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-Structure paper
Title | Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development. |
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Journal, issue, pages | Proc. Natl. Acad. Sci. USA, Vol. 105, Page 1448-1453, Year 2008 |
Publish date | Jul 3, 2007 (structure data deposition date) |
Authors | Cavazzuti, A. / Paglietti, G. / Hunter, W.N. / Gamarro, F. / Piras, S. / Loriga, M. / Allecca, S. / Corona, P. / McLuskey, K. / Tulloch, L. ...Cavazzuti, A. / Paglietti, G. / Hunter, W.N. / Gamarro, F. / Piras, S. / Loriga, M. / Allecca, S. / Corona, P. / McLuskey, K. / Tulloch, L. / Gibellini, F. / Ferrari, S. / Costi, M.P. |
External links | Proc. Natl. Acad. Sci. USA / PubMed:18245389 |
Methods | X-ray diffraction |
Resolution | 2.4 - 2.61 Å |
Structure data | PDB-2qhx: PDB-3h4v: |
Chemicals | ChemComp-IOD: ChemComp-NAP: ChemComp-FE1: ChemComp-HOH: ChemComp-DVP: |
Source |
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Keywords | OXIDOREDUCTASE / short-chain dehydrogenase/reductase / pteridine reductase / trypanosomatid / pterin salvage / drug resistance / methotrexate resistance / enzyme inhibitor / NADP/NADPH / SHORT-CHAIN REDUCTASE / LEISHMANIA / TRYPANOSOMA / PTR1 / INHIBITOR / NADP |