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Structure paper

TitleOpening of the human epithelial calcium channel TRPV6.
Journal, issue, pagesNature, Vol. 553, Issue 7687, Page 233-237, Year 2018
Publish dateDec 20, 2017
AuthorsLuke L McGoldrick / Appu K Singh / Kei Saotome / Maria V Yelshanskaya / Edward C Twomey / Robert A Grassucci / Alexander I Sobolevsky
External linksPubMed:29258289 / Publisher's page
MethodsEM (single particle)
Resolution3.6 - 4.2 A
Structure data

EMDB-7120:
Cryo-EM structure of human TRPV6 in nanodiscs

EMDB-7121:
Cryo-EM structure of human TRPV6 in amphipols

EMDB-7122:
Cryo-EM structure of human TRPV6-R470E in amphipols

EMDB-7123:
Cryo-EM structure of rat TRPV6* in nanodiscs

PDB-6bo8:
Cryo-EM structure of human TRPV6 in nanodiscs

PDB-6bo9:
Cryo-EM structure of human TRPV6 in amphipols

PDB-6boa:
Cryo-EM structure of human TRPV6-R470E in amphipols

PDB-6bob:
Cryo-EM structure of rat TRPV6* in nanodiscs

SourceHomo sapiens / human
Rattus norvegicus / mammal / ドブネズミ, どぶねずみ /
KeywordsTRANSPORT PROTEIN / Ion channel / Membrane protein

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Oct 4, 2017. Three pioneers of this field were awarded Nobel Prize in Chemistry 2017

Three pioneers of this field were awarded Nobel Prize in Chemistry 2017

  • Jacques Dubochet (University of Lausanne, Switzerland) is a pioneer of ice-embedding method of EM specimen (as known as cryo-EM), Most of 3DEM structures in EMDB and PDB are obtained using his method.
  • Joachim Frank (Columbia University, New York, USA) is a pioneer of single particle reconstruction, which is the most used reconstruction method for 3DEM structures in EMDB and EM entries in PDB. And also, he is a develper of Spider, which is one of the most famous software in this field, and is used for some EM Navigor data (e.g. map projection/slice images).
  • Richard Henderson (MRC Laboratory of Molecular Biology, Cambridge, UK) was determined the first biomolecule structure by EM. The first EM entry in PDB, PDB-1brd is determinedby him.

External links: The 2017 Nobel Prize in Chemistry - Press Release

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Jul 12, 2017. Major update of PDB

Major update of PDB

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External links: wwPDB Remediation / Enriched Model Files Conforming to OneDep Data Standards Now Available in the PDB FTP Archive

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EMN Papers

Database of articles cited by 3DEM data entries

  • Database of articles cited by 3DEM data entries in EMDB and PDB
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