登録情報 | データベース: EMDB / ID: EMD-38387 |
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タイトル | Structure of L796778-SSTR3 G protein complex |
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マップデータ | |
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試料 | - 複合体: Structure of L796778-SSTR3 G protein complex
- タンパク質・ペプチド: Somatostatin receptor type 3
- タンパク質・ペプチド: G-alpha i
- タンパク質・ペプチド: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
- タンパク質・ペプチド: nanobody Nb35
- タンパク質・ペプチド: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
- タンパク質・ペプチド: NIT-FC0-NLE-A1D5B
- リガンド: water
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キーワード | GPCR / SSTR3 / L796778 / MEMBRANE PROTEIN |
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機能・相同性 | 機能・相同性情報
somatostatin receptor activity / hormone-mediated apoptotic signaling pathway / BBSome-mediated cargo-targeting to cilium / neuropeptide binding / non-motile cilium / cellular response to glucocorticoid stimulus / ciliary membrane / response to starvation / G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger / neuropeptide signaling pathway ...somatostatin receptor activity / hormone-mediated apoptotic signaling pathway / BBSome-mediated cargo-targeting to cilium / neuropeptide binding / non-motile cilium / cellular response to glucocorticoid stimulus / ciliary membrane / response to starvation / G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger / neuropeptide signaling pathway / forebrain development / cellular response to estradiol stimulus / Peptide ligand-binding receptors / cerebellum development / G protein-coupled receptor activity / Olfactory Signaling Pathway / Activation of the phototransduction cascade / G beta:gamma signalling through PLC beta / Presynaptic function of Kainate receptors / Thromboxane signalling through TP receptor / G protein-coupled acetylcholine receptor signaling pathway / G-protein activation / Activation of G protein gated Potassium channels / Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits / cilium / Prostacyclin signalling through prostacyclin receptor / Glucagon signaling in metabolic regulation / G beta:gamma signalling through CDC42 / ADP signalling through P2Y purinoceptor 12 / G beta:gamma signalling through BTK / Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) / Sensory perception of sweet, bitter, and umami (glutamate) taste / photoreceptor disc membrane / Adrenaline,noradrenaline inhibits insulin secretion / Glucagon-type ligand receptors / Vasopressin regulates renal water homeostasis via Aquaporins / G alpha (z) signalling events / cellular response to catecholamine stimulus / Glucagon-like Peptide-1 (GLP1) regulates insulin secretion / ADORA2B mediated anti-inflammatory cytokines production / sensory perception of taste / ADP signalling through P2Y purinoceptor 1 / adenylate cyclase-activating dopamine receptor signaling pathway / G beta:gamma signalling through PI3Kgamma / cellular response to prostaglandin E stimulus / Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding / GPER1 signaling / G-protein beta-subunit binding / Inactivation, recovery and regulation of the phototransduction cascade / heterotrimeric G-protein complex / G alpha (12/13) signalling events / extracellular vesicle / signaling receptor complex adaptor activity / Thrombin signalling through proteinase activated receptors (PARs) / GTPase binding / cell-cell signaling / retina development in camera-type eye / Ca2+ pathway / phospholipase C-activating G protein-coupled receptor signaling pathway / G alpha (i) signalling events / fibroblast proliferation / G alpha (s) signalling events / spermatogenesis / G alpha (q) signalling events / Ras protein signal transduction / Extra-nuclear estrogen signaling / cell population proliferation / neuron projection / G protein-coupled receptor signaling pathway / negative regulation of cell population proliferation / lysosomal membrane / signaling receptor binding / GTPase activity / synapse / protein-containing complex binding / signal transduction / extracellular exosome / membrane / plasma membrane / cytoplasm / cytosol類似検索 - 分子機能 Somatostatin receptor 3 / Somatostatin receptor family / Serpentine type 7TM GPCR chemoreceptor Srsx / G-protein, gamma subunit / G-protein gamma subunit domain profile. / GGL domain / G-protein gamma-like domain superfamily / G-protein gamma-like domain / GGL domain / G protein gamma subunit-like motifs ...Somatostatin receptor 3 / Somatostatin receptor family / Serpentine type 7TM GPCR chemoreceptor Srsx / G-protein, gamma subunit / G-protein gamma subunit domain profile. / GGL domain / G-protein gamma-like domain superfamily / G-protein gamma-like domain / GGL domain / G protein gamma subunit-like motifs / Guanine nucleotide-binding protein, beta subunit / G-protein, beta subunit / G-protein coupled receptors family 1 signature. / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM / G-protein coupled receptors family 1 profile. / 7 transmembrane receptor (rhodopsin family) / G-protein beta WD-40 repeat / WD40 repeat, conserved site / Trp-Asp (WD) repeats signature. / Trp-Asp (WD) repeats profile. / Trp-Asp (WD) repeats circular profile. / WD domain, G-beta repeat / WD40 repeats / WD40 repeat / WD40-repeat-containing domain superfamily / WD40/YVTN repeat-like-containing domain superfamily類似検索 - ドメイン・相同性 Somatostatin receptor type 3 / Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 / Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) / ![](img/tx_mammal.gif) Lama glama (ラマ) / synthetic construct (人工物) |
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手法 | 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 2.71 Å |
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データ登録者 | Wang Y / Xu Y / Xu HE / Zhuang Y |
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資金援助 | 中国, 1件 Organization | Grant number | 国 |
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National Natural Science Foundation of China (NSFC) | 81902085 | 中国 |
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引用 | ジャーナル: To Be Published タイトル: Selective ligand recognition and activation of somatostatin receptors SSTR1 and SSTR3 著者: Wang Y / Xu Y / He X / Fan W / Wu K / Hu W / Cheng X / Sun S / Xu HE / Zhuang Y |
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履歴 | 登録 | 2023年12月19日 | - |
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ヘッダ(付随情報) 公開 | 2024年7月3日 | - |
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マップ公開 | 2024年7月3日 | - |
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更新 | 2024年7月3日 | - |
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現状 | 2024年7月3日 | 処理サイト: PDBc / 状態: 公開 |
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