タイトル | Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2. |
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ジャーナル・号・ページ | Nucleic Acids Res., Vol. 44, Page 3829-3844, Year 2016 |
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掲載日 | 2016年1月26日 (構造データの登録日) |
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著者 | Schellenberg, M.J. / Perera, L. / Strom, C.N. / Waters, C.A. / Monian, B. / Appel, C.D. / Vilas, C.K. / Williams, J.G. / Ramsden, D.A. / Williams, R.S. |
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リンク | Nucleic Acids Res. / PubMed:27060144 |
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手法 | X線回折 |
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解像度 | 1.43 - 3.205 Å |
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構造データ | PDB-5ht2: Mouse Tdp2 reaction product (5'-phosphorylated DNA)-Mg2+ complex with 1-N6-etheno-adenine 手法: X-RAY DIFFRACTION / 解像度: 1.43 Å PDB-5ink: Mouse Tdp2 reaction product (5'-phosphorylated DNA)-abasic/THF-Mg2+ complex 手法: X-RAY DIFFRACTION / 解像度: 2.15 Å PDB-5inl: Mouse Tdp2 reaction product (5'-phosphorylated DNA)-Mg2+ complex with deoxyadenosine 手法: X-RAY DIFFRACTION / 解像度: 1.551 Å PDB-5inm: Mouse Tdp2 protein, apo state with variable DNA-binding grasp conformations 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-5inn: Mouse Tdp2 D358N protein, apo state with increased disorder amongst variable DNA-binding grasp conformations 手法: X-RAY DIFFRACTION / 解像度: 2.8 Å PDB-5ino: Human Tdp2 reaction product (5'-phosphorylated DNA)-Mg2+ complex 手法: X-RAY DIFFRACTION / 解像度: 3.205 Å PDB-5inp: Mouse Tdp2 reaction product (5'-phosphorylated DNA)-Mn2+ complex 手法: X-RAY DIFFRACTION / 解像度: 1.947 Å PDB-5inq: Mouse Tdp2 reaction product (5'-phosphorylated DNA)-Ca2+ complex 手法: X-RAY DIFFRACTION / 解像度: 1.848 Å |
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化合物 | ChemComp-EPE: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / HEPES / pH緩衝剤*YM
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由来 | ![](img/tx_mammal.gif) mus musculus (ハツカネズミ)![](img/tx_bacteria.gif) escherichia coli (大腸菌) homo sapiens (ヒト)
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キーワード | hydrolase/dna / hydrolase / dna repair / endonuclease/exonuclease/phosphatase (EEP) domain / hydrolase-dna complex |
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