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Structure paper

TitleStructural Basis of Substrate Recognition by the Multidrug Resistance Protein MRP1.
Journal, issue, pagesCell, Vol. 168, Issue 6, Page 1075-1085.e9, Year 2017
Publish dateMar 9, 2017
AuthorsZachary Lee Johnson / Jue Chen
External linksPubMed:28238471 / Publisher's page
MethodsEM (single particle)
Resolution3.34 - 3.49 A
Structure data

EMDB-8559:
Cryo-EM structure of bovine multidrug resistance protein 1 (MRP1)

EMDB-8560:
Cryo-EM structure of bovine multidrug resistance protein 1 (MRP1) bound to leukotriene C4

PDB-5uj9:
Cryo-EM structure of bovine multidrug resistance protein 1 (MRP1)

PDB-5uja:
Cryo-EM structure of bovine multidrug resistance protein 1 (MRP1) bound to leukotriene C4

Chemicals

ChemComp-LTX:
(5~{S},6~{R},7~{E},9~{E},11~{Z},14~{Z})-6-[(2~{R})-2-[[(4~{S})-4-azanyl-5-oxidanyl-5-oxidanylidene-pentanoyl]amino]-3-(2-hydroxy-2-oxoethylamino)-3-oxidanylidene-propyl]sulfanyl-5-oxidanyl-icosa-7,9,11,14-tetraenoic acid

SourceBos taurus / mammal / ウシ /
KeywordsAdenosine Triphosphate / Animals / Cattle / Cryoelectron Microscopy / Drug Resistance, Multiple / HEK293 Cells / Humans / Hydrolysis / Mice / Models, Molecular / Multidrug Resistance-Associated Proteins / P-Glycoprotein / Protein Domains / Sf9 Cells / multidrug resistance-associated protein 1 / TRANSPORT PROTEIN / ABC transporter / multidrug resistance / PROTEIN TRANSPORT / leukotriene C4 / LTC4

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Oct 4, 2017. Three pioneers of this field were awarded Nobel Prize in Chemistry 2017

Three pioneers of this field were awarded Nobel Prize in Chemistry 2017

  • Jacques Dubochet (University of Lausanne, Switzerland) is a pioneer of ice-embedding method of EM specimen (as known as cryo-EM), Most of 3DEM structures in EMDB and PDB are obtained using his method.
  • Joachim Frank (Columbia University, New York, USA) is a pioneer of single particle reconstruction, which is the most used reconstruction method for 3DEM structures in EMDB and EM entries in PDB. And also, he is a develper of Spider, which is one of the most famous software in this field, and is used for some EM Navigor data (e.g. map projection/slice images).
  • Richard Henderson (MRC Laboratory of Molecular Biology, Cambridge, UK) was determined the first biomolecule structure by EM. The first EM entry in PDB, PDB-1brd is determinedby him.

External links: The 2017 Nobel Prize in Chemistry - Press Release

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