eF-site ID 7kl9-A
PDB Code 7kl9
Chain A

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Title Structure of the SARS-CoV-2 S 6P trimer in complex with the ACE2 protein decoy, CTC-445.2 (State 4)
Classification ANTIVIRAL PROTEIN
Compound Spike glycoprotein
Source (7KL9)
Sequence A:  AYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFH
DNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLI
VNNATNVVIKVCEFQFCNDPFLGVEFRVYSSANNCTFEYV
SNLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPL
VDLPIGINITRFQTLLAAAYYVGYLQPRTFLLKYNENGTI
TDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTES
IVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADY
SVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGD
EVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKV
GGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEG
FNCYFPLQSYGFQPTNGVGYQPYRVVVLSFEAPATVCGPK
KSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRD
IADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQV
AVLYQDVNCTEVNVFQTRAGCLIGAEHVNNSYECDIPIGA
GICASYQTQSIIAYTMSLGAENSVAYSNNSIAIPTNFTIS
VTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCT
QLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFN
FSQILPDPSKPSKRSPIEDLLFNKVNGLTVLPPLLTDEMI
AQYTSALLAGTITSGWTFGAGPALQIPFPMQMAYRFNGIG
VTQNVLYENQKLIANQFNSAIGKIQDSLSSTPSALGKLQD
VVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDPPEAE
VQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMS
ECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPA
QEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFY
EPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPEL
Description (1)  Spike glycoprotein, CTC-445.2 inhibitor


Functional site

1) chain A
residue 603
type CARBOHYD
sequence N
description N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942
source Swiss-Prot : SWS_FT_FI10

2) chain A
residue 676
type CARBOHYD
sequence T
description O-linked (GlcNAc...) threonine; by host GALNT1 => ECO:0000269|PubMed:34732583
source Swiss-Prot : SWS_FT_FI11

3) chain A
residue 1134
type CARBOHYD
sequence N
description N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942
source Swiss-Prot : SWS_FT_FI12

4) chain A
residue 815
type SITE
sequence R
description Cleavage; by host TMPRSS2 or CTSL => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32703818, ECO:0000269|PubMed:34159616
source Swiss-Prot : SWS_FT_FI2

5) chain A
residue 61
type CARBOHYD
sequence N
description N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942
source Swiss-Prot : SWS_FT_FI4

6) chain A
residue 122
type CARBOHYD
sequence N
description N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942
source Swiss-Prot : SWS_FT_FI4

7) chain A
residue 717
type CARBOHYD
sequence N
description N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942
source Swiss-Prot : SWS_FT_FI4

8) chain A
residue 801
type CARBOHYD
sequence N
description N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942
source Swiss-Prot : SWS_FT_FI4

9) chain A
residue 1074
type CARBOHYD
sequence N
description N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942
source Swiss-Prot : SWS_FT_FI4

10) chain A
residue 165
type CARBOHYD
sequence N
description N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942
source Swiss-Prot : SWS_FT_FI6

11) chain A
residue 282
type CARBOHYD
sequence N
description N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942
source Swiss-Prot : SWS_FT_FI6

12) chain A
residue 331
type CARBOHYD
sequence N
description N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942
source Swiss-Prot : SWS_FT_FI6

13) chain A
residue 343
type CARBOHYD
sequence N
description N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942
source Swiss-Prot : SWS_FT_FI6

14) chain A
residue 616
type CARBOHYD
sequence N
description N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942
source Swiss-Prot : SWS_FT_FI6

15) chain A
residue 657
type CARBOHYD
sequence N
description N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942
source Swiss-Prot : SWS_FT_FI6

16) chain A
residue 1098
type CARBOHYD
sequence N
description N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942
source Swiss-Prot : SWS_FT_FI6

17) chain A
residue 234
type CARBOHYD
sequence N
description N-linked (GlcNAc...) (high mannose) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942
source Swiss-Prot : SWS_FT_FI7

18) chain A
residue 709
type CARBOHYD
sequence N
description N-linked (GlcNAc...) (high mannose) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942
source Swiss-Prot : SWS_FT_FI7

19) chain A
residue 323
type CARBOHYD
sequence T
description O-linked (GalNAc) threonine; by host => ECO:0000269|PubMed:32363391
source Swiss-Prot : SWS_FT_FI8

20) chain A
residue 325
type CARBOHYD
sequence S
description O-linked (HexNAc...) serine; by host => ECO:0000269|PubMed:32363391
source Swiss-Prot : SWS_FT_FI9


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