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-Structure paper
Title | An allosteric inhibitor of sirtuin 2 deacetylase activity exhibits broad-spectrum antiviral activity. |
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Journal, issue, pages | J. Clin. Invest., Vol. 133, Year 2023 |
Publish date | Dec 1, 2021 (structure data deposition date) |
![]() | Roche, K.L. / Remiszewski, S. / Todd, M.J. / Kulp 3rd, J.L. / Tang, L. / Welsh, A.V. / Barry, A.P. / De, C. / Reiley, W.W. / Wahl, A. ...Roche, K.L. / Remiszewski, S. / Todd, M.J. / Kulp 3rd, J.L. / Tang, L. / Welsh, A.V. / Barry, A.P. / De, C. / Reiley, W.W. / Wahl, A. / Garcia, J.V. / Luftig, M.A. / Shenk, T. / Tonra, J.R. / Murphy, E.A. / Chiang, L.W. |
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Methods | X-ray diffraction |
Resolution | 1.75 Å |
Structure data | ![]() PDB-7t1d: |
Chemicals | ![]() ChemComp-ZN: ![]() ChemComp-SO4: ![]() ChemComp-EDO: ![]() ChemComp-DMS: ![]() ChemComp-E7K: ![]() ChemComp-HOH: |
Source |
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![]() | HYDROLASE/INHIBITOR / Allosteric inhibitor / HYDROLASE / HYDROLASE-INHIBITOR complex |