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Cryo-EM structure of human respiratory complex I

by single particle reconstruction, at 3.7 A resolution

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#1: Deposited structure unit, Imaged by Jmol

#2: Superimposition on EM map, EMDB-6773, Imaged by UCSF CHIMERA

Entry
Summary
Database / IDPORTEIN DATA BANK (PDB) / 5xtd
TitleCryo-EM structure of human respiratory complex I
DescriptorAcyl carrier protein,mitochondrial
NADH-ubiquinone oxidoreductase 75 kDa subunit,mitochondrial
(NADH dehydrogenase [ubiquinone] flavoprotein ...) x 3
(NADH dehydrogenase [ubiquinone] iron-sulfur protein ...) x 7
(NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit ...) x 12
and more 3 items
KeywordsOXIDOREDUCTASE/ELECTRON TRANSPORT, Homo sapiens, Oxidoreductase, Respiratory, OXIDOREDUCTASE-ELECTRON TRANSPORT complex
AuthorsGu, J., Wu, M., Yang, M.
DateDeposition: 2017-06-19, Release: 2017-08-30
PDBj Mine pagesSummary, Structural Details, Experimental Details, Functional Details
Other databasesRCSB-PDB, PDBe, FSSP, SCOP
Structure Visualization
MoviesMovie Page

#1: Deposited structure unit, Imaged by Jmol

#2: Superimposition on EM map, EMDB-6773, Imaged by UCSF CHIMERA

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Article
Citation - primary
ArticleCell, Vol. 170, Issue 6, Page 1247-1257.e12, Year 2017
TitleArchitecture of Human Mitochondrial Respiratory Megacomplex I2III2IV2.
AuthorsRunyu Guo, Shuai Zong, Meng Wu, Jinke Gu, Maojun Yang
Ministry of Education Key Laboratory of Protein Science, Tsinghua-Peking Joint Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, 100084 Beijing, China.
KeywordsCryoelectron Microscopy, Electron Transport Chain Complex Proteins (chemistry), Electron Transport Complex I (chemistry, 1.6.5.3), Electron Transport Complex II (chemistry, 1.3.5.1), Humans, Mitochondria (chemistry), Models, Molecular, Multienzyme Complexes (chemistry), respiratory complex II (1.6.5.3)
LinksPubMed: 28844695, PII: S0092-8674(17)30887-5, DOI: 10.1016/j.cell.2017.07.050
Components
ID 1 : Complex I-51kD,CI-51kD,NADH dehydrogenase flavoprotein 1,NADH-ubiquinone oxidoreductase 51 kDa subunit
DescriptionNADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
Typepolypeptide(L)
Formula weight47323.938 Da
Number of molecules1
ID1
Ec1.6.5.3,1.6.99.3
SourceMethod: Isolated from a natural source
Src id: 1
Common name: Human
Alt source flag: sample
Beg seq num: 1
End seq num: 431
NCBI taxonomy: ID:9606
Organism scientific: Homo sapiens
LinksUniProt: P49821, Sequence view
ID 2 : Complex I-23kD,CI-23kD,NADH-ubiquinone oxidoreductase 23 kDa subunit,TYKY subunit
DescriptionNADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
Typepolypeptide(L)
Formula weight20314.037 Da
Number of molecules1
ID2
Ec1.6.5.3,1.6.99.3
SourceMethod: Isolated from a natural source
Src id: 1
Common name: Human
Alt source flag: sample
Beg seq num: 1
End seq num: 176
NCBI taxonomy: ID:9606
Organism scientific: Homo sapiens
LinksUniProt: O00217, Sequence view
ID 3 : Complex I-20kD,CI-20kD,NADH-ubiquinone oxidoreductase 20 kDa subunit,PSST subunit
DescriptionNADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
Typepolypeptide(L)
Formula weight17887.928 Da
Number of molecules1
ID3
Ec1.6.5.3,1.6.99.3
SourceMethod: Isolated from a natural source
Src id: 1
Common name: Human
Alt source flag: sample
Beg seq num: 1
End seq num: 156
NCBI taxonomy: ID:9606
Organism scientific: Homo sapiens
LinksUniProt: O75251, Sequence view
ID 4 : Complex I-B14,CI-B14,LYR motif-containing protein 6,NADH-ubiquinone oxidoreductase B14 subunit
DescriptionNADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6
Typepolypeptide(L)
Formula weight13758.070 Da
Number of molecules1
ID4
SourceMethod: Isolated from a natural source
Src id: 1
Common name: Human
Alt source flag: sample
Beg seq num: 1
End seq num: 113
NCBI taxonomy: ID:9606
Organism scientific: Homo sapiens
LinksUniProt: P56556, Sequence view
ID 5 : Complex I-B8,CI-B8,NADH-ubiquinone oxidoreductase B8 subunit
DescriptionNADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2
Typepolypeptide(L)
Formula weight9535.905 Da
Number of molecules1
ID5
SourceMethod: Isolated from a natural source
Src id: 1
Common name: Human
Alt source flag: sample
Beg seq num: 1
End seq num: 83
NCBI taxonomy: ID:9606
Organism scientific: Homo sapiens
LinksUniProt: O43678, Sequence view
ID 6 : ACP,CI-SDAP,NADH-ubiquinone oxidoreductase 9.6 kDa subunit
DescriptionAcyl carrier protein, mitochondrial
Typepolypeptide(L)
Formula weight9845.247 Da
Number of molecules2
ID6
SourceMethod: Isolated from a natural source
Src id: 1
Common name: Human
Alt source flag: sample
Beg seq num: 1
End seq num: 85
NCBI taxonomy: ID:9606
Organism scientific: Homo sapiens
LinksUniProt: O14561, Sequence view
ID 7 : Complex I subunit B13,Complex I-13kD-B,CI-13kD-B,NADH-ubiquinone oxidoreductase 13 kDa-B subunit
DescriptionNADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
Typepolypeptide(L)
Formula weight13119.208 Da
Number of molecules1
ID7
SourceMethod: Isolated from a natural source
Src id: 1
Common name: Human
Alt source flag: sample
Beg seq num: 1
End seq num: 112
NCBI taxonomy: ID:9606
Organism scientific: Homo sapiens
LinksUniProt: Q16718, Sequence view
ID 8 : Complex I-B14.5a,CI-B14.5a,NADH-ubiquinone oxidoreductase subunit B14.5a
DescriptionNADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7
Typepolypeptide(L)
Formula weight12282.051 Da
Number of molecules1
ID8
SourceMethod: Isolated from a natural source
Src id: 1
Common name: Human
Alt source flag: sample
Beg seq num: 1
End seq num: 110
NCBI taxonomy: ID:9606
Organism scientific: Homo sapiens
LinksUniProt: O95182, Sequence view
ID 9 : Complex I-39kD,CI-39kD,NADH-ubiquinone oxidoreductase 39 kDa subunit
DescriptionNADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial
Typepolypeptide(L)
Formula weight38387.594 Da
Number of molecules1
ID9
SourceMethod: Isolated from a natural source
Src id: 1
Common name: Human
Alt source flag: sample
Beg seq num: 1
End seq num: 337
NCBI taxonomy: ID:9606
Organism scientific: Homo sapiens
LinksUniProt: Q16795, Sequence view
ID 10 : Complex I-9kD,CI-9kD,NADH-ubiquinone oxidoreductase 9 kDa subunit,Renal carcinoma antigen NY-REN-4
DescriptionNADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
Typepolypeptide(L)
Formula weight3900.312 Da
Number of molecules1
ID10
SourceMethod: Isolated from a natural source
Src id: 1
Common name: Human
Alt source flag: sample
Beg seq num: 1
End seq num: 33
NCBI taxonomy: ID:9606
Organism scientific: Homo sapiens
LinksUniProt: P56181, Sequence view
ID 11 : Complex I-18 kDa,CI-18 kDa,Complex I-AQDQ,CI-AQDQ,NADH-ubiquinone oxidoreductase 18 kDa subunit
DescriptionNADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
Typepolypeptide(L)
Formula weight13721.598 Da
Number of molecules1
ID11
SourceMethod: Isolated from a natural source
Src id: 1
Common name: Human
Alt source flag: sample
Beg seq num: 1
End seq num: 118
NCBI taxonomy: ID:9606
Organism scientific: Homo sapiens
LinksUniProt: O43181, Sequence view
ID 12 : Complex I-75kD,CI-75kD
DescriptionNADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Typepolypeptide(L)
Formula weight75471.484 Da
Number of molecules1
ID12
Ec1.6.5.3,1.6.99.3
SourceMethod: Isolated from a natural source
Src id: 1
Common name: Human
Alt source flag: sample
Beg seq num: 1
End seq num: 687
NCBI taxonomy: ID:9606
Organism scientific: Homo sapiens
LinksUniProt: P28331, Sequence view
ID 13 : 13 kDa differentiation-associated protein,Complex I-B17.2,CIB17.2,NADH-ubiquinone oxidoreductase subunit B17.2
DescriptionNADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12
Typepolypeptide(L)
Formula weight16880.068 Da
Number of molecules1
ID13
SourceMethod: Isolated from a natural source
Src id: 1
Common name: Human
Alt source flag: sample
Beg seq num: 1
End seq num: 143
NCBI taxonomy: ID:9606
Organism scientific: Homo sapiens
LinksUniProt: Q9UI09, Sequence view
ID 14 : NADH-ubiquinone oxidoreductase 24 kDa subunit
DescriptionNADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
Typepolypeptide(L)
Formula weight23430.881 Da
Number of molecules1
ID14
Ec1.6.5.3,1.6.99.3
SourceMethod: Isolated from a natural source
Src id: 1
Common name: Human
Alt source flag: sample
Beg seq num: 1
End seq num: 212
NCBI taxonomy: ID:9606
Organism scientific: Homo sapiens
LinksUniProt: P19404, Sequence view
ID 15 : Complex I-30kD,CI-30kD,NADH-ubiquinone oxidoreductase 30 kDa subunit
DescriptionNADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
Typepolypeptide(L)
Formula weight24432.656 Da
Number of molecules1
ID15
Ec1.6.5.3,1.6.99.3
SourceMethod: Isolated from a natural source
Src id: 1
Common name: Human
Alt source flag: sample
Beg seq num: 1
End seq num: 208
NCBI taxonomy: ID:9606
Organism scientific: Homo sapiens
LinksUniProt: O75489, Sequence view
ID 16 : Complex I-49kD,CI-49kD,NADH-ubiquinone oxidoreductase 49 kDa subunit
DescriptionNADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
Typepolypeptide(L)
Formula weight49236.480 Da
Number of molecules1
ID16
Ec1.6.5.3,1.6.99.3
SourceMethod: Isolated from a natural source
Src id: 1
Common name: Human
Alt source flag: sample
Beg seq num: 1
End seq num: 430
NCBI taxonomy: ID:9606
Organism scientific: Homo sapiens
LinksUniProt: O75306, Sequence view
ID 17 : Complex I-MWFE,CI-MWFE,NADH-ubiquinone oxidoreductase MWFE subunit
DescriptionNADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1
Typepolypeptide(L)
Formula weight8084.391 Da
Number of molecules1
ID17
SourceMethod: Isolated from a natural source
Src id: 1
Common name: Human
Alt source flag: sample
Beg seq num: 1
End seq num: 70
NCBI taxonomy: ID:9606
Organism scientific: Homo sapiens
LinksUniProt: O15239, Sequence view
ID 18 : Complex I-13kD-A,CI-13kD-A,NADH-ubiquinone oxidoreductase 13 kDa-A subunit
DescriptionNADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
Typepolypeptide(L)
Formula weight10578.848 Da
Number of molecules1
ID18
SourceMethod: Isolated from a natural source
Src id: 1
Common name: Human
Alt source flag: sample
Beg seq num: 1
End seq num: 95
NCBI taxonomy: ID:9606
Organism scientific: Homo sapiens
LinksUniProt: O75380, Sequence view
ID 19 : Complex I-B9,CI-B9,NADH-ubiquinone oxidoreductase B9 subunit
DescriptionNADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3
Typepolypeptide(L)
Formula weight9156.602 Da
Number of molecules1
ID19
SourceMethod: Isolated from a natural source
Src id: 1
Common name: Human
Alt source flag: sample
Beg seq num: 1
End seq num: 83
NCBI taxonomy: ID:9606
Organism scientific: Homo sapiens
LinksUniProt: O95167, Sequence view
ID 20 : Complex I-B14.7,CI-B14.7,NADH-ubiquinone oxidoreductase subunit B14.7
DescriptionNADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11
Typepolypeptide(L)
Formula weight14736.853 Da
Number of molecules1
ID20
SourceMethod: Isolated from a natural source
Src id: 1
Common name: Human
Alt source flag: sample
Beg seq num: 1
End seq num: 140
NCBI taxonomy: ID:9606
Organism scientific: Homo sapiens
LinksUniProt: Q86Y39, Sequence view
ID 21 : Cell death regulatory protein GRIM-19,Complex I-B16.6,CI-B16.6,Gene associated with retinoic and interferon-induced mortality 19 protein,Gene associated with retinoic and IFN-induced mortality 19 protein,NADH-ubiquinone oxidoreductase B16.6 subunit
DescriptionNADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
Typepolypeptide(L)
Formula weight16132.570 Da
Number of molecules1
ID21
SourceMethod: Isolated from a natural source
Src id: 1
Common name: Human
Alt source flag: sample
Beg seq num: 1
End seq num: 138
NCBI taxonomy: ID:9606
Organism scientific: Homo sapiens
LinksUniProt: Q9P0J0, Sequence view
ID 22 : Complex I-AGGG,CI-AGGG,NADH-ubiquinone oxidoreductase AGGG subunit
DescriptionNADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial
Typepolypeptide(L)
Formula weight7468.270 Da
Number of molecules1
ID22
SourceMethod: Isolated from a natural source
Src id: 1
Common name: Human
Alt source flag: sample
Beg seq num: 1
End seq num: 59
NCBI taxonomy: ID:9606
Organism scientific: Homo sapiens
LinksUniProt: O95178, Sequence view
ID 23 : Complex I-B12,CI-B12,NADH-ubiquinone oxidoreductase B12 subunit
DescriptionNADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3
Typepolypeptide(L)
Formula weight9261.605 Da
Number of molecules1
ID23
SourceMethod: Isolated from a natural source
Src id: 1
Common name: Human
Alt source flag: sample
Beg seq num: 1
End seq num: 80
NCBI taxonomy: ID:9606
Organism scientific: Homo sapiens
LinksUniProt: O43676, Sequence view
ID 24 : Complex I-SGDH,CI-SGDH,NADH-ubiquinone oxidoreductase SGDH subunit
DescriptionNADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial
Typepolypeptide(L)
Formula weight16573.160 Da
Number of molecules1
ID24
SourceMethod: Isolated from a natural source
Src id: 1
Common name: Human
Alt source flag: sample
Beg seq num: 1
End seq num: 138
NCBI taxonomy: ID:9606
Organism scientific: Homo sapiens
LinksUniProt: O43674, Sequence view
ID 25 : Complex I-B17,CI-B17,NADH-ubiquinone oxidoreductase B17 subunit
DescriptionNADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6
Typepolypeptide(L)
Formula weight15517.228 Da
Number of molecules1
ID25
SourceMethod: Isolated from a natural source
Src id: 1
Common name: Human
Alt source flag: sample
Beg seq num: 1
End seq num: 128
NCBI taxonomy: ID:9606
Organism scientific: Homo sapiens
LinksUniProt: O95139, Sequence view
ID 26 : Complex I-ASHI,CI-ASHI,NADH-ubiquinone oxidoreductase ASHI subunit
DescriptionNADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial
Typepolypeptide(L)
Formula weight18267.562 Da
Number of molecules1
ID26
SourceMethod: Isolated from a natural source
Src id: 1
Common name: Human
Alt source flag: sample
Beg seq num: 1
End seq num: 153
NCBI taxonomy: ID:9606
Organism scientific: Homo sapiens
LinksUniProt: O95169, Sequence view
ID 27 : Complex I-PDSW,CI-PDSW,NADH-ubiquinone oxidoreductase PDSW subunit
DescriptionNADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10
Typepolypeptide(L)
Formula weight20721.650 Da
Number of molecules1
ID27
SourceMethod: Isolated from a natural source
Src id: 1
Common name: Human
Alt source flag: sample
Beg seq num: 1
End seq num: 171
NCBI taxonomy: ID:9606
Organism scientific: Homo sapiens
LinksUniProt: O96000, Sequence view
ID 28 : Complex I-ESSS,CI-ESSS,NADH-ubiquinone oxidoreductase ESSS subunit,Neuronal protein 17.3,p17.3
DescriptionNADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial
Typepolypeptide(L)
Formula weight11494.942 Da
Number of molecules1
ID28
SourceMethod: Isolated from a natural source
Src id: 1
Common name: Human
Alt source flag: sample
Beg seq num: 1
End seq num: 97
NCBI taxonomy: ID:9606
Organism scientific: Homo sapiens
LinksUniProt: Q9NX14, Sequence view
ID 29 : Complex I-KFYI,CI-KFYI,NADH-ubiquinone oxidoreductase KFYI subunit
DescriptionNADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial
Typepolypeptide(L)
Formula weight5704.602 Da
Number of molecules1
ID29
SourceMethod: Isolated from a natural source
Src id: 1
Common name: Human
Alt source flag: sample
Beg seq num: 1
End seq num: 47
NCBI taxonomy: ID:9606
Organism scientific: Homo sapiens
LinksUniProt: O43677, Sequence view
ID 30 : Complex I-B14.5b,CI-B14.5b,Human lung cancer oncogene 1 protein,HLC-1,NADH-ubiquinone oxidoreductase subunit B14.5b
DescriptionNADH dehydrogenase [ubiquinone] 1 subunit C2
Typepolypeptide(L)
Formula weight14209.521 Da
Number of molecules1
ID30
SourceMethod: Isolated from a natural source
Src id: 1
Common name: Human
Alt source flag: sample
Beg seq num: 1
End seq num: 119
NCBI taxonomy: ID:9606
Organism scientific: Homo sapiens
LinksUniProt: O95298, Sequence view
ID 31 : Complex I-15 kDa,CI-15 kDa,NADH-ubiquinone oxidoreductase 15 kDa subunit
DescriptionNADH dehydrogenase [ubiquinone] iron-sulfur protein 5
Typepolypeptide(L)
Formula weight12314.254 Da
Number of molecules1
ID31
SourceMethod: Isolated from a natural source
Src id: 1
Common name: Human
Alt source flag: sample
Beg seq num: 1
End seq num: 104
NCBI taxonomy: ID:9606
Organism scientific: Homo sapiens
LinksUniProt: O43920, Sequence view
ID 32 : NADH-ubiquinone oxidoreductase chain 2
DescriptionNADH-ubiquinone oxidoreductase chain 2
Typepolypeptide(L)
Formula weight39007.656 Da
Number of molecules1
ID32
Ec1.6.5.3
SourceMethod: Isolated from a natural source
Src id: 1
Common name: Human
Alt source flag: sample
Beg seq num: 1
End seq num: 347
NCBI taxonomy: ID:9606
Organism scientific: Homo sapiens
LinksUniProt: Q4GRX1, Sequence view
ID 33 : NADH-ubiquinone oxidoreductase chain 3
DescriptionNADH-ubiquinone oxidoreductase chain 3
Typepolypeptide(L)
Formula weight13147.871 Da
Number of molecules1
ID33
Ec1.6.5.3
SourceMethod: Isolated from a natural source
Src id: 1
Common name: Human
Alt source flag: sample
Beg seq num: 1
End seq num: 115
NCBI taxonomy: ID:9606
Organism scientific: Homo sapiens
LinksUniProt: B9EE38, Sequence view
ID 34 : NADH-ubiquinone oxidoreductase chain 4L
DescriptionNADH-ubiquinone oxidoreductase chain 4L
Typepolypeptide(L)
Formula weight10702.086 Da
Number of molecules1
ID34
Ec1.6.5.3
SourceMethod: Isolated from a natural source
Src id: 1
Common name: Human
Alt source flag: sample
Beg seq num: 1
End seq num: 97
NCBI taxonomy: ID:9606
Organism scientific: Homo sapiens
LinksUniProt: V9JN72, Sequence view
ID 35 : NADH-ubiquinone oxidoreductase chain 5
DescriptionNADH-ubiquinone oxidoreductase chain 5
Typepolypeptide(L)
Formula weight67096.023 Da
Number of molecules1
ID35
Ec1.6.5.3
SourceMethod: Isolated from a natural source
Src id: 1
Common name: Human
Alt source flag: sample
Beg seq num: 1
End seq num: 603
NCBI taxonomy: ID:9606
Organism scientific: Homo sapiens
LinksUniProt: X5BVZ3, Sequence view
ID 36 : NADH-ubiquinone oxidoreductase chain 6
DescriptionNADH-ubiquinone oxidoreductase chain 6
Typepolypeptide(L)
Formula weight18660.979 Da
Number of molecules1
ID36
Ec1.6.5.3
SourceMethod: Isolated from a natural source
Src id: 1
Common name: Human
Alt source flag: sample
Beg seq num: 1
End seq num: 174
NCBI taxonomy: ID:9606
Organism scientific: Homo sapiens
LinksUniProt: Q8HAX7, Sequence view
ID 37 : Complex I-MNLL,CI-MNLL,NADH-ubiquinone oxidoreductase MNLL subunit
DescriptionNADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1
Typepolypeptide(L)
Formula weight6741.883 Da
Number of molecules1
ID37
SourceMethod: Isolated from a natural source
Src id: 1
Common name: Human
Alt source flag: sample
Beg seq num: 1
End seq num: 56
NCBI taxonomy: ID:9606
Organism scientific: Homo sapiens
LinksUniProt: O75438, Sequence view
ID 38 : Complex I-B15,CI-B15,NADH-ubiquinone oxidoreductase B15 subunit
DescriptionNADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4
Typepolypeptide(L)
Formula weight15100.399 Da
Number of molecules1
ID38
SourceMethod: Isolated from a natural source
Src id: 1
Common name: Human
Alt source flag: sample
Beg seq num: 1
End seq num: 128
NCBI taxonomy: ID:9606
Organism scientific: Homo sapiens
LinksUniProt: O95168, Sequence view
ID 39 : Complex I-B22,CI-B22,LYR motif-containing protein 3,NADH-ubiquinone oxidoreductase B22 subunit
DescriptionNADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9
Typepolypeptide(L)
Formula weight21189.141 Da
Number of molecules1
ID39
SourceMethod: Isolated from a natural source
Src id: 1
Common name: Human
Alt source flag: sample
Beg seq num: 1
End seq num: 172
NCBI taxonomy: ID:9606
Organism scientific: Homo sapiens
LinksUniProt: Q9Y6M9, Sequence view
ID 40 : NADH-ubiquinone oxidoreductase chain 4
DescriptionNADH-ubiquinone oxidoreductase chain 4
Typepolypeptide(L)
Formula weight51689.688 Da
Number of molecules1
ID40
Ec1.6.5.3
SourceMethod: Isolated from a natural source
Src id: 1
Common name: Human
Alt source flag: sample
Beg seq num: 1
End seq num: 459
NCBI taxonomy: ID:9606
Organism scientific: Homo sapiens
LinksUniProt: B2XJG5, Sequence view
ID 41 : NADH-ubiquinone oxidoreductase chain 1
DescriptionNADH-ubiquinone oxidoreductase chain 1
Typepolypeptide(L)
Formula weight35621.215 Da
Number of molecules1
ID41
Ec1.6.5.3
SourceMethod: Isolated from a natural source
Src id: 1
Common name: Human
Alt source flag: sample
Beg seq num: 1
End seq num: 318
NCBI taxonomy: ID:9606
Organism scientific: Homo sapiens
LinksUniProt: H9PGF0, Sequence view
ID 42 : Complex I-19kD,CI-19kD,Complex I-PGIV,CI-PGIV,NADH-ubiquinone oxidoreductase 19 kDa subunit
DescriptionNADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8
Typepolypeptide(L)
Formula weight19853.736 Da
Number of molecules1
ID42
SourceMethod: Isolated from a natural source
Src id: 1
Common name: Human
Alt source flag: sample
Beg seq num: 1
End seq num: 169
NCBI taxonomy: ID:9606
Organism scientific: Homo sapiens
LinksUniProt: P51970, Sequence view
ID 43 : Cell adhesion protein SQM1,Complex I-B18,CI-B18,NADH-ubiquinone oxidoreductase B18 subunit
DescriptionNADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7
Typepolypeptide(L)
Formula weight16435.045 Da
Number of molecules1
ID43
SourceMethod: Isolated from a natural source
Src id: 1
Common name: Human
Alt source flag: sample
Beg seq num: 1
End seq num: 137
NCBI taxonomy: ID:9606
Organism scientific: Homo sapiens
LinksUniProt: P17568, Sequence view
ID 44 : Complex I-42kD,CI-42kD,NADH-ubiquinone oxidoreductase 42 kDa subunit
DescriptionNADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
Typepolypeptide(L)
Formula weight37200.270 Da
Number of molecules1
ID44
SourceMethod: Isolated from a natural source
Src id: 1
Common name: Human
Alt source flag: sample
Beg seq num: 1
End seq num: 320
NCBI taxonomy: ID:9606
Organism scientific: Homo sapiens
LinksUniProt: O95299, Sequence view
ID 45 : IRON/SULFUR CLUSTER
DescriptionIRON/SULFUR CLUSTER
Typenon-polymer
Formula weight351.640 Da
Number of molecules6
ID45
SourceMethod: Obtained synthetically
ID 46 : FLAVIN MONONUCLEOTIDE
DescriptionFLAVIN MONONUCLEOTIDE
Typenon-polymer
Formula weight456.344 Da
Number of molecules1
ID46
SourceMethod: Obtained synthetically
ID 47 : (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL
Description(9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL
Typenon-polymer
Formula weight767.132 Da
Number of molecules9
ID47
SourceMethod: Obtained synthetically
ID 48 : S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate
DescriptionS-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate
Typenon-polymer
Formula weight540.651 Da
Number of molecules2
ID48
SourceMethod: Obtained synthetically
ID 49 : NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
DescriptionNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Typenon-polymer
Formula weight745.421 Da
Number of molecules1
ID49
SourceMethod: Obtained synthetically
ID 50 : FE2/S2 (INORGANIC) CLUSTER
DescriptionFE2/S2 (INORGANIC) CLUSTER
Typenon-polymer
Formula weight175.820 Da
Number of molecules2
ID50
SourceMethod: Obtained synthetically
ID 51 : CARDIOLIPIN
DescriptionCARDIOLIPIN
Typenon-polymer
Formula weight1464.043 Da
Number of molecules5
ID51
SourceMethod: Obtained synthetically
ID 52 : 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine
Description1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine
Typenon-polymer
Formula weight749.073 Da
Number of molecules4
ID52
SourceMethod: Obtained synthetically
Sample
Entity assembly
Entity id list1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44
NameHuman respiratory complex I
SourceNATURAL
TypeCOMPLEX
Buffer
Specimen id1
PH7.4
Experiment
Aggregation statePARTICLE
Reconstruction methodSINGLE PARTICLE
Vitrification
Specimen id1
Cryogen nameETHANE
Experiment
MethodELECTRON MICROSCOPY
Electron Microscopy
Imaging
MicroscopeModel: FEI TITAN KRIOS
Electron gun
Electron sourceFIELD EMISSION GUN
Accelerating voltage300 kV
Illumination modeOTHER
Lens
ModeBRIGHT FIELD
Processing
Single particle entity
Image processing id1
Point symmetryC1
3D reconstruction
Image processing id1
Number of particles167761
Resolution3.7 A
Resolution methodFSC 0.143 CUT-OFF
Symmetry typePOINT
Download
PDB format
Allpdb5xtd.ent.gz
pdb5xtd.ent (uncompressed file)
Header onlypdb5xtd.ent.gz
mmCIF format
mmCIF5xtd.cif.gz
XML format
All5xtd.xml.gz
No-atom5xtd-noatom.xml.gz
Ext-atom5xtd-extatom.xml.gz
Movie files
movie #1
.mp4 (H.264/MPEG-4 AVC format), 3.1 MB
.webm (WebM/VP8 format), 5.8 MB
movie #2
.mp4 (H.264/MPEG-4 AVC format), 3.8 MB
.webm (WebM/VP8 format), 6.7 MB