タイトル | Selective inhibition of biotin protein ligase from Staphylococcus aureus. |
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ジャーナル・号・ページ | J. Biol. Chem., Vol. 287, Page 17823-17832, Year 2012 |
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掲載日 | 2011年12月20日 (構造データの登録日) |
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著者 | Soares da Costa, T.P. / Tieu, W. / Yap, M.Y. / Pendini, N.R. / Polyak, S.W. / Sejer Pedersen, D. / Morona, R. / Turnidge, J.D. / Wallace, J.C. / Wilce, M.C. ...Soares da Costa, T.P. / Tieu, W. / Yap, M.Y. / Pendini, N.R. / Polyak, S.W. / Sejer Pedersen, D. / Morona, R. / Turnidge, J.D. / Wallace, J.C. / Wilce, M.C. / Booker, G.W. / Abell, A.D. |
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リンク | J. Biol. Chem. / PubMed:22437830 |
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手法 | X線回折 |
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解像度 | 2.1 - 3.23 Å |
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構造データ | PDB-3v7c: Cystal structure of SaBPL in complex with inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.7 Å PDB-3v7r: Crystal structure of Staphylococcus aureus biotin protein ligase in complex with inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.61 Å PDB-3v7s: Crystal structure of Staphylococcus aureus biotin protein ligase in complex with inhibitor 0364 手法: X-RAY DIFFRACTION / 解像度: 3.1 Å PDB-3v8j: Crystal structure of Staphylococcus aureus biotin protein ligase 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-3v8k: Crystal structure of Staphylococcus aureus biotin protein ligase in complex with biotin 手法: X-RAY DIFFRACTION / 解像度: 3.23 Å PDB-3v8l: Crystal structure of Staphylococcus aureus biotin protein ligase in complex with biotinyl-5'-AMP 手法: X-RAY DIFFRACTION / 解像度: 2.6 Å PDB-4dq2: Structure of staphylococcus aureus biotin protein ligase in complex with biotinol-5'-amp 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å |
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化合物 | ChemComp-C77: 5'-deoxy-2',3'-O-(1-methylethylidene)-5'-(4-{5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentyl}-1H-1,2,3-triazol-1-yl)adenosine
ChemComp-32G: (3aS,4S,6aR)-4-(5-{1-[4-(6-amino-9H-purin-9-yl)butyl]-1H-1,2,3-triazol-4-yl}pentyl)tetrahydro-1H-thieno[3,4-d]imidazol-2(3H)-one
ChemComp-36F: 5-methyl-3-[4-(4-{5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentyl}-1H-1,2,3-triazol-1-yl)butyl]-1,3-benzoxazol-2(3H)-one
ChemComp-BTX: ((2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXY-TETRAHYDROFURAN-2-YL)METHYL 5-((3AS,4S,6AR)-2-OXO-HEXAHYDRO-1H-THIENO[3,4-D]IMIDAZOL-4-YL)PENTYL HYDROGEN PHOSPHATE / 5′-アデニル酸5-[(3aS,4S,6aR)-ヘキサヒドロ-2-オキソ-1H-チエノ[3,4-d]イミダゾ-ル-4-(以下略)
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由来 | - staphylococcus aureus (黄色ブドウ球菌)
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キーワード | LIGASE/LIGASE INHIBITOR / biotin / metabolism / biotin carboxyl carrier protein / LIGASE-LIGASE INHIBITOR complex / biotin protein ligase / LIGASE / DNA binding domain / ligate |
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