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Structure paper

TitleStructural basis of Notch recognition by human γ-secretase.
Journal, issue, pagesNature, Vol. 565, Issue 7738, Page 192-197, Year 2019
Publish dateDec 31, 2018
AuthorsGuanghui Yang / Rui Zhou / Qiang Zhou / Xuefei Guo / Chuangye Yan / Meng Ke / Jianlin Lei / Yigong Shi
External linksPubMed:30598546 / Publisher's page
KeywordsMEMBRANE PROTEIN / complex
MethodsEM (single particle)
Resolution2.7 A
Structure data

EMDB-9648:
Cryo-EM structure of gamma secretase in complex with a Notch fragment

PDB-6idf:
Cryo-EM structure of gamma secretase in complex with a Notch fragment

Chemicals

ChemComp-NAG:
N-ACETYL-D-GLUCOSAMINEN-Acetylglucosamine

ChemComp-BMA:
BETA-D-MANNOSE

ChemComp-PC1:
1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE

ChemComp-CLR:
CHOLESTEROLCholesterol

Source
  • Homo sapiens (human)
  • homo sapiens (human)

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About EMN Papers

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News

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Feb 20, 2018. PDBj/BINDS workshop in Osaka University

PDBj/BINDS workshop in Osaka University

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    Oct 4, 2017. Three pioneers of this field were awarded Nobel Prize in Chemistry 2017

    Three pioneers of this field were awarded Nobel Prize in Chemistry 2017

    • Jacques Dubochet (University of Lausanne, Switzerland) is a pioneer of ice-embedding method of EM specimen (as known as cryo-EM), Most of 3DEM structures in EMDB and PDB are obtained using his method.
    • Joachim Frank (Columbia University, New York, USA) is a pioneer of single particle reconstruction, which is the most used reconstruction method for 3DEM structures in EMDB and EM entries in PDB. And also, he is a develper of Spider, which is one of the most famous software in this field, and is used for some EM Navigor data (e.g. map projection/slice images).
    • Richard Henderson (MRC Laboratory of Molecular Biology, Cambridge, UK) was determined the first biomolecule structure by EM. The first EM entry in PDB, PDB-1brd is determinedby him.

    External links: The 2017 Nobel Prize in Chemistry - Press Release

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    Jul 12, 2017. Major update of PDB

    Major update of PDB

    • wwPDB released updated PDB data conforming to the new PDBx/mmCIF dictionary. This is a major update changing the version number from 4 to 5, and with Remediation, in which all the entries are updated. See below links for details.
    • In this update, many items about electron microscopy experimental information are reorganized (e.g. em_software). Now, EM Navigator and Yorodumi are based on the updated data.

    External links: wwPDB Remediation / Enriched Model Files Conforming to OneDep Data Standards Now Available in the PDB FTP Archive

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    Jun 16, 2017. Omokage search with filter

    Omokage search with filter

    • Result of Omokage search can be filtered by keywords and the database types

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    Sep 15, 2016. EM Navigator & Yorodumi renewed

    EM Navigator & Yorodumi renewed

    • New versions of EM Navigator and Yorodumi started

    Related info.: Changes in new EM Navigator and Yorodumi

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    EMN Papers

    Database of articles cited by 3DEM data entries

    • Database of articles cited by 3DEM data entries in EMDB and PDB
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    Related info.: EMDB / PDB / Q: What is the data source of EM Navigator? / EM Navigator / Yorodumi Papers / Changes in new EM Navigator and Yorodumi

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