kinase / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Immunoglobulin-like fold / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.14 Å 詳細データ登録者 Kung, A. / Schimpl, M. / Chen, Y.-C. / Overman, R.C. / Zhang, C. 引用ジャーナル : ACS Chem. Biol. / 年 : 2017タイトル : A Chemical-Genetic Approach to Generate Selective Covalent Inhibitors of Protein Kinases.著者 : Kung, A. / Schimpl, M. / Ekanayake, A. / Chen, Y.C. / Overman, R. / Zhang, C. 履歴 登録 2016年11月30日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2017年5月17日 Provider : repository / タイプ : Initial release改定 1.1 2017年6月28日 Group : Database references / カテゴリ : citationItem : _citation.country / _citation.journal_volume ... _citation.country / _citation.journal_volume / _citation.page_first / _citation.page_last 改定 1.2 2018年1月24日 Group : Source and taxonomy / カテゴリ : entity_src_genItem : _entity_src_gen.pdbx_host_org_ncbi_taxonomy_id / _entity_src_gen.pdbx_host_org_scientific_name / _entity_src_gen.pdbx_host_org_strain改定 1.3 2024年1月17日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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