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Structure paper

TitleAtomic-level evidence for packing and positional amyloid polymorphism by segment from TDP-43 RRM2.
Journal, issue, pagesNat. Struct. Mol. Biol., Vol. 25, Issue 4, Page 311-319, Year 2018
Publish date--
AuthorsElizabeth L Guenther / Peng Ge / Hamilton Trinh / Michael R Sawaya / Duilio Cascio / David R Boyer / Tamir Gonen / Z Hong Zhou / David S Eisenberg
External linksPubMed:29531287 / Publisher's page
KeywordsPROTEIN FIBRIL / Amyloid / steric zipper
MethodsEM (electron crystallography) / EM (helical sym.) / X-ray diffraction
Resolution1.4 - 3.8 A
Structure data

EMDB-8765:
MicroED structure of the segment, DLIIKGISVHI, from the RRM2 of TDP-43, residues 247-257

EMDB-8781:
CryoEM structure of the segment, DLIIKGISVHI, assembled into a triple-helical fibril

PDB-5w50:
Crystal structure of the segment, LIIKGI, from the RRM2 of TDP-43, residues 248-253

PDB-5w52:
MicroED structure of the segment, DLIIKGISVHI, from the RRM2 of TDP-43, residues 247-257

PDB-5w7v:
CryoEM structure of the segment, DLIIKGISVHI, assembled into a triple-helical fibril

Chemicals

ChemComp-HOH:
WATERWater

Source
  • Homo sapiens (human)
  • homo sapiens (human)

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