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Structure paper

TitleIn situ structural mechanism of epothilone-B-induced CNS axon regeneration
Journal, issue, pagesNature, Year 2025
Publish dateJul 20, 2025 (structure data deposition date)
AuthorsBodakuntla S / Taira K / Yamada Y / Alvarez-Brecht P / Cada AK / Basnet N / Zhang R / Martinez-Sanchez A / Biertumpfel C / Mizuno N
External linksNature / Search PubMed
MethodsEM (helical sym.)
Resolution3.19 Å
Structure data

71750

9pnd

EMDB-71750, PDB-9pnd:
In situ microtubule of EpoB-induced regenerating axons
Method: EM (helical sym.) / Resolution: 3.19 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

ChemComp-EPB:
7,11-DIHYDROXY-8,8,10,12,16-PENTAMETHYL-3-[1-METHYL-2-(2-METHYL-THIAZOL-4-YL)VINYL]-4,17-DIOXABICYCLO[14.1.0]HEPTADECANE-5,9-DIONE

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP, energy-carrying molecule*YM

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
KeywordsSTRUCTURAL PROTEIN / cytoskeleton / microtubules / neuroregeneration / axon

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