eF-site/Summary 8at1-A

eF-site ID	8at1-A
PDB Code	8at1
Chain	A

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Title	CRYSTAL STRUCTURES OF ASPARTATE CARBAMOYLTRANSFERASE LIGATED WITH PHOSPHONOACETAMIDE, MALONATE, AND CTP OR ATP AT 2.8-ANGSTROMS RESOLUTION AND NEUTRAL P*H
Classification	TRANSFERASE (CARBAMOYL-P,ASPARTATE)
Compound	ASPARTATE CARBAMOYLTRANSFERASE (R STATE), CATALYTIC CHAIN
Source	Escherichia coli (strain K12) (PYRI_ECOLI)

Sequence	A:	ANPLYQKHIISINDLSRDDLNLVLATAAKLKANPQPELLK HKVIASCFFEASTRTRLSFQTSMHRLGASVVGFSDSANTS LGKKGETLADTISVISTYVDAIVMRHPQEGAARLATEFSG NVPVLNAGDGSNQHPTQTLLDLFTIQQTEGRLDNLHVAMV GDLKYGRTVHSLTQALAKFDGNRFYFIAPDALAMPEYILD MLDEKGIAWSLHSSIEEVMAEVDILYMTRVQKERLDPSEY ANVKAQFVLRASDLHNAKANMKVLHPLPRVDEIATDVDKT PHAWYFQQAGNGIFARQALLALVLNRDLVL

Description

Functional site


1)	chain	A
	residue	54
	type
	sequence	R
	description	BINDING SITES OF COMBINED PCT AND MAL MOLECULES. SITE ACTUALLY CONTAIN AN ADDITIONAL TWO RESIDUES OF SYMMETRY RELATED. THE OTHER RESIDUES, SER A 80, AND LYS A 84 ARE IN AN ADJACENT (THREE-FOLD RELATED) CATALYTIC CHAIN.
	source	: PMA

2)	chain	A
	residue	55
	type
	sequence	T
	description	BINDING SITES OF COMBINED PCT AND MAL MOLECULES. SITE ACTUALLY CONTAIN AN ADDITIONAL TWO RESIDUES OF SYMMETRY RELATED. THE OTHER RESIDUES, SER A 80, AND LYS A 84 ARE IN AN ADJACENT (THREE-FOLD RELATED) CATALYTIC CHAIN.
	source	: PMA

3)	chain	A
	residue	105
	type
	sequence	R
	description	BINDING SITES OF COMBINED PCT AND MAL MOLECULES. SITE ACTUALLY CONTAIN AN ADDITIONAL TWO RESIDUES OF SYMMETRY RELATED. THE OTHER RESIDUES, SER A 80, AND LYS A 84 ARE IN AN ADJACENT (THREE-FOLD RELATED) CATALYTIC CHAIN.
	source	: PMA

4)	chain	A
	residue	134
	type
	sequence	H
	description	BINDING SITES OF COMBINED PCT AND MAL MOLECULES. SITE ACTUALLY CONTAIN AN ADDITIONAL TWO RESIDUES OF SYMMETRY RELATED. THE OTHER RESIDUES, SER A 80, AND LYS A 84 ARE IN AN ADJACENT (THREE-FOLD RELATED) CATALYTIC CHAIN.
	source	: PMA

5)	chain	A
	residue	137
	type
	sequence	Q
	description	BINDING SITES OF COMBINED PCT AND MAL MOLECULES. SITE ACTUALLY CONTAIN AN ADDITIONAL TWO RESIDUES OF SYMMETRY RELATED. THE OTHER RESIDUES, SER A 80, AND LYS A 84 ARE IN AN ADJACENT (THREE-FOLD RELATED) CATALYTIC CHAIN.
	source	: PMA

6)	chain	A
	residue	167
	type
	sequence	R
	description	BINDING SITES OF COMBINED PCT AND MAL MOLECULES. SITE ACTUALLY CONTAIN AN ADDITIONAL TWO RESIDUES OF SYMMETRY RELATED. THE OTHER RESIDUES, SER A 80, AND LYS A 84 ARE IN AN ADJACENT (THREE-FOLD RELATED) CATALYTIC CHAIN.
	source	: PMA

7)	chain	A
	residue	229
	type
	sequence	R
	description	BINDING SITES OF COMBINED PCT AND MAL MOLECULES. SITE ACTUALLY CONTAIN AN ADDITIONAL TWO RESIDUES OF SYMMETRY RELATED. THE OTHER RESIDUES, SER A 80, AND LYS A 84 ARE IN AN ADJACENT (THREE-FOLD RELATED) CATALYTIC CHAIN.
	source	: PMA

8)	chain	A
	residue	231
	type
	sequence	Q
	description	BINDING SITES OF COMBINED PCT AND MAL MOLECULES. SITE ACTUALLY CONTAIN AN ADDITIONAL TWO RESIDUES OF SYMMETRY RELATED. THE OTHER RESIDUES, SER A 80, AND LYS A 84 ARE IN AN ADJACENT (THREE-FOLD RELATED) CATALYTIC CHAIN.
	source	: PMA

9)	chain	A
	residue	266
	type
	sequence	P
	description	BINDING SITES OF COMBINED PCT AND MAL MOLECULES. SITE ACTUALLY CONTAIN AN ADDITIONAL TWO RESIDUES OF SYMMETRY RELATED. THE OTHER RESIDUES, SER A 80, AND LYS A 84 ARE IN AN ADJACENT (THREE-FOLD RELATED) CATALYTIC CHAIN.
	source	: PMA

10)	chain	A
	residue	267
	type
	sequence	L
	description	BINDING SITES OF COMBINED PCT AND MAL MOLECULES. SITE ACTUALLY CONTAIN AN ADDITIONAL TWO RESIDUES OF SYMMETRY RELATED. THE OTHER RESIDUES, SER A 80, AND LYS A 84 ARE IN AN ADJACENT (THREE-FOLD RELATED) CATALYTIC CHAIN.
	source	: PMA

11)	chain	A
	residue	85
	type	BINDING
	sequence	G
	description	BINDING => ECO:0000255\|HAMAP-Rule:MF_00001, ECO:0000305\|PubMed:3380787
	source	Swiss-Prot : SWS_FT_FI2

12)	chain	A
	residue	168
	type	BINDING
	sequence	T
	description	BINDING => ECO:0000255\|HAMAP-Rule:MF_00001, ECO:0000305\|PubMed:3380787
	source	Swiss-Prot : SWS_FT_FI2

13)	chain	A
	residue	230
	type	BINDING
	sequence	V
	description	BINDING => ECO:0000255\|HAMAP-Rule:MF_00001, ECO:0000305\|PubMed:3380787
	source	Swiss-Prot : SWS_FT_FI2

14)	chain	A
	residue	48-55
	type	prosite
	sequence	FFEASTRT
	description	CARBAMOYLTRANSFERASE Aspartate and ornithine carbamoyltransferases signature. FfEaSTRT
	source	prosite : PS00097

15)	chain	A
	residue	55
	type	catalytic
	sequence	T
	description	405
	source	MCSA : MCSA1

16)	chain	A
	residue	56
	type	catalytic
	sequence	R
	description	405
	source	MCSA : MCSA1

17)	chain	A
	residue	85
	type	catalytic
	sequence	G
	description	405
	source	MCSA : MCSA1

18)	chain	A
	residue	106
	type	catalytic
	sequence	H
	description	405
	source	MCSA : MCSA1

19)	chain	A
	residue	135
	type	catalytic
	sequence	P
	description	405
	source	MCSA : MCSA1