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Structure paper

TitleGating mechanisms of acid-sensing ion channels.
Journal, issue, pagesNature, Vol. 555, Issue 7696, Page 397-401, Year 2018
Publish dateMar 15, 2018
AuthorsNate Yoder / Craig Yoshioka / Eric Gouaux
External linksPubMed:29513651 / Publisher's page
KeywordsAcid Sensing Ion Channels / Animals / Binding Sites / CHO Cells / Chickens / Cricetulus / Cryoelectron Microscopy / Crystallography, X-Ray / HEK293 Cells / Humans / Hydrogen-Ion Concentration / Ion Channel Gating / Models, Molecular / Protein Domains / Protons / Sf9 Cells / Spodoptera / TRANSPORT PROTEIN / Ion channel / ASIC / ASIC1a / Sodium channel / MEMBRANE PROTEIN
MethodsEM (single particle) / X-ray diffraction
Resolution2.95 - 3.7 A
Structure data

EMDB-7009:
Structure of an acid sensing ion channel in a resting state at high pH

PDB-5wku:
Structure of an acid sensing ion channel in a resting state with barium

PDB-5wkv:
Structure of an acid sensing ion channel in a resting state with calcium

PDB-6ave:
Structure of an acid sensing ion channel in a resting state at high pH

Chemicals

ChemComp-NAG:
N-ACETYL-D-GLUCOSAMINEN-Acetylglucosamine

ChemComp-CL:
CHLORIDE IONChloride

ChemComp-BA:
BARIUM IONBarium

ChemComp-CA:
CALCIUM IONCalcium

Source
  • Gallus (bird)
  • Gallus gallus (chicken)
  • gallus gallus (chicken)

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    Three pioneers of this field were awarded Nobel Prize in Chemistry 2017

    • Jacques Dubochet (University of Lausanne, Switzerland) is a pioneer of ice-embedding method of EM specimen (as known as cryo-EM), Most of 3DEM structures in EMDB and PDB are obtained using his method.
    • Joachim Frank (Columbia University, New York, USA) is a pioneer of single particle reconstruction, which is the most used reconstruction method for 3DEM structures in EMDB and EM entries in PDB. And also, he is a develper of Spider, which is one of the most famous software in this field, and is used for some EM Navigor data (e.g. map projection/slice images).
    • Richard Henderson (MRC Laboratory of Molecular Biology, Cambridge, UK) was determined the first biomolecule structure by EM. The first EM entry in PDB, PDB-1brd is determinedby him.

    External links: The 2017 Nobel Prize in Chemistry - Press Release

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    EMN Papers

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