eF-site ID 9rsa-AB PDB Code 9rsa Chain A, B click to enlarge Title CRYSTAL STRUCTURE OF TWO COVALENT NUCLEOSIDE DERIVATIVES OF RIBONUCLEASE A Classification HYDROLASE (PHOSPHORIC DIESTER) Compound RIBONUCLEASE A Source Bos taurus (Bovine) (RNAS1_BOVIN) Sequence A:  KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRC KPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMS ITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHF DASV B:  KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRC KPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMS ITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHF DASV Description Functional site 1) chain A residue 12 type sequence H description ACTIVE SITE OF THE ENZYME IN CHAIN A source : AD1 2) chain A residue 41 type sequence K description ACTIVE SITE OF THE ENZYME IN CHAIN A source : AD1 3) chain A residue 43 type sequence V description ACTIVE SITE OF THE ENZYME IN CHAIN A source : AD1 4) chain A residue 44 type sequence N description ACTIVE SITE OF THE ENZYME IN CHAIN A source : AD1 5) chain A residue 45 type sequence T description ACTIVE SITE OF THE ENZYME IN CHAIN A source : AD1 6) chain A residue 119 type sequence H description ACTIVE SITE OF THE ENZYME IN CHAIN A source : AD1 7) chain A residue 120 type sequence F description ACTIVE SITE OF THE ENZYME IN CHAIN A source : AD1 8) chain A residue 121 type sequence D description ACTIVE SITE OF THE ENZYME IN CHAIN A source : AD1 9) chain A residue 123 type sequence S description ACTIVE SITE OF THE ENZYME IN CHAIN A source : AD1 10) chain B residue 12 type sequence H description ACTIVE SITE OF THE ENZYME IN CHAIN B source : AD2 11) chain B residue 41 type sequence K description ACTIVE SITE OF THE ENZYME IN CHAIN B source : AD2 12) chain B residue 43 type sequence V description ACTIVE SITE OF THE ENZYME IN CHAIN B source : AD2 13) chain B residue 44 type sequence N description ACTIVE SITE OF THE ENZYME IN CHAIN B source : AD2 14) chain B residue 45 type sequence T description ACTIVE SITE OF THE ENZYME IN CHAIN B source : AD2 15) chain B residue 119 type sequence H description ACTIVE SITE OF THE ENZYME IN CHAIN B source : AD2 16) chain B residue 120 type sequence F description ACTIVE SITE OF THE ENZYME IN CHAIN B source : AD2 17) chain B residue 121 type sequence D description ACTIVE SITE OF THE ENZYME IN CHAIN B source : AD2 18) chain B residue 123 type sequence S description ACTIVE SITE OF THE ENZYME IN CHAIN B source : AD2 19) chain A residue 118 type sequence V description BINDING SITE FOR RESIDUE ADU A 125 source : AC1 20) chain A residue 119 type sequence H description BINDING SITE FOR RESIDUE ADU A 125 source : AC1 21) chain B residue 118 type sequence V description BINDING SITE FOR RESIDUE ADU B 125 source : AC2 22) chain B residue 119 type sequence H description BINDING SITE FOR RESIDUE ADU B 125 source : AC2 23) chain A residue 12 type catalytic sequence H description 164 source MCSA : MCSA1 24) chain A residue 41 type catalytic sequence K description 164 source MCSA : MCSA1 25) chain A residue 119 type catalytic sequence H description 164 source MCSA : MCSA1 26) chain A residue 120 type catalytic sequence F description 164 source MCSA : MCSA1 27) chain A residue 121 type catalytic sequence D description 164 source MCSA : MCSA1 28) chain B residue 12 type catalytic sequence H description 164 source MCSA : MCSA2 29) chain B residue 41 type catalytic sequence K description 164 source MCSA : MCSA2 30) chain B residue 119 type catalytic sequence H description 164 source MCSA : MCSA2 31) chain B residue 120 type catalytic sequence F description 164 source MCSA : MCSA2 32) chain B residue 121 type catalytic sequence D description 164 source MCSA : MCSA2 33) chain A residue 40-46 type prosite sequence CKPVNTF description RNASE_PANCREATIC Pancreatic ribonuclease family signature. CKpvNTF source prosite : PS00127 34) chain A residue 12 type ACT_SITE sequence H description Proton acceptor source Swiss-Prot : SWS_FT_FI1 35) chain B residue 12 type ACT_SITE sequence H description Proton acceptor source Swiss-Prot : SWS_FT_FI1 36) chain A residue 119 type ACT_SITE sequence H description Proton donor source Swiss-Prot : SWS_FT_FI2 37) chain B residue 119 type ACT_SITE sequence H description Proton donor source Swiss-Prot : SWS_FT_FI2 38) chain A residue 7 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 39) chain B residue 85 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI3 40) chain A residue 10 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI3 41) chain A residue 41 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 42) chain A residue 66 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 43) chain A residue 85 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI3 44) chain B residue 7 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 45) chain B residue 10 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI3 46) chain B residue 41 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 47) chain B residue 66 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 48) chain A residue 1 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:4030761 source Swiss-Prot : SWS_FT_FI4 49) chain A residue 7 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:4030761 source Swiss-Prot : SWS_FT_FI4 50) chain A residue 37 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:4030761 source Swiss-Prot : SWS_FT_FI4 51) chain A residue 41 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:4030761 source Swiss-Prot : SWS_FT_FI4 52) chain B residue 1 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:4030761 source Swiss-Prot : SWS_FT_FI4 53) chain B residue 7 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:4030761 source Swiss-Prot : SWS_FT_FI4 54) chain B residue 37 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:4030761 source Swiss-Prot : SWS_FT_FI4 55) chain B residue 41 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:4030761 source Swiss-Prot : SWS_FT_FI4 56) chain A residue 34 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; partial => ECO:0000269|PubMed:19358553 source Swiss-Prot : SWS_FT_FI5 57) chain B residue 34 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; partial => ECO:0000269|PubMed:19358553 source Swiss-Prot : SWS_FT_FI5

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