ribosome / structural constituent of ribosome / ribonucleoprotein complex / translation Similarity search - Function
Ribosomal protein S12e signature. / Ribosomal protein S27a / 40S Ribosomal protein S10 / Plectin/S10, N-terminal / Ribosomal protein L44 / Plectin/S10 domain / Ribosomal L27e protein family / Ribosomal protein L1 signature. / Ribosomal protein S17e signature. / Ribosomal protein S28e ...Ribosomal protein S12e signature. / Ribosomal protein S27a / 40S Ribosomal protein S10 / Plectin/S10, N-terminal / Ribosomal protein L44 / Plectin/S10 domain / Ribosomal L27e protein family / Ribosomal protein L1 signature. / Ribosomal protein S17e signature. / Ribosomal protein S28e / Ribosomal protein L44e signature. / Ribosomal protein L27e signature. / Ribosomal protein L10e signature. / Ribosomal protein S7e signature. / Ribosomal protein S6e / Ribosomal L37ae protein family / Ribosomal protein S3Ae signature. / Ribosomal protein L24e signature. / Ribosomal protein L32e, conserved site / Ribosomal protein L39e signature. / Ribosomal protein L31e / Ribosomal protein S6e signature. / Ribosomal L39 protein / Ribosomal protein S28e signature. / Ribosomal protein L37e / Ribosomal L15 / Ribosomal protein L31e signature. / Ribosomal protein L1p/L10e family / Ribosomal proteins L26 eukaryotic, L24P archaeal / Ribosomal protein L32e / Ribosomal protein L32e superfamily / Ribosomal_L32e / Ribosomal protein L32e signature. / Ribosomal protein L32 / Ribosomal protein L15e signature. / Ribosomal protein L21e signature. / Ribosomal protein L37e signature. / Ribosomal protein L11 signature. / Ribosomal protein L11, N-terminal domain / Ribosomal protein L11, RNA binding domain / Ribosomal protein L7Ae/L30e/S12e/Gadd45 family / Ribosomal protein S14 signature. / Ribosomal protein L5 signature. / Ribosomal protein L5 / Ribosomal protein S4/S9 N-terminal domain / ribosomal L5P family C-terminus / Ribosomal protein L16p/L10e / Ribosomal protein S13/S18 / Ribosomal protein S14p/S29e / Ribosomal protein S7 signature. / Ribosomal protein S8 / Ribosomal protein S17 signature. / Ribosomal protein S13 signature. / Ribosomal protein S13 family profile. / Ribosomal protein S8 signature. / S4 domain / Ribosomal protein S4 signature. / Ribosomal protein S15 signature. / Ribosomal protein S7p/S5e / S4 RNA-binding domain profile. / Ribosomal protein S12/S23 / Ribosomal protein S17 / Ribosomal protein S15 / Ribosomal protein L14 signature. / Ubiquitin domain profile. / Ribosomal Proteins L2, RNA binding domain / Ribosomal protein S12 signature. / Ribosomal protein L24 signature. / Ribosomal protein L14p/L23e / KOW motif / Trp-Asp (WD) repeats signature. / WD domain, G-beta repeat / Trp-Asp (WD) repeats profile. / Trp-Asp (WD) repeats circular profile. / Winged helix-like DNA-binding domain superfamily Similarity search - Domain/homology
PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER / : / RNA / RNA (> 10) / RNA (> 100) / RNA (> 1000) / Large ribosomal subunit protein uL16 / Small ribosomal subunit protein uS4 / Large ribosomal subunit protein eL24 / Small ribosomal subunit protein eS12 ...PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER / : / RNA / RNA (> 10) / RNA (> 100) / RNA (> 1000) / Large ribosomal subunit protein uL16 / Small ribosomal subunit protein uS4 / Large ribosomal subunit protein eL24 / Small ribosomal subunit protein eS12 / Large ribosomal subunit protein eL31 / Large ribosomal subunit protein eL21 / Small ribosomal subunit protein RACK1 / Ubiquitin-ribosomal protein eS31 fusion protein / Large ribosomal subunit protein uL1 / Large ribosomal subunit protein uL11 / Small ribosomal subunit protein uS15 / Large ribosomal subunit protein uL24 / Small ribosomal subunit protein eS1 / Small ribosomal subunit protein eS7 / Large ribosomal subunit protein eL43 / Large ribosomal subunit protein eL39 / Small ribosomal subunit protein uS12 / Large ribosomal subunit protein eL42 / Large ribosomal subunit protein eL15 / Large ribosomal subunit protein uL14 / Small ribosomal subunit protein eS25 / Small ribosomal subunit protein uS7 / Small ribosomal subunit protein uS8 / Small ribosomal subunit protein eS28 / Small ribosomal subunit protein eS6 / Small ribosomal subunit protein uS13 / Plectin/eS10 N-terminal domain-containing protein / Small ribosomal subunit protein uS17 / Large ribosomal subunit protein uL2 / Small ribosomal subunit protein eS17 / Large ribosomal subunit protein uL5 / Ribosomal protein L32 / Large ribosomal subunit protein eL27 / Small ribosomal subunit protein uS14 / Large ribosomal subunit protein eL37 Similarity search - Component
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)
GM079238
United States
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)
T32 GM115327-Tan
United States
Citation
Journal: Cell Rep / Year: 2018 Title: tRNA Translocation by the Eukaryotic 80S Ribosome and the Impact of GTP Hydrolysis. Authors: Julia Flis / Mikael Holm / Emily J Rundlet / Justus Loerke / Tarek Hilal / Marylena Dabrowski / Jörg Bürger / Thorsten Mielke / Scott C Blanchard / Christian M T Spahn / Tatyana V Budkevich / Abstract: Translocation moves the tRNA⋅mRNA module directionally through the ribosome during the elongation phase of protein synthesis. Although translocation is known to entail large conformational changes ...Translocation moves the tRNA⋅mRNA module directionally through the ribosome during the elongation phase of protein synthesis. Although translocation is known to entail large conformational changes within both the ribosome and tRNA substrates, the orchestrated events that ensure the speed and fidelity of this critical aspect of the protein synthesis mechanism have not been fully elucidated. Here, we present three high-resolution structures of intermediates of translocation on the mammalian ribosome where, in contrast to bacteria, ribosomal complexes containing the translocase eEF2 and the complete tRNA⋅mRNA module are trapped by the non-hydrolyzable GTP analog GMPPNP. Consistent with the observed structures, single-molecule imaging revealed that GTP hydrolysis principally facilitates rate-limiting, final steps of translocation, which are required for factor dissociation and which are differentially regulated in bacterial and mammalian systems by the rates of deacyl-tRNA dissociation from the E site.
A2: 28S ribosomal RNA Bv: ap/P-site tRNA Bx: mRNA Bw: pe/E-site-tRNA B1: 18S ribosomal RNA BD: ribosomal protein uS3 BF: Ribosomal protein S5 BK: ribosomal protein eS10 BM: 40S ribosomal protein S12 BP: ribosomal protein uS19 BQ: ribosomal protein uS9 BR: ribosomal protein eS17 BS: ribosomal protein uS13 BT: ribosomal protein eS19 BU: ribosomal protein uS10 BZ: ribosomal protein eS25 Bc: Ribosomal protein S28 Bd: ribosomal protein uS14 Bf: Ribosomal protein S27a Bg: ribosomal protein RACK 1 BA: ribosomal protein uS2 BB: 40S ribosomal protein S3a BC: ribosomal protein uS5 BE: ribosomal protein eS4 BG: 40S ribosomal protein S6 BH: 40S ribosomal protein S7 BI: ribosomal protein eS8 BJ: Ribosomal protein S9 (Predicted) BL: Ribosomal protein S11 BN: ribosomal protein uS15 BO: ribosomal protein uS11 BV: ribosomal protein eS21 BW: Ribosomal protein S15a BX: Ribosomal protein S23 BY: ribosomal protein eS24 Ba: ribosomal protein eS26 Bb: ribosomal protein eS27 Be: ribosomal protein eS30 A3: 5.8S ribosomal RNA A4: 5S ribosomal RNA AA: Ribosomal protein L8 AB: ribosomal protein uL3 AC: ribosomal protein uL4 AD: ribosomal protein uL18 AE: ribosomal protein eL6 AF: ribosomal protein uL30 AG: ribosomal protein eL8 AH: ribosomal protein uL6 AI: Ribosomal protein L10 (Predicted) AJ: Ribosomal protein L11 AL: ribosomal protein eL13 AM: ribosomal protein eL14 AN: Ribosomal protein L15 AO: ribosomal protein uL13 AP: ribosomal protein uL22 AQ: ribosomal protein eL18 AR: ribosomal protein eL19 AS: ribosomal protein eL20 AT: ribosomal protein eL21 AU: ribosomal protein eL22 AV: Ribosomal protein L23 AW: ribosomal protein eL24 AX: ribosomal protein uL23 AY: Ribosomal protein L26 AZ: 60S ribosomal protein L27 Aa: ribosomal protein uL15 Ab: ribosomal protein eL29 Ac: ribosomal protein eL30 Ad: ribosomal protein eL31 Ae: ribosomal protein eL32 Af: ribosomal protein eL33 Ag: ribosomal protein eL34 Ah: ribosomal protein uL29 Ai: ribosomal protein eL36 Aj: Ribosomal protein L37 Ak: ribosomal protein eL38 Al: ribosomal protein eL39 Am: ribosomal protein eL40 An: ribosomal protein eL41 Ao: ribosomal protein eL42 Ap: ribosomal protein eL43 At: ribosomal protein eL28 Au: Ribosomal protein Aq: Ribosomal protein L12 AK: ribosomal protein uL10 Ct: eukaryotic elongation factor 2 (eEF2) hetero molecules
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