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Showing 1 - 50 of 60 items for author: y. & j. & zhang

PDB-6b3q:
Cryo-EM structure of human insulin degrading enzyme in complex with insulin
Method: single particle / : Liang WG, Zhang Z, Bailey LJ, Kossiakoff AA, Tan YZ, Wei H, Carragher B, Potter SC, Tang WJ

PDB-6b7y:
Cryo-EM structure of human insulin degrading enzyme
Method: single particle / : Liang WG, Zhang Z, Bailey LJ, Kossiakoff AA, Tan YZ, Wei H, Carragher B, Potter SC, Tang WJ

PDB-5yhq:
Cryo-EM Structure of CVA6 VLP
Method: single particle / : Chen J, Zhang C, Huang Z, Cong Y

PDB-6b7n:
Cryo-electron microscopy structure of porcine delta coronavirus spike protein in the pre-fusion state
Method: single particle / : Shang J, Zheng Y, Yang Y, Liu C, Geng Q, Tai W, Du L, Zhou Y, Zhang W, Li F

PDB-5m50:
Mechanism of microtubule minus-end recognition and protection by CAMSAP proteins
Method: single particle / : Akhmanova A, Moores CA, Baldus M, Steinmetz MO, Topf M, Roberts AJ, Grant BJ, Scarabelli G, Joseph AP, van Hooff JJE, Houben K, Hua S, Luo Y, Stangier MM, Jiang K, Atherton J

PDB-5m54:
Mechanism of microtubule minus-end recognition and protection by CAMSAP proteins
Method: single particle / : Akhmanova A, Moores CA, Baldus M, Steinmetz MO, Topf M, Roberts AJ, Grant BJ, Scarabelli G, Joseph AJ, van Hooff JJE, Houben K, Hua S, Luo Y, Stangier MM, Jiang K, Atherton J

PDB-5m5c:
Mechanism of microtubule minus-end recognition and protection by CAMSAP proteins
Method: single particle / : Akhmanova A, Moores CA, Baldus M, Steinmetz MO, Topf M, Roberts AJ, Grant BJ, Scarabelli G, Joseph AP, van Hooff JJE, Houben K, Hua S, Luo Y, Stangier MM, Jiang K, Atherton J

PDB-5v7q:
Cryo-EM structure of the large ribosomal subunit from Mycobacterium tuberculosis bound with a potent linezolid analog
Method: single particle / : Yang K, Chang JY, Cui Z, Zhang J

PDB-5v93:
Cryo-EM structure of the 70S ribosome from Mycobacterium tuberculosis bound with Capreomycin
Method: single particle / : Yang K, Chang JY, Cui Z, Li X, Meng R, Duan L, Thongchol J, Jakana J, Huwe C, Sacchettini J, Zhang J

PDB-5xwy:
Electron cryo-microscopy structure of LbuCas13a-crRNA binary complex
Method: single particle / : Zhang X, Wang Y, Ma J, Liu L, Li X, Li Z, You L, Wang J, Wang M

PDB-5xjc:
Cryo-EM structure of the human spliceosome just prior to exon ligation at 3.6 angstrom
Method: single particle / : Zhang X, Yan C, Hang J, Finci IL, Lei J, Shi Y

PDB-5vai:
Cryo-EM structure of the activated Glucagon-like peptide-1 receptor in complex with G protein
Method: single particle / : Zhang Y, Sun B, Feng D, Hu H, Chu M, Qu Q, Tarrasch JT, Li S, Kobilka TS, Kobilka BK, Skiniotis G

PDB-5uz7:
Volta phase plate cryo-electron microscopy structure of a calcitonin receptor-heterotrimeric Gs protein complex
Method: single particle / : Liang YL, Khoshouei M, Radjainia M, Zhang Y, Glukhova A, Tarrasch J, Thal DM, Furness SGB, Christopoulos G, Coudrat T, Danev R, Baumeister W, Miller LJ, Christopoulos A, Kobilka BK, Wootten D, Skiniotis G, Sexton PM

PDB-5x58:
Prefusion structure of SARS-CoV spike glycoprotein, conformation 1
Method: single particle / : Yuan Y, Cao D, Zhang Y, Ma J, Qi J, Wang Q, Lu G, Wu Y, Yan J, Shi Y, Zhang X, Gao GF

PDB-5x59:
Prefusion structure of MERS-CoV spike glycoprotein, three-fold symmetry
Method: single particle / : Yuan Y, Cao D, Zhang Y, Ma J, Qi J, Wang Q, Lu G, Wu Y, Yan J, Shi Y, Zhang X, Gao GF

PDB-5x5b:
Prefusion structure of SARS-CoV spike glycoprotein, conformation 2
Method: single particle / : Yuan Y, Cao D, Zhang Y, Ma J, Qi J, Wang Q, Lu G, Wu Y, Yan J, Shi Y, Zhang X, Gao GF

PDB-5x5c:
Prefusion structure of MERS-CoV spike glycoprotein, conformation 1
Method: single particle / : Yuan Y, Cao D, Zhang Y, Ma J, Qi J, Wang Q, Lu G, Wu Y, Yan J, Shi Y, Zhang X, Gao GF

PDB-5x5f:
Prefusion structure of MERS-CoV spike glycoprotein, conformation 2
Method: single particle / : Yuan Y, Cao D, Zhang Y, Ma J, Qi J, Wang Q, Lu G, Wu Y, Yan J, Shi Y, Zhang X, Gao GF

PDB-5u0p:
Cryo-EM structure of the transcriptional Mediator
Method: single particle / : Tsai KL, Yu X, Gopalan S, Chao TC, Zhang Y, Florens L, Washburn MP, Murakami K, Conaway RC, Conaway JW, Asturias F

PDB-5u0s:
Cryo-EM structure of the Mediator-RNAPII complex
Method: single particle / : Tsai KL, Yu X, Gopalan S, Chao TC, Zhang Y, Florens L, Washburn MP, Murakami K, Conaway RC, Conaway JW, Asturias F

PDB-5wte:
Cryo-EM structure for Hepatitis A virus full particle
Method: single particle / : Wang X, Zhu L, Dang M, Hu Z, Gao Q, Yuan S, Sun Y, Zhang B, Ren J, Walter TS, Wang J, Fry EE, Stuart DI, Rao Z

PDB-5wtf:
Cryo-EM structure for Hepatitis A virus empty particle
Method: single particle / : Wang X, Zhu L, Dang M, Hu Z, Gao Q, Yuan S, Sun Y, Zhang B, Ren J, Walter TS, Wang J, Fry EE, Stuart DI, Rao Z

PDB-5wth:
Cryo-EM structure for Hepatitis A virus complexed with FAB
Method: single particle / : Wang X, Zhu L, Dang M, Hu Z, Gao Q, Yuan S, Sun Y, Zhang B, Ren J, Walter TS, Wang J, Fry EE, Stuart DI, Rao Z

PDB-5h37:
Cryo-EM structure of zika virus complexed with Fab C10 at pH 8.0
Method: single particle / : Zhang S, Kostyuchenko V, Ng TS, Lim XN, Ooi JSG, Lambert S, Tan TY, Widman D, Shi J, Baric RS, Lok SM

PDB-3jbm:
Electron cryo-microscopy of a virus-like particle of orange-spotted grouper nervous necrosis virus
Method: single particle / : Xie J, Li K, Gao Y, Huang R, Lai Y, Shi Y, Yang S, Zhu G, Zhang Q, He J

PDB-5gqh:
Cryo-EM structure of PaeCas3-AcrF3 complex
Method: single particle / : Zhang X, Ma J, Wang Y, Wang J

PDB-3jb8:
Insight into Three-dimensional structure of Maize Chlorotic Mottle Virus Revealed by Single Particle Analysis
Method: single particle / : Wang CY, Zhang QF, Gao YZ, Zhou XP, Ji G, Huang XJ, Hong J, Zhang CX

PDB-3jct:
Cryo-em structure of eukaryotic pre-60S ribosomal subunits
Method: single particle / : Wu S, Kumcuoglu B, Yan KG, Brown H, Zhang YX, Tan D, Gamalinda M, Yuan Y, Li ZF, Jakovljevic J, Ma CY, Lei JL, Dong MQ, Woolford Jr JL, Gao N

PDB-3jau:
The cryoEM map of EV71 mature viron in complex with the Fab fragment of antibody D5
Method: single particle / : Fan C, Ye XH, Ku ZQ, Zuo T, Kong LL, Zhang C, Shi JP, Liu QW, Chen T, Zhang YY, Jiang W, Zhang LQ, Huang Z, Cong Y

PDB-3jcd:
Structure of Escherichia coli EF4 in posttranslocational ribosomes (Post EF4)
Method: single particle / : Zhang D, Yan K, Liu G, Song G, Luo J, Shi Y, Cheng E, Wu S, Jiang T, Low J, Gao N, Qin Y

PDB-3jce:
Structure of Escherichia coli EF4 in pretranslocational ribosomes (Pre EF4)
Method: single particle / : Zhang D, Yan K, Liu G, Song G, Luo J, Shi Y, Cheng E, Wu S, Jiang T, Low J, Gao N, Qin Y

PDB-3jbl:
Cryo-EM Structure of the Activated NAIP2/NLRC4 Inflammasome Reveals Nucleated Polymerization
Method: single particle / : Zhang L, Chen S, Ruan J, Wu J, Tong AB, Yin Q, Li Y, David L, Lu A, Wang WL, Marks C, Ouyang Q, Zhang X, Mao Y, Wu H

PDB-5ady:
Cryo-EM structures of the 50S ribosome subunit bound with HflX
Method: single particle / : Zhang Y, Mandava CS, Cao W, Li X, Zhang D, Li N, Zhang Y, Zhang X, Qin Y, Mi K, Lei J, Sanyal S, Gao N

PDB-3ja8:
Cryo-EM structure of the MCM2-7 double hexamer
Method: single particle / : Li N, Zhai Y, Zhang Y, Li W, Yang M, Lei J, Tye BK, Gao N

PDB-3j8h:
Structure of the rabbit ryanodine receptor RyR1 in complex with FKBP12 at 3.8 Angstrom resolution
Method: single particle / : Yan Z, Bai X, Yan C, Wu J, Scheres SHW, Shi Y, Yan N

PDB-3j8g:
Electron cryo-microscopy structure of EngA bound with the 50S ribosomal subunit
Method: single particle / : Zhang X, Yan K, Zhang Y, Li N, Ma C, Li Z, Zhang Y, Feng B, Liu J, Sun Y, Xu Y, Lei J, Gao N

PDB-3j7v:
Capsid Expansion Mechanism Of Bacteriophage T7 Revealed By Multi-State Atomic Models Derived From Cryo-EM Reconstructions
Method: single particle / : Guo F, Liu Z, Fang PA, Zhang Q, Wright ET, Wu W, Zhang C, Vago F, Ren Y, Jakata J, Chiu W, Serwer P, Jiang W

PDB-3j7w:
Capsid Expansion Mechanism Of Bacteriophage T7 Revealed By Multi-State Atomic Models Derived From Cryo-EM Reconstructions
Method: single particle / : Guo F, Liu Z, Fang PA, Zhang Q, Wright ET, Wu W, Zhang C, Vago F, Ren Y, Jakata J, Chiu W, Serwer P, Jiang W

PDB-3j7x:
Capsid Expansion Mechanism Of Bacteriophage T7 Revealed By Multi-State Atomic Models Derived From Cryo-EM Reconstructions
Method: single particle / : Guo F, Liu Z, Fang PA, Zhang Q, Wright ET, Wu W, Zhang C, Vago F, Ren Y, Jakata J, Chiu W, Serwer P, Jiang W

PDB-4ckg:
Helical reconstruction of ACAP1(BAR-PH domain) decorated membrane tubules by cryo-electron microscopy
Method: helical / : Pang XY, Fan J, Zhang Y, Zhang K, Gao BQ, Ma J, Li J, Deng YC, Zhou QJ, Hsu V, Sun F

PDB-4ckh:
Helical reconstruction of ACAP1(BAR-PH domain) decorated membrane tubules by cryo-electron microscopy
Method: helical / : Pang XY, Fan J, Zhang Y, Zhang K, Gao BQ, Ma J, Li J, Deng YC, Zhou QJ, Hsu V, Sun F

PDB-4v8m:
High-resolution cryo-electron microscopy structure of the Trypanosoma brucei ribosome
Method: single particle / : Hashem Y, des Georges A, Fu J, Buss SN, Jossinet F, Jobe A, Zhang Q, Liao HY, Grassucci RA, Bajaj C, Westhof E, Madison-Antenucci S, Frank J

PDB-4csu:
Cryo-EM structures of the 50S ribosome subunit bound with ObgE
Method: single particle / : Feng B, Mandava CS, Guo Q, Wang J, Cao W, Li N, Zhang Y, Zhang Y, Wang Z, Wu J, Sanyal S, Lei J, Gao N

PDB-3zee:
Electron cyro-microscopy helical reconstruction of Par-3 N terminal domain
Method: helical / : Zhang Y, Wang W, Chen J, Zhang K, Gao F, Gong W, Zhang M, Sun F, Feng W

PDB-3j1b:
Cryo-EM structure of 8-fold symmetric rATcpn-alpha in apo state
Method: single particle / : Zhang K, Wang L, Liu YX, Wang X, Gao B, Hu ZJ, Ji G, Chan KY, Schulten K, Dong ZY, Sun F

PDB-3j1c:
Cryo-EM structure of 9-fold symmetric rATcpn-alpha in apo state
Method: single particle / : Zhang K, Wang L, Liu YX, Wang X, Gao B, Hu ZJ, Ji G, Chan KY, Schulten K, Dong ZY, Sun F

PDB-3j1e:
Cryo-EM structure of 9-fold symmetric rATcpn-beta in apo state
Method: single particle / : Zhang K, Wang L, Liu YX, Wang X, Gao B, Hu ZJ, Ji G, Chan KY, Schulten K, Dong ZY, Sun F

PDB-3j1f:
Cryo-EM structure of 9-fold symmetric rATcpn-beta in ATP-binding state
Method: single particle / : Zhang K, Wang L, Liu YX, Wang X, Gao B, Hu ZJ, Ji G, Chan KY, Schulten K, Dong ZY, Sun F

PDB-3j3v:
Atomic model of the immature 50S subunit from Bacillus subtilis (state I-a)
Method: single particle / : Li N, Guo Q, Zhang Y, Yuan Y, Ma C, Lei J, Gao N

PDB-3j3w:
Atomic model of the immature 50S subunit from Bacillus subtilis (state II-a)
Method: single particle / : Li N, Guo Q, Zhang Y, Yuan Y, Ma C, Lei J, Gao N

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Oct 4, 2017. Three pioneers of this field were awarded Nobel Prize in Chemistry 2017

Three pioneers of this field were awarded Nobel Prize in Chemistry 2017

  • Jacques Dubochet (University of Lausanne, Switzerland) is a pioneer of ice-embedding method of EM specimen (as known as cryo-EM), Most of 3DEM structures in EMDB and PDB are obtained using his method.
  • Joachim Frank (Columbia University, New York, USA) is a pioneer of single particle reconstruction, which is the most used reconstruction method for 3DEM structures in EMDB and EM entries in PDB. And also, he is a develper of Spider, which is one of the most famous software in this field, and is used for some EM Navigor data (e.g. map projection/slice images).
  • Richard Henderson (MRC Laboratory of Molecular Biology, Cambridge, UK) was determined the first biomolecule structure by EM. The first EM entry in PDB, PDB-1brd is determinedby him.

External links: The 2017 Nobel Prize in Chemistry - Press Release

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