タイトル | Fragment-Based Discovery of Mexiletine Derivatives as Orally Bioavailable Inhibitors of Urokinase-Type Plasminogen Activator |
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ジャーナル・号・ページ | J. Med. Chem., Vol. 51, Page 183-, Year 2008 |
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掲載日 | 2007年12月5日 (構造データの登録日) |
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著者 | Frederickson, M. / Callaghan, O. / Chessari, G. / Congreve, M. / Cowan, S.R. / Matthews, J.E. / Mcmenamin, R. / Smith, D. / Vinkovic, M. / Wallis, N.G. |
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リンク | J. Med. Chem. / PubMed:18163548 |
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手法 | X線回折 |
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解像度 | 1.72 - 2.05 Å |
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構造データ | PDB-2vin: Fragment-Based Discovery of Mexiletine Derivatives as Orally Bioavailable Inhibitors of Urokinase-Type Plasminogen Activator 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-2vio: Fragment-Based Discovery of Mexiletine Derivatives as Orally Bioavailable Inhibitors of Urokinase-Type Plasminogen Activator 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-2vip: Fragment-Based Discovery of Mexiletine Derivatives as Orally Bioavailable Inhibitors of Urokinase-Type Plasminogen Activator 手法: X-RAY DIFFRACTION / 解像度: 1.72 Å PDB-2viq: Fragment-Based Discovery of Mexiletine Derivatives as Orally Bioavailable Inhibitors of Urokinase-Type Plasminogen Activator 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-2viv: Fragment-Based Discovery of Mexiletine Derivatives as Orally Bioavailable Inhibitors of Urokinase-Type Plasminogen Activator 手法: X-RAY DIFFRACTION / 解像度: 1.72 Å PDB-2viw: Fragment-Based Discovery of Mexiletine Derivatives as Orally Bioavailable Inhibitors of Urokinase-Type Plasminogen Activator 手法: X-RAY DIFFRACTION / 解像度: 2.05 Å |
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化合物 | ChemComp-L1O: 4-(2-aminoethoxy)-3,5-dichlorobenzoic acid
ChemComp-L1R: 4-(2-AMINOETHOXY)-3,5-DICHLORO-N-[3-(1-METHYLETHOXY)PHENYL]BENZAMIDE
ChemComp-D55: 4-(2-aminoethoxy)-N-(2,5-diethoxyphenyl)-3,5-dimethylbenzamide
ChemComp-VG2: 4-(2-aminoethoxy)-N-(3-chloro-5-piperidin-1-ylphenyl)-3,5-dimethylbenzamide
ChemComp-D56: 4-(2-aminoethoxy)-N-(3-chloro-2-ethoxy-5-piperidin-1-ylphenyl)-3,5-dimethylbenzamide
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由来 | homo sapiens (ヒト)
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キーワード | HYDROLASE / PLASMINOGEN ACTIVATION / EGF-LIKE DOMAIN / BLOOD COAGULATION / INHIBITOR / POLYMORPHISM / GLYCOPROTEIN / FIBRINOLYSIS / KRINGLE / ZYMOGEN / SECRETED / PROTEASE / UROKINASE-TYPE PLASMINOGEN ACTIVATOR / PHARMACEUTICAL / SERINE PROTEASE / PHOSPHORYLATION |
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