eF-site ID 7kol-A PDB Code 7kol Chain A click to enlarge Title The crystal structure of Papain-Like Protease of SARS CoV-2 in complex with PLP_Snyder496 inhibitor Classification HYDROLASE/HYDROLASE inhibitor Compound Papain-like protease Source (R1A_SARS2) Sequence A:  VFTTVDNINLHTQVVDMSMTYGQQFGPTYLDGADVTKIKP HNSHEGKTFYVLPNDDTLRVEAFEYYHTTDPSFLGRYMSA LNHTKKWKYPQVNGLTSIKWADNNCYLATALLTLQQIELK FNPPALQDAYYRARAGEAANFCALILAYCNKTVGELGDVR ETMSYLFQHANLDSCKRVLNVVCKTCGQQQTTLKGVEAVM YMGTLSYEQFKKGVQIPCTCGKQATKYLVQQESPFVMMSA PPAQYELKHGTFTCASEYTGNYQCGHYKHITSKETLYCID GALLTKSSEYKGPITDVFYKENSYTTTI Description Functional site 1) chain A residue 189-226 type ZN_FING sequence CKTCGQQQTTLKGVEAVMYMGTLSYEQFKKGVQIPCTC description C4-type => ECO:0000255|PROSITE-ProRule:PRU00444 source Swiss-Prot : SWS_FT_FI1 2) chain A residue 189 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU00444 source Swiss-Prot : SWS_FT_FI4 3) chain A residue 192 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU00444 source Swiss-Prot : SWS_FT_FI4 4) chain A residue 224 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU00444 source Swiss-Prot : SWS_FT_FI4 5) chain A residue 226 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU00444 source Swiss-Prot : SWS_FT_FI4 6) chain A residue 111 type ACT_SITE sequence C description For PL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00444, ECO:0000269|PubMed:32726803 source Swiss-Prot : SWS_FT_FI2 7) chain A residue 272 type ACT_SITE sequence H description For PL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00444 source Swiss-Prot : SWS_FT_FI3 8) chain A residue 286 type ACT_SITE sequence D description For PL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00444 source Swiss-Prot : SWS_FT_FI3

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