eF-site ID 7kj3-E PDB Code 7kj3 Chain E click to enlarge Title SARS-CoV-2 Spike Glycoprotein with two ACE2 Bound Classification VIRAL PROTEIN/HYDROLASE Compound Spike glycoprotein Source (ACE2_HUMAN) Sequence E:  IEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQ NMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQAL QQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQE CLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLY EEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRG QLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYISPIG CLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQ AWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQ KAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQ YDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKS IGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWR WMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCDP ASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLH KCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKNMN VRPLLNYFEPLFTWLKDQNKNSFVGWSTDWSPY Description (1)  Spike glycoprotein Functional site 1) chain E residue 103 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14754895 source Swiss-Prot : SWS_FT_FI8 2) chain E residue 432 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14754895 source Swiss-Prot : SWS_FT_FI8 3) chain E residue 546 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14754895, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19901337 source Swiss-Prot : SWS_FT_FI9 4) chain E residue 375 type ACT_SITE sequence E description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000305|PubMed:14754895, ECO:0000305|PubMed:27217402 source Swiss-Prot : SWS_FT_FI1 5) chain E residue 505 type ACT_SITE sequence H description Proton donor => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000305|PubMed:14754895 source Swiss-Prot : SWS_FT_FI2 6) chain E residue 169 type BINDING sequence R description BINDING => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000269|PubMed:14754895, ECO:0000305|PubMed:19021774 source Swiss-Prot : SWS_FT_FI3 7) chain E residue 477 type BINDING sequence W description BINDING => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000269|PubMed:14754895, ECO:0000305|PubMed:19021774 source Swiss-Prot : SWS_FT_FI3 8) chain E residue 481 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000269|PubMed:14754895, ECO:0000305|PubMed:19021774 source Swiss-Prot : SWS_FT_FI3 9) chain E residue 273 type BINDING sequence R description BINDING => ECO:0000305|PubMed:14754895 source Swiss-Prot : SWS_FT_FI4 10) chain E residue 345 type BINDING sequence H description BINDING => ECO:0000305|PubMed:14754895 source Swiss-Prot : SWS_FT_FI4 11) chain E residue 515 type BINDING sequence Y description BINDING => ECO:0000305|PubMed:14754895 source Swiss-Prot : SWS_FT_FI4 12) chain E residue 374 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000269|PubMed:14754895 source Swiss-Prot : SWS_FT_FI5 13) chain E residue 378 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000269|PubMed:14754895 source Swiss-Prot : SWS_FT_FI5 14) chain E residue 402 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000269|PubMed:14754895 source Swiss-Prot : SWS_FT_FI5 15) chain E residue 53 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000305|PubMed:14754895 source Swiss-Prot : SWS_FT_FI6 16) chain E residue 322 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000305|PubMed:14754895 source Swiss-Prot : SWS_FT_FI6 17) chain E residue 90 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14754895, ECO:0000269|PubMed:15084671, ECO:0000269|PubMed:19901337 source Swiss-Prot : SWS_FT_FI7

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