登録情報 データベース : PDB / ID : 6n69 構造の表示 ダウンロードとリンクタイトル rat hPGDS complexed with a quinoline 要素Hematopoietic prostaglandin D synthase 詳細 キーワード HYDROLASE / PGD2 synthase機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) / Glutathione conjugation / prostaglandin-D synthase / prostaglandin-D synthase activity / negative regulation of male germ cell proliferation / prostaglandin biosynthetic process / prostaglandin metabolic process / glutathione transferase / glutathione transferase activity / calcium ion binding ... Synthesis of Prostaglandins (PG) and Thromboxanes (TX) / Glutathione conjugation / prostaglandin-D synthase / prostaglandin-D synthase activity / negative regulation of male germ cell proliferation / prostaglandin biosynthetic process / prostaglandin metabolic process / glutathione transferase / glutathione transferase activity / calcium ion binding / magnesium ion binding / protein homodimerization activity / cytoplasm 類似検索 - 分子機能 : / Glutathione S-transferase, C-terminal domain / Glutathione S-transferase, N-terminal domain / Glutathione transferase family / Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 - #10 / Glutathione S-transferase, C-terminal / Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 / Soluble glutathione S-transferase N-terminal domain profile. / Glutathione S-transferase, C-terminal-like / Soluble glutathione S-transferase C-terminal domain profile. ... : / Glutathione S-transferase, C-terminal domain / Glutathione S-transferase, N-terminal domain / Glutathione transferase family / Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 - #10 / Glutathione S-transferase, C-terminal / Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 / Soluble glutathione S-transferase N-terminal domain profile. / Glutathione S-transferase, C-terminal-like / Soluble glutathione S-transferase C-terminal domain profile. / Glutathione S-transferase, N-terminal / Glutathione S-transferase, C-terminal domain superfamily / Glutaredoxin / Glutaredoxin / Thioredoxin-like superfamily / Up-down Bundle / 3-Layer(aba) Sandwich / Mainly Alpha / Alpha Beta 類似検索 - ドメイン・相同性 GLUTATHIONE / quinoline-3-carbonitrile / Hematopoietic prostaglandin D synthase 類似検索 - 構成要素生物種 Rattus norvegicus (ドブネズミ)手法 X線回折 / 分子置換 / 解像度 : 2 Å 詳細データ登録者 Shewchuk, L.M. / Cleasby, A. 引用ジャーナル : Bioorg. Med. Chem. / 年 : 2019タイトル : The discovery of quinoline-3-carboxamides as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors.著者: Deaton, D.N. / Do, Y. / Holt, J. / Jeune, M.R. / Kramer, H.F. / Larkin, A.L. / Orband-Miller, L.A. / Peckham, G.E. / Poole, C. / Price, D.J. / Schaller, L.T. / Shen, Y. / Shewchuk, L.M. / ... 著者 : Deaton, D.N. / Do, Y. / Holt, J. / Jeune, M.R. / Kramer, H.F. / Larkin, A.L. / Orband-Miller, L.A. / Peckham, G.E. / Poole, C. / Price, D.J. / Schaller, L.T. / Shen, Y. / Shewchuk, L.M. / Stewart, E.L. / Stuart, J.D. / Thomson, S.A. / Ward, P. / Wilson, J.W. / Xu, T. / Guss, J.H. / Musetti, C. / Rendina, A.R. / Affleck, K. / Anders, D. / Hancock, A.P. / Hobbs, H. / Hodgson, S.T. / Hutchinson, J. / Leveridge, M.V. / Nicholls, H. / Smith, I.E.D. / Somers, D.O. / Sneddon, H.F. / Uddin, S. / Cleasby, A. / Mortenson, P.N. / Richardson, C. / Saxty, G. 履歴 登録 2018年11月26日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2019年3月27日 Provider : repository / タイプ : Initial release改定 1.1 2019年4月10日 Group : Data collection / Database references / カテゴリ : citationItem : _citation.journal_volume / _citation.page_first / _citation.page_last改定 1.2 2024年3月13日 Group : Data collection / Database references / カテゴリ : chem_comp_atom / chem_comp_bond / database_2Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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