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Structure paper

TitleCryo-EM structure of a fungal mitochondrial calcium uniporter.
Journal, issue, pagesNature, Vol. 559, Issue 7715, Page 570-574, Year 2018
Publish dateJul 11, 2018
AuthorsNam X Nguyen / Jean-Paul Armache / Changkeun Lee / Yi Yang / Weizhong Zeng / Vamsi K Mootha / Yifan Cheng / Xiao-Chen Bai / Youxing Jiang
External linksPubMed:29995855 / Publisher's page
KeywordsTRANSPORT PROTEIN / Mitochondria / calcium channel
MethodsEM (single particle)
Resolution3.8 - 5 A
Structure data

EMDB-7826:
Cryo-EM structure of the mitochondrial calcium uniporter from N. fischeri at 3.8 Angstrom resolution

EMDB-7828:
Cryo-EM structure of the mitochondrial calcium uniporter from N. fischeri bound to saposin

PDB-6d7w:
Cryo-EM structure of the mitochondrial calcium uniporter from N. fischeri at 3.8 Angstrom resolution

PDB-6d80:
Cryo-EM structure of the mitochondrial calcium uniporter from N. fischeri bound to saposin

Chemicals

ChemComp-CA:
CALCIUM IONCalcium

Source
  • Aspergillus fischeri (mold)
  • Homo sapiens (human)
  • aspergillus fischeri (mold)
  • homo sapiens (human)

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    Oct 4, 2017. Three pioneers of this field were awarded Nobel Prize in Chemistry 2017

    Three pioneers of this field were awarded Nobel Prize in Chemistry 2017

    • Jacques Dubochet (University of Lausanne, Switzerland) is a pioneer of ice-embedding method of EM specimen (as known as cryo-EM), Most of 3DEM structures in EMDB and PDB are obtained using his method.
    • Joachim Frank (Columbia University, New York, USA) is a pioneer of single particle reconstruction, which is the most used reconstruction method for 3DEM structures in EMDB and EM entries in PDB. And also, he is a develper of Spider, which is one of the most famous software in this field, and is used for some EM Navigor data (e.g. map projection/slice images).
    • Richard Henderson (MRC Laboratory of Molecular Biology, Cambridge, UK) was determined the first biomolecule structure by EM. The first EM entry in PDB, PDB-1brd is determinedby him.

    External links: The 2017 Nobel Prize in Chemistry - Press Release

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