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Structure paper

TitleCryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states.
Journal, issue, pagesNat. Struct. Mol. Biol., Vol. 24, Issue 12, Page 1146-1154, Year 2017
Publish date--
AuthorsXiaoyuan Zhou / Minghui Li / Deyuan Su / Qi Jia / Huan Li / Xueming Li / Jian Yang
External linksPubMed:29106414 / Publisher's page
MethodsEM (single particle)
Resolution3.62 - 4.65 A
Structure data

EMDB-7019:
TRPML3/ML-SA1 complex at pH 7.4

EMDB-7020:
Human Apo-TRPML3 channel at pH 4.8

EMDB-7018:
Human apo-TRPML3 channel at pH 7.4

PDB-6aye:
Human apo-TRPML3 channel at pH 7.4

PDB-6ayf:
TRPML3/ML-SA1 complex at pH 7.4

PDB-6ayg:
Human Apo-TRPML3 channel at pH 4.8

Chemicals

ChemComp-NAG:
N-ACETYL-D-GLUCOSAMINE

SourceHomo sapiens / human
KeywordsAnimals / Binding Sites / Cell Line / Cryoelectron Microscopy / Endosomes / HEK293 Cells / Humans / Ion Channel Gating / Lysosomes / MCOLN3 protein, human / Models, Molecular / Protein Domains / Protein Structure, Secondary / Sf9 Cells / Spodoptera / Transient Receptor Potential Channels / TRANSPORT PROTEIN / ion channel / TRP channel / lysosomal

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Feb 20, 2018. PDBj/BINDS workshop in Osaka University

PDBj/BINDS workshop in Osaka University

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    Oct 4, 2017. Three pioneers of this field were awarded Nobel Prize in Chemistry 2017

    Three pioneers of this field were awarded Nobel Prize in Chemistry 2017

    • Jacques Dubochet (University of Lausanne, Switzerland) is a pioneer of ice-embedding method of EM specimen (as known as cryo-EM), Most of 3DEM structures in EMDB and PDB are obtained using his method.
    • Joachim Frank (Columbia University, New York, USA) is a pioneer of single particle reconstruction, which is the most used reconstruction method for 3DEM structures in EMDB and EM entries in PDB. And also, he is a develper of Spider, which is one of the most famous software in this field, and is used for some EM Navigor data (e.g. map projection/slice images).
    • Richard Henderson (MRC Laboratory of Molecular Biology, Cambridge, UK) was determined the first biomolecule structure by EM. The first EM entry in PDB, PDB-1brd is determinedby him.

    External links: The 2017 Nobel Prize in Chemistry - Press Release

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    Jul 12, 2017. Major update of PDB

    Major update of PDB

    • wwPDB released updated PDB data conforming to the new PDBx/mmCIF dictionary. This is a major update changing the version number from 4 to 5, and with Remediation, in which all the entries are updated. See below links for details.
    • In this update, many items about electron microscopy experimental information are reorganized (e.g. em_software). Now, EM Navigator and Yorodumi are based on the updated data.

    External links: wwPDB Remediation / Enriched Model Files Conforming to OneDep Data Standards Now Available in the PDB FTP Archive

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    EMN Papers

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