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-Structure paper
Title | Potent and selective inhibitors of PI3K-delta: obtaining isoform selectivity from the affinity pocket and tryptophan shelf |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 22, Page 4296-4302, Year 2012 |
Publish date | May 2, 2012 (structure data deposition date) |
Authors | Sutherlin, D.P. / Baker, S. / Bisconte, A. / Blaney, P.M. / Brown, A. / Chan, B.K. / Chantry, D. / Castanedo, G. / DePledge, P. / Goldsmith, P. ...Sutherlin, D.P. / Baker, S. / Bisconte, A. / Blaney, P.M. / Brown, A. / Chan, B.K. / Chantry, D. / Castanedo, G. / DePledge, P. / Goldsmith, P. / Goldstein, D.M. / Hancox, T. / Kaur, J. / Knowles, D. / Kondru, R. / Lesnick, J. / Lucas, M.C. / Lewis, C. / Murray, J. / Nadin, A.J. / Nonomiya, J. / Pang, J. / Pegg, N. / Price, S. / Reif, K. / Safina, B.S. / Salphati, L. / Staben, S. / Seward, E.M. / Shuttleworth, S. / Sohal, S. / Sweeney, Z.K. / Ultsch, M. / Waszkowycz, B. / Wei, B. |
External links | Bioorg. Med. Chem. Lett. / PubMed:22672799 |
Methods | X-ray diffraction |
Resolution | 2.67 - 2.94 Å |
Structure data | PDB-4ezj: PDB-4ezk: PDB-4ezl: |
Chemicals | ChemComp-0SC: ChemComp-HOH: ChemComp-0SD: ChemComp-0SE: |
Source |
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Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / kinase p110 / p110-gamma / lipid kinase / cytoplasmic / TRANSFERASE-TRANSFERASE INHIBITOR complex |