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Showing 1 - 50 of 68 items for author: f. & yan

PDB-6b7n:
Cryo-electron microscopy structure of porcine delta coronavirus spike protein in the pre-fusion state
Method: single particle / : Shang J, Zheng Y, Yang Y, Liu C, Geng Q, Tai W, Du L, Zhou Y, Zhang W, Li F

PDB-5w3s:
Cryo-electron microscopy structure of a TRPML3 ion channel
Method: single particle / : Hirschi M, Herzik MA, Wie J, Suo Y, Borschel WF, Ren D, Lander GC, Lee SY

PDB-5xs4:
Structure of Coxsackievirus A6 (CVA6) virus A-particle
Method: single particle / : Zheng QB, He MZ, Xu LF, Yu H, Li SW, Cheng T

PDB-5xs5:
Structure of Coxsackievirus A6 (CVA6) virus procapsid particle
Method: single particle / : Zheng QB, He MZ, Xu LF, Yu H, Cheng T, Li SW

PDB-5xs7:
Structure of Coxsackievirus A6 (CVA6) virus A-particle in complex with the neutralizing antibody fragment 1D5
Method: single particle / : Zheng QB, He MZ, Xu LF, Yu H, Li SW, Cheng T

PDB-5xmi:
Cryo-EM Structure of the ATP-bound VPS4 mutant-E233Q hexamer (masked)
Method: single particle / : Sun S, Li L, Yang F, Wang X, Fan F, Li X, Wang H, Sui S

PDB-5xmk:
Cryo-EM structure of the ATP-bound Vps4 mutant-E233Q complex with Vta1 (masked)
Method: single particle / : Sun S, Li L, Yang F, Wang X, Fan F, Li X, Wang H, Sui S

PDB-5uzb:
Cryo-EM structure of the MAL TIR domain filament
Method: helical / : Ve T, Vajjhala PR, Hedger A, Croll T, DiMaio F, Horsefield S, Yu X, Lavrencic P, Hassan Z, Morgan GP, Mansell A, Mobli M, O'Carrol A, Chauvin B, Gambin Y, Sierecki E, Landsberg MJ, Stacey KJ, Egelman EH, Kobe B

PDB-5x58:
Prefusion structure of SARS-CoV spike glycoprotein, conformation 1
Method: single particle / : Yuan Y, Cao D, Zhang Y, Ma J, Qi J, Wang Q, Lu G, Wu Y, Yan J, Shi Y, Zhang X, Gao GF

PDB-5x59:
Prefusion structure of MERS-CoV spike glycoprotein, three-fold symmetry
Method: single particle / : Yuan Y, Cao D, Zhang Y, Ma J, Qi J, Wang Q, Lu G, Wu Y, Yan J, Shi Y, Zhang X, Gao GF

PDB-5x5b:
Prefusion structure of SARS-CoV spike glycoprotein, conformation 2
Method: single particle / : Yuan Y, Cao D, Zhang Y, Ma J, Qi J, Wang Q, Lu G, Wu Y, Yan J, Shi Y, Zhang X, Gao GF

PDB-5x5c:
Prefusion structure of MERS-CoV spike glycoprotein, conformation 1
Method: single particle / : Yuan Y, Cao D, Zhang Y, Ma J, Qi J, Wang Q, Lu G, Wu Y, Yan J, Shi Y, Zhang X, Gao GF

PDB-5x5f:
Prefusion structure of MERS-CoV spike glycoprotein, conformation 2
Method: single particle / : Yuan Y, Cao D, Zhang Y, Ma J, Qi J, Wang Q, Lu G, Wu Y, Yan J, Shi Y, Zhang X, Gao GF

PDB-5uz9:
Cryo EM structure of anti-CRISPRs, AcrF1 and AcrF2, bound to type I-F crRNA-guided CRISPR surveillance complex
Method: single particle / : Chowdhury S, Carter J, Rollins MF, Jackson RN, Hoffmann C, Nosaka L, Bondy-Denomy J, Maxwell KL, Davidson AR, Fischer ER, Lander GC, Wiedenheft B

PDB-5ln3:
The human 26S Proteasome at 6.8 Ang.
Method: single particle / : Schweitzer A, Beck F, Sakata E, Unverdorben P

PDB-5u4i:
Structural Basis of Co-translational Quality Control by ArfA and RF2 Bound to Ribosome
Method: single particle / : Zeng F, Chen Y, Remis J, Shekhar M, Phillips JC, Tajkhorshid E, Jin H

PDB-5u4j:
Structural Basis of Co-translational Quality Control by ArfA and RF2 Bound to Ribosome
Method: single particle / : Zeng F, Chen Y, Remis J, Shekhar M, Phillips JC, Tajkhorshid E, Jin H

PDB-5j8v:
Structure of rabbit ryanodine receptor RyR1 open state activated by calcium ion
Method: single particle / : Wang X, Wei R, Yin C, Sun F

PDB-3jb8:
Insight into Three-dimensional structure of Maize Chlorotic Mottle Virus Revealed by Single Particle Analysis
Method: single particle / : Wang CY, Zhang QF, Gao YZ, Zhou XP, Ji G, Huang XJ, Hong J, Zhang CX

PDB-3jco:
Structure of yeast 26S proteasome in M1 state derived from Titan dataset
Method: single particle / : Luan B, Huang XL, Wu JP, Shi YG, Wang F

PDB-3jcp:
Structure of yeast 26S proteasome in M2 state derived from Titan dataset
Method: single particle / : Luan B, Huang XL, Wu JP, Shi YG, Wang F

PDB-5jnx:
The 6.6 A cryo-EM structure of the full-length human NPC1 in complex with the cleaved glycoprotein of Ebola virus
Method: single particle / : Gong X, Qian HW, Zhou XH, Wu JP, Wan T, Shi Y, Gao F, Zhou Q, Yan N

PDB-3jct:
Cryo-em structure of eukaryotic pre-60S ribosomal subunits
Method: single particle / : Wu S, Kumcuoglu B, Yan KG, Brown H, Zhang YX, Tan D, Gamalinda M, Yuan Y, Li ZF, Jakovljevic J, Ma CY, Lei JL, Dong MQ, Woolford Jr JL, Gao N

PDB-5fna:
Cryo-EM reconstruction of caspase-1 CARD
Method: helical / : Li Y, Lu A, Schmidt FI, Yin Q, Chen S, Fu TM, Tong AB, Ploegh HL, Mao Y, Wu H

PDB-5fmw:
The poly-C9 component of the Complement Membrane Attack Complex
Method: single particle / : Dudkina NV, Spicer BA, Reboul CF, Conroy PJ, Lukoyanova N, Elmlund H, Law RHP, Ekkel SM, Kondos SC, Goode RJA, Ramm G, Whisstock JC, Saibil HR, Dunstone MA

PDB-3jbu:
Mechanisms of Ribosome Stalling by SecM at Multiple Elongation Steps
Method: single particle / : Zhang J, Pan XJ, Yan KG, Sun S, Gao N, Sui SF

PDB-3jbv:
Mechanisms of Ribosome Stalling by SecM at Multiple Elongation Steps
Method: single particle / : Zhang J, Pan XJ, Yan KG, Sun S, Gao N, Sui SF

PDB-3jbq:
Domain Organization and Conformational Plasticity of the G Protein Effector, PDE6
Method: single particle / : Zhang Z, He F, Constantine R, Baker ML, Baehr W, Schmid MF, Wensel TG, Agosto MA

PDB-5ac9:
Structure-based energetics of protein interfaces guide Foot-and-Mouth disease virus vaccine design
Method: single particle / : Kotecha A, Seago J, Scott K, Burman A, Loureiro S, Ren J, Porta C, Ginn HM, Jackson T, PerezMartin E, Siebert CA, Paul G, Huiskonen JT, Jones IM, Esnouf RM, Fry EE, Maree FF, Charleston B, Stuart DI

PDB-5aca:
Structure-based energetics of protein interfaces guide Foot-and-Mouth disease virus vaccine design
Method: single particle / : Kotecha A, Seago J, Scott K, Burman A, Loureiro S, Ren J, Porta C, Ginn HM, Jackson T, Perez-Martin E, Siebert CA, Paul G, Huiskonen JT, Jones IM, Esnouf RM, Fry EE, Maree FF, Charleston B, Stuart DI

PDB-3jab:
Domain organization and conformational plasticity of the G protein effector, PDE6
Method: single particle / : Zhang Z, He F, Constantine R, Baker ML, Baehr W, Schmid MF, Wensel TG, Agosto MA

PDB-3j9b:
Electron cryo-microscopy of an RNA polymerase
Method: single particle / : Chang SH, Sun DP, Liang HH, Wang J, Li J, Guo L, Wang XL, Guan CC, Boruah BM, Yuan LM, Feng F, Yang MR, Wojdyla J, Wang JW, Wang MT, Wang HW, Liu YF

PDB-4v2t:
Membrane embedded pleurotolysin pore with 13 fold symmetry
Method: single particle / : Lukoyanova N, Kondos SC, Farabella I, Law RHP, Reboul CF, Caradoc-Davies TT, Spicer BA, Kleifeld O, Perugini M, Ekkel S, Hatfaludi T, Oliver K, Hotze EM, Tweten RK, Whisstock JC, Topf M, Dunstone MA, Saibil HR

PDB-4v3a:
Membrane bound pleurotolysin prepore (TMH1 lock) trapped with engineered disulphide cross-link
Method: single particle / : Lukoyanova N, Kondos SC, Farabella I, Law RHP, Reboul CF, CaradocDavies TT, Spicer BA, Kleifeld O, Perugini M, Ekkel S, Hatfaludi T, Oliver K, Hotze EM, Tweten RK, Whisstock JC, Topf M, Dunstone MA, Saibil HR

PDB-4v3m:
Membrane bound pleurotolysin prepore (TMH2 helix lock) trapped with engineered disulphide cross-link
Method: single particle / : Lukoyanova N, Kondos SC, Farabella I, Law RHP, Reboul CF, Caradoc-Davies TT, Spicer BA, Kleifeld O, Perugini M, Ekkel S, Hatfaludi T, Oliver K, Hotze EM, Tweten RK, Whisstock JC, Topf M, Dunstone MA, Saibil HR

PDB-4v3n:
Membrane bound pleurotolysin prepore (TMH2 strand lock) trapped with engineered disulphide cross-link
Method: single particle / : Lukoyanova N, Kondos SC, Farabella I, Law RHP, Reboul CF, Caradoc-Davies TT, Spicer BA, Kleifeld O, Perugini M, Ekkel S, Hatfaludi T, Oliver K, Hotze EM, Tweten RK, Whisstock JC, Topf M, Dunstone MA, Saibil HR

PDB-4ckg:
Helical reconstruction of ACAP1(BAR-PH domain) decorated membrane tubules by cryo-electron microscopy
Method: helical / : Pang XY, Fan J, Zhang Y, Zhang K, Gao BQ, Ma J, Li J, Deng YC, Zhou QJ, Hsu V, Sun F

PDB-4ckh:
Helical reconstruction of ACAP1(BAR-PH domain) decorated membrane tubules by cryo-electron microscopy
Method: helical / : Pang XY, Fan J, Zhang Y, Zhang K, Gao BQ, Ma J, Li J, Deng YC, Zhou QJ, Hsu V, Sun F

PDB-3j6q:
Identification of the active sites in the methyltransferases of a transcribing dsRNA virus
Method: single particle / : Zhu B, Yang C, Liu H, Cheng L, Song F, Zeng S, Huang X, Ji G, Zhu P

PDB-4cxg:
Regulation of the mammalian elongation cycle by 40S subunit rolling: a eukaryotic-specific ribosome rearrangement
Method: single particle / : Budkevich TV, Giesebrecht J, Behrmann E, Loerke J, Ramrath DJF, Mielke T, Ismer J, Hildebrand P, Tung CS, Nierhaus KH, Sanbonmatsu KY, Spahn CMT

PDB-4cxh:
Regulation of the mammalian elongation cycle by 40S subunit rolling: a eukaryotic-specific ribosome rearrangement
Method: single particle / : Budkevich TV, Giesebrecht J, Behrmann E, Loerke J, Ramrath DJF, Mielke T, Ismer J, Hildebrand P, Tung CS, Nierhaus KH, Sanbonmatsu KY, Spahn CMT

PDB-4uje:
Regulation of the mammalian elongation cycle by 40S subunit rolling: a eukaryotic-specific ribosome rearrangement
Method: single particle / : Budkevich TV, Giesebrecht J, Behrmann E, Loerke J, Ramrath DJF, Mielke T, Ismer J, Hildebrand P, Tung CS, Nierhaus KH, Sanbonmatsu KY, Spahn CMT

PDB-3zif:
Cryo-EM structures of two intermediates provide insight into adenovirus assembly and disassembly
Method: single particle / : Cheng L, Huang X, Li X, Xiong W, Sun W, Yang C, Zhang K, Wang Y, Liu H, Ji G, Sun F, Zheng C, Zhu P

PDB-3zee:
Electron cyro-microscopy helical reconstruction of Par-3 N terminal domain
Method: helical / : Zhang Y, Wang W, Chen J, Zhang K, Gao F, Gong W, Zhang M, Sun F, Feng W

PDB-3j1b:
Cryo-EM structure of 8-fold symmetric rATcpn-alpha in apo state
Method: single particle / : Zhang K, Wang L, Liu YX, Wang X, Gao B, Hu ZJ, Ji G, Chan KY, Schulten K, Dong ZY, Sun F

PDB-3j1c:
Cryo-EM structure of 9-fold symmetric rATcpn-alpha in apo state
Method: single particle / : Zhang K, Wang L, Liu YX, Wang X, Gao B, Hu ZJ, Ji G, Chan KY, Schulten K, Dong ZY, Sun F

PDB-3j1e:
Cryo-EM structure of 9-fold symmetric rATcpn-beta in apo state
Method: single particle / : Zhang K, Wang L, Liu YX, Wang X, Gao B, Hu ZJ, Ji G, Chan KY, Schulten K, Dong ZY, Sun F

PDB-3j1f:
Cryo-EM structure of 9-fold symmetric rATcpn-beta in ATP-binding state
Method: single particle / : Zhang K, Wang L, Liu YX, Wang X, Gao B, Hu ZJ, Ji G, Chan KY, Schulten K, Dong ZY, Sun F

PDB-3j3r:
Structural dynamics of the MecA-ClpC complex revealed by cryo-EM
Method: single particle / : Liu J, Mei Z, Li N, Qi Y, Xu Y, Shi Y, Wang F, Lei J, Gao N

PDB-3j3s:
Structural dynamics of the MecA-ClpC complex revealed by cryo-EM
Method: single particle / : Liu J, Mei Z, Li N, Qi Y, Xu Y, Shi Y, Wang F, Lei J, Gao N

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Oct 4, 2017. Three pioneers of this field were awarded Nobel Prize in Chemistry 2017

Three pioneers of this field were awarded Nobel Prize in Chemistry 2017

  • Jacques Dubochet (University of Lausanne, Switzerland) is a pioneer of ice-embedding method of EM specimen (as known as cryo-EM), Most of 3DEM structures in EMDB and PDB are obtained using his method.
  • Joachim Frank (Columbia University, New York, USA) is a pioneer of single particle reconstruction, which is the most used reconstruction method for 3DEM structures in EMDB and EM entries in PDB. And also, he is a develper of Spider, which is one of the most famous software in this field, and is used for some EM Navigor data (e.g. map projection/slice images).
  • Richard Henderson (MRC Laboratory of Molecular Biology, Cambridge, UK) was determined the first biomolecule structure by EM. The first EM entry in PDB, PDB-1brd is determinedby him.

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