タイトル | A Defined and Flexible Pocket Explains Aryl Substrate Promiscuity of the Cahuitamycin Starter Unit-Activating Enzyme CahJ. |
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ジャーナル・号・ページ | Chembiochem, Vol. 19, Page 1595-1600, Year 2018 |
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掲載日 | 2017年7月28日 (構造データの登録日) |
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著者 | Tripathi, A. / Park, S.R. / Sikkema, A.P. / Cho, H.J. / Wu, J. / Lee, B. / Xi, C. / Smith, J.L. / Sherman, D.H. |
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リンク | Chembiochem / PubMed:29742306 |
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手法 | X線回折 |
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解像度 | 1.548 - 2 Å |
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構造データ | PDB-5wm2: Crystal Structure of CahJ in Complex with Salicylic Acid and AMP 手法: X-RAY DIFFRACTION / 解像度: 1.548 Å PDB-5wm3: Crystal Structure of CahJ in Complex with Salicyl Adenylate 手法: X-RAY DIFFRACTION / 解像度: 1.679 Å PDB-5wm4: Crystal Structure of CahJ in Complex with 6-Methylsalicyl Adenylate 手法: X-RAY DIFFRACTION / 解像度: 1.781 Å PDB-5wm5: Crystal Structure of CahJ in Complex with 5-Methylsalicyl Adenylate 手法: X-RAY DIFFRACTION / 解像度: 1.797 Å PDB-5wm6: Crystal Structure of CahJ in Complex with Benzoyl Adenylate 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-5wm7: Crystal Structure of CahJ in Complex with AMP 手法: X-RAY DIFFRACTION / 解像度: 1.777 Å |
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化合物 | ChemComp-B5V: 9-(5-O-{(S)-hydroxy[(2-hydroxybenzene-1-carbonyl)oxy]phosphoryl}-alpha-L-lyxofuranosyl)-9H-purin-6-amine
ChemComp-B5M: 9-(5-O-{(S)-hydroxy[(2-hydroxy-6-methylbenzene-1-carbonyl)oxy]phosphoryl}-alpha-L-lyxofuranosyl)-9H-purin-6-amine
ChemComp-B5Y: 9-(5-O-{(S)-hydroxy[(2-hydroxy-5-methylbenzene-1-carbonyl)oxy]phosphoryl}-alpha-L-lyxofuranosyl)-9H-purin-6-amine
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由来 | streptomyces gandocaensis (バクテリア)
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キーワード | LIGASE / Adenylation Domain / Peptide Synthetase / Peptide Synthetase. |
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