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TitleUnexpected Receptor Functional Mimicry Elucidates Activation of Coronavirus Fusion.
Journal, issue, pagesCell, Vol. 176, Issue 5, Page 1026-1039.e15, Year 2019
Publish dateFeb 21, 2019
AuthorsAlexandra C Walls / Xiaoli Xiong / Young-Jun Park / M Alejandra Tortorici / Joost Snijder / Joel Quispe / Elisabetta Cameroni / Robin Gopal / Mian Dai / Antonio Lanzavecchia / Maria Zambon / Félix A Rey / Davide Corti / David Veesler
External linksPubMed:30712865 / Publisher's page
KeywordsVIRUS / coronavirus spike glycoprotein / MERS-CoV / SARS-CoV / human neutralizing antibodies / Structural Genomics / Seattle Structural Genomics Center for Infectious Disease / SSGCID / IMMUNE SYSTEM / Fab / Coronavirus / Glycoprotein / SARS
MethodsEM (single particle) / X-ray diffraction
Resolution1.5 - 4.5 A
Structure data

EMDB-0401:
MERS-CoV complex with human neutralizing LCA60 antibody Fab fragment (state 1)

EMDB-0402:
MERS-CoV S complex with human neutralizing LCA60 antibody Fab fragment (state 2)

EMDB-0403:
SARS-CoV complex with human neutralizing S230 antibody Fab fragment (state 1)

EMDB-0404:
SARS-CoV complex with human neutralizing S230 antibody Fab fragment (state 2)

PDB-6nb3:
MERS-CoV complex with human neutralizing LCA60 antibody Fab fragment (state 1)

PDB-6nb4:
MERS-CoV S complex with human neutralizing LCA60 antibody Fab fragment (state 2)

PDB-6nb5:
Crystal structure of anti- MERS-CoV human neutralizing LCA60 antibody Fab fragment

PDB-6nb6:
SARS-CoV complex with human neutralizing S230 antibody Fab fragment (state 1)

PDB-6nb7:
SARS-CoV complex with human neutralizing S230 antibody Fab fragment (state 2)

PDB-6nb8:
Crystal structure of anti- SARS-CoV human neutralizing S230 antibody Fab fragment

Chemicals

ChemComp-NAG:
N-ACETYL-D-GLUCOSAMINEN-Acetylglucosamine

ChemComp-BMA:
BETA-D-MANNOSE

ChemComp-MAN:
ALPHA-D-MANNOSE

ChemComp-HOH:
WATERWater

Source
  • Middle East respiratory syndrome coronavirus
  • Middle East respiratory syndrome-related coronavirus
  • Homo sapiens (human)
  • SARS coronavirus
  • middle east respiratory syndrome-related coronavirus
  • homo sapiens (human)
  • middle east respiratory syndrome coronavirus
  • sars coronavirus

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