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Title | Dual antibody inhibition of KLK5 and KLK7 for Netherton syndrome and atopic dermatitis. |
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Journal, issue, pages | Sci Transl Med, Vol. 14, Page eabp9159-eabp9159, Year 2022 |
Publish date | Mar 2, 2022 (structure data deposition date) |
![]() | Chavarria-Smith, J. / Chiu, C.P.C. / Jackman, J.K. / Yin, J. / Zhang, J. / Hackney, J.A. / Lin, W.Y. / Tyagi, T. / Sun, Y. / Tao, J. ...Chavarria-Smith, J. / Chiu, C.P.C. / Jackman, J.K. / Yin, J. / Zhang, J. / Hackney, J.A. / Lin, W.Y. / Tyagi, T. / Sun, Y. / Tao, J. / Dunlap, D. / Morton, W.D. / Ghodge, S.V. / Maun, H.R. / Li, H. / Hernandez-Barry, H. / Loyet, K.M. / Chen, E. / Liu, J. / Tam, C. / Yaspan, B.L. / Cai, H. / Balazs, M. / Arron, J.R. / Li, J. / Wittwer, A.J. / Pappu, R. / Austin, C.D. / Lee, W.P. / Lazarus, R.A. / Sudhamsu, J. / Koerber, J.T. / Yi, T. |
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Methods | X-ray diffraction |
Resolution | 2.371 Å |
Structure data | ![]() PDB-7u5b: |
Chemicals | ![]() ChemComp-SO4: ![]() ChemComp-HOH: |
Source |
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![]() | HYDROLASE/IMMUNE SYSTEM / Protease / Kallikrien / KLK5 / HYDROLASE / HYDROLASE-IMMUNE SYSTEM complex |