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TitleStructure-Guided Design of Affinity/Covalent-Bond Dual-Driven Inhibitors Targeting the AMP Site of FBPase
Journal, issue, pagesJ. Med. Chem., Year 2024
Publish dateDec 6, 2023 (structure data deposition date)
AuthorsCao, H. / Huang, Z. / Liu, Z. / Zhang, X. / Ren, Y. / Hameed, M.S. / Rao, L. / Makunga, N.P. / Dobrikov, G.M. / Wan, J.
External linksJ. Med. Chem. / Search PubMed
MethodsX-ray diffraction
Resolution2.42 Å
Structure data

PDB-8xbk:
Crystal Structure of Human Liver Fructose-1,6-bisphosphatase Complexed with a Covalent Inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.42 Å

Chemicals


ChemComp, No image

ChemComp-YR9:
Unknown entry

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsPROTEIN BINDING / covalent inhibitor

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