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Structure paper

TitleCryo-EM structure of the human α1β3γ2 GABA receptor in a lipid bilayer.
Journal, issue, pagesNature, Year 2019
Publish dateJan 2, 2019
AuthorsDuncan Laverty / Rooma Desai / Tomasz Uchański / Simonas Masiulis / Wojciech J Stec / Tomas Malinauskas / Jasenko Zivanov / Els Pardon / Jan Steyaert / Keith W Miller / A Radu Aricescu
External linksPubMed:30602789 / Publisher's page
KeywordsTRANSPORT PROTEIN / Ligand gated ion channel Cys-Loop receptor GABA-A receptor
MethodsEM (single particle)
Resolution3.2 A
Structure data

EMDB-4411:
Cryo-EM structure of the human synaptic alpha1-beta3-gamma2 GABAA receptor in complex with Megabody38 in a lipid nanodisc

PDB-6i53:
Cryo-EM structure of the human synaptic alpha1-beta3-gamma2 GABAA receptor in complex with Megabody38 in a lipid nanodisc

Chemicals

ChemComp-NAG:
N-ACETYL-D-GLUCOSAMINEN-Acetylglucosamine

ChemComp-BMA:
BETA-D-MANNOSE

ChemComp-MAN:
ALPHA-D-MANNOSE

ChemComp-POV:
(2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphatePOPC

ChemComp-PIO:
[(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate

Source
  • Homo sapiens (human)
  • Lama glama (llama)
  • homo sapiens (human)
  • lama glama (llama)

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Feb 20, 2018. PDBj/BINDS workshop in Osaka University

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    Oct 4, 2017. Three pioneers of this field were awarded Nobel Prize in Chemistry 2017

    Three pioneers of this field were awarded Nobel Prize in Chemistry 2017

    • Jacques Dubochet (University of Lausanne, Switzerland) is a pioneer of ice-embedding method of EM specimen (as known as cryo-EM), Most of 3DEM structures in EMDB and PDB are obtained using his method.
    • Joachim Frank (Columbia University, New York, USA) is a pioneer of single particle reconstruction, which is the most used reconstruction method for 3DEM structures in EMDB and EM entries in PDB. And also, he is a develper of Spider, which is one of the most famous software in this field, and is used for some EM Navigor data (e.g. map projection/slice images).
    • Richard Henderson (MRC Laboratory of Molecular Biology, Cambridge, UK) was determined the first biomolecule structure by EM. The first EM entry in PDB, PDB-1brd is determinedby him.

    External links: The 2017 Nobel Prize in Chemistry - Press Release

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    External links: wwPDB Remediation / Enriched Model Files Conforming to OneDep Data Standards Now Available in the PDB FTP Archive

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    EMN Papers

    Database of articles cited by 3DEM data entries

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