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-Structure paper
Title | Synthesis of novel glutarimide ligands for the E3 ligase substrate receptor Cereblon (CRBN): Investigation of their binding mode and antiproliferative effects against myeloma cell lines. |
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Journal, issue, pages | Eur. J. Med. Chem., Vol. 246, Page 114990-114990, Year 2023 |
Publish date | Aug 8, 2022 (structure data deposition date) |
Authors | Krasavin, M. / Adamchik, M. / Bubyrev, A. / Heim, C. / Maiwald, S. / Zhukovsky, D. / Zhmurov, P. / Bunev, A. / Hartmann, M.D. |
External links | Eur. J. Med. Chem. / PubMed:36476642 |
Methods | X-ray diffraction |
Resolution | 1.944 - 2.088 Å |
Structure data | PDB-8aop: PDB-8aoq: |
Chemicals | ChemComp-ZN: ChemComp-MW6: ChemComp-PO4: ChemComp-HOH: ChemComp-N8F: |
Source |
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Keywords | SIGNALING PROTEIN / PROTEOLYSIS TARGETING CHIMERA / PROTAC / PROTEIN DEGRADATION |