eF-site ID 8hvp-B PDB Code 8hvp Chain B click to enlarge Title STRUCTURE AT 2.5-ANGSTROMS RESOLUTION OF CHEMICALLY SYNTHESIZED HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE COMPLEXED WITH A HYDROXYETHYLENE*-BASED INHIBITOR Classification HYDROLASE/HYDROLASE INHIBITOR Compound HIV-1 PROTEASE Source Human immunodeficiency virus type 1 group M subtype B (isolate ARV2/SF2) (HIV-1) (8HVP) Sequence B:  PQITLWQRPLVTIRIGGQLKEALLDTGADDTVLEEMNLPG KWKPKMIGGIGGFIKVRQYDQIPVEIXGHKAIGTVLVGPT PVNIIGRNLLTQIGXTLNF Description Functional site 1) chain B residue 25 type sequence D description source : DTB 2) chain B residue 26 type sequence T description source : DTB 3) chain B residue 27 type sequence G description source : DTB 4) chain B residue 8 type sequence R description BINDING SITE FOR CHAIN I OF INHIBITOR VAL-SER-GLN-ASN-LEU-PSI(CH(OH)-CH2)-VAL-ILE-VAL source : AC1 5) chain B residue 23 type sequence L description BINDING SITE FOR CHAIN I OF INHIBITOR VAL-SER-GLN-ASN-LEU-PSI(CH(OH)-CH2)-VAL-ILE-VAL source : AC1 6) chain B residue 25 type sequence D description BINDING SITE FOR CHAIN I OF INHIBITOR VAL-SER-GLN-ASN-LEU-PSI(CH(OH)-CH2)-VAL-ILE-VAL source : AC1 7) chain B residue 27 type sequence G description BINDING SITE FOR CHAIN I OF INHIBITOR VAL-SER-GLN-ASN-LEU-PSI(CH(OH)-CH2)-VAL-ILE-VAL source : AC1 8) chain B residue 28 type sequence A description BINDING SITE FOR CHAIN I OF INHIBITOR VAL-SER-GLN-ASN-LEU-PSI(CH(OH)-CH2)-VAL-ILE-VAL source : AC1 9) chain B residue 29 type sequence D description BINDING SITE FOR CHAIN I OF INHIBITOR VAL-SER-GLN-ASN-LEU-PSI(CH(OH)-CH2)-VAL-ILE-VAL source : AC1 10) chain B residue 30 type sequence D description BINDING SITE FOR CHAIN I OF INHIBITOR VAL-SER-GLN-ASN-LEU-PSI(CH(OH)-CH2)-VAL-ILE-VAL source : AC1 11) chain B residue 47 type sequence I description BINDING SITE FOR CHAIN I OF INHIBITOR VAL-SER-GLN-ASN-LEU-PSI(CH(OH)-CH2)-VAL-ILE-VAL source : AC1 12) chain B residue 48 type sequence G description BINDING SITE FOR CHAIN I OF INHIBITOR VAL-SER-GLN-ASN-LEU-PSI(CH(OH)-CH2)-VAL-ILE-VAL source : AC1 13) chain B residue 82 type sequence V description BINDING SITE FOR CHAIN I OF INHIBITOR VAL-SER-GLN-ASN-LEU-PSI(CH(OH)-CH2)-VAL-ILE-VAL source : AC1 14) chain B residue 84 type sequence I description BINDING SITE FOR CHAIN I OF INHIBITOR VAL-SER-GLN-ASN-LEU-PSI(CH(OH)-CH2)-VAL-ILE-VAL source : AC1 15) chain B residue 78 type SITE sequence G description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 16) chain B residue 78 type MOD_RES sequence G description Phosphotyrosine; by host => ECO:0000250 source Swiss-Prot : SWS_FT_FI2

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