eF-site ID 7kj2-ABCD
PDB Code 7kj2
Chain A, B, C, D

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Title SARS-CoV-2 Spike Glycoprotein with one ACE2 Bound
Classification VIRAL PROTEIN/HYDROLASE
Compound Spike glycoprotein
Source (ACE2_HUMAN)
Sequence A:  AYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFH
AIHPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKSLLIV
NNATNVVIKVCEFQFCNDPFLGVCTFEYVSFKNLREFVFK
NIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINI
TRFQTLLAAYYVGYLQPRTFLLKYNENGTITDAVDCALDP
LSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNL
CPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFS
TFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQT
GKIADYNYKLPDDFTGCVIAWNSNNLDNYNYLYRLFRKSN
LKPFERDISTFPLQSYGFQPTNVGYQPYRVVVLSFELLHA
PATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFL
PFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITP
GTNTSNQVAVLYQDVNCTEVNVFQTRAGCLIGAEHVNNSY
ECDIPIGAGICASYQTQSIIAYTMSLGAENSVAYSNNSIA
IPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLL
LQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPP
IKDFGGFNFSQILPDPSKPSKRSFIEDLLFNKVTFNGLTV
LPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAM
QMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSS
TASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDI
LSRLDPPEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRA
SANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGV
VFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGT
HWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDP
LQPELDS
B:  AYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFH
NPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIV
NNATNVVIKVCEFQFCNDPFNNCTFEYVSFKNLREFVFKN
YFKIYSKHTPINDLPQGFSALEPLVDLPIGINITRFQTLL
AAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCT
LKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVF
NATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGV
SPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYN
YKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLK
PFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNG
VGYQPYRVVVLSFATVCGPKKSTNLVKNKCVNFNFNGLTG
TGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDIT
PCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVNVFQTRAG
CLIGAEHVNNSYECDIPIGAGICASYQTSQSIIAYTMSLG
AENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTM
YICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQE
VFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSFIED
LLFNKVTKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGW
TFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQ
FNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQL
SSNFGAISSVLNDILSRLDPPEAEVQIDRLITGRLQSLQT
YVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKG
YHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGK
AHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNC
DVVIGIVNNTVYDPLQPELDS
C:  AYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFH
NPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIV
NNATNVVIKVCEFQFCNDPFLGVNCTFEYVSFKNLREFVF
KNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGIN
ITRFQTLLAYYVGYLQPRTFLLKYNENGTITDAVDCALDP
LSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNL
CPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFS
TFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQT
GKIADYNYKLPDDFTGCVIAWNSNNLDSKNYNYLYRKPFE
RDISTPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVC
GPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQF
GRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTS
NQVAVLYQDVNCTEVNVFQTRAGCLIGAEHVNNSYECDIP
IGAGICASYQTQSIIAYTMSLGAENSVAYSNNSIAIPTNF
TISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGS
FCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFG
GFNFSQILPDPSKPSKRSFIEDLLFNKVTNGLTVLPPLLT
DEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRF
NGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALG
KLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDP
PEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAA
TKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVT
YVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQ
RNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELD
S
D:  IEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQ
NMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQAL
QQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQE
CLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLY
EEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRG
QLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYISPIG
CLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQ
AWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQ
KAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQ
YDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKS
IGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWR
WMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCDP
ASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLH
KCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKNMN
VRPLLNYFEPLFTWLKDQNKNSFVGWSTDWSPY
Description (1)  Spike glycoprotein


Functional site
1) chain D
residue 103
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14754895
source Swiss-Prot : SWS_FT_FI8
2) chain D
residue 432
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14754895
source Swiss-Prot : SWS_FT_FI8
3) chain C
residue 323
type CARBOHYD
sequence T
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14754895
source Swiss-Prot : SWS_FT_FI8
4) chain D
residue 546
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14754895, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19901337
source Swiss-Prot : SWS_FT_FI9
5) chain B
residue 325
type CARBOHYD
sequence S
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14754895, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19901337
source Swiss-Prot : SWS_FT_FI9
6) chain C
residue 325
type CARBOHYD
sequence S
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14754895, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19901337
source Swiss-Prot : SWS_FT_FI9
7) chain A
residue 603
type CARBOHYD
sequence N
description N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942
source Swiss-Prot : SWS_FT_FI10
8) chain B
residue 603
type CARBOHYD
sequence N
description N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942
source Swiss-Prot : SWS_FT_FI10
9) chain C
residue 603
type CARBOHYD
sequence N
description N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942
source Swiss-Prot : SWS_FT_FI10
10) chain A
residue 676
type CARBOHYD
sequence T
description O-linked (GlcNAc...) threonine; by host GALNT1 => ECO:0000269|PubMed:34732583
source Swiss-Prot : SWS_FT_FI11
11) chain B
residue 676
type CARBOHYD
sequence T
description O-linked (GlcNAc...) threonine; by host GALNT1 => ECO:0000269|PubMed:34732583
source Swiss-Prot : SWS_FT_FI11
12) chain C
residue 676
type CARBOHYD
sequence T
description O-linked (GlcNAc...) threonine; by host GALNT1 => ECO:0000269|PubMed:34732583
source Swiss-Prot : SWS_FT_FI11
13) chain D
residue 371-380
type prosite
sequence TAHHEMGHIQ
description ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TAHHEMGHIQ
source prosite : PS00142
14) chain A
residue 1134
type CARBOHYD
sequence N
description N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942
source Swiss-Prot : SWS_FT_FI12
15) chain B
residue 1134
type CARBOHYD
sequence N
description N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942
source Swiss-Prot : SWS_FT_FI12
16) chain C
residue 1134
type CARBOHYD
sequence N
description N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942
source Swiss-Prot : SWS_FT_FI12
17) chain D
residue 375
type ACT_SITE
sequence E
description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000305|PubMed:14754895, ECO:0000305|PubMed:27217402
source Swiss-Prot : SWS_FT_FI1
18) chain D
residue 505
type ACT_SITE
sequence H
description Proton donor => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000305|PubMed:14754895
source Swiss-Prot : SWS_FT_FI2
19) chain B
residue 815
type ACT_SITE
sequence R
description Proton donor => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000305|PubMed:14754895
source Swiss-Prot : SWS_FT_FI2
20) chain C
residue 815
type ACT_SITE
sequence R
description Proton donor => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000305|PubMed:14754895
source Swiss-Prot : SWS_FT_FI2
21) chain D
residue 169
type BINDING
sequence R
description BINDING => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000269|PubMed:14754895, ECO:0000305|PubMed:19021774
source Swiss-Prot : SWS_FT_FI3
22) chain D
residue 477
type BINDING
sequence W
description BINDING => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000269|PubMed:14754895, ECO:0000305|PubMed:19021774
source Swiss-Prot : SWS_FT_FI3
23) chain D
residue 481
type BINDING
sequence K
description BINDING => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000269|PubMed:14754895, ECO:0000305|PubMed:19021774
source Swiss-Prot : SWS_FT_FI3
24) chain D
residue 273
type BINDING
sequence R
description BINDING => ECO:0000305|PubMed:14754895
source Swiss-Prot : SWS_FT_FI4
25) chain D
residue 345
type BINDING
sequence H
description BINDING => ECO:0000305|PubMed:14754895
source Swiss-Prot : SWS_FT_FI4
26) chain D
residue 515
type BINDING
sequence Y
description BINDING => ECO:0000305|PubMed:14754895
source Swiss-Prot : SWS_FT_FI4
27) chain A
residue 801
type BINDING
sequence N
description BINDING => ECO:0000305|PubMed:14754895
source Swiss-Prot : SWS_FT_FI4
28) chain A
residue 1074
type BINDING
sequence N
description BINDING => ECO:0000305|PubMed:14754895
source Swiss-Prot : SWS_FT_FI4
29) chain B
residue 61
type BINDING
sequence N
description BINDING => ECO:0000305|PubMed:14754895
source Swiss-Prot : SWS_FT_FI4
30) chain B
residue 122
type BINDING
sequence N
description BINDING => ECO:0000305|PubMed:14754895
source Swiss-Prot : SWS_FT_FI4
31) chain B
residue 717
type BINDING
sequence N
description BINDING => ECO:0000305|PubMed:14754895
source Swiss-Prot : SWS_FT_FI4
32) chain B
residue 801
type BINDING
sequence N
description BINDING => ECO:0000305|PubMed:14754895
source Swiss-Prot : SWS_FT_FI4
33) chain B
residue 1074
type BINDING
sequence N
description BINDING => ECO:0000305|PubMed:14754895
source Swiss-Prot : SWS_FT_FI4
34) chain C
residue 61
type BINDING
sequence N
description BINDING => ECO:0000305|PubMed:14754895
source Swiss-Prot : SWS_FT_FI4
35) chain C
residue 122
type BINDING
sequence N
description BINDING => ECO:0000305|PubMed:14754895
source Swiss-Prot : SWS_FT_FI4
36) chain C
residue 717
type BINDING
sequence N
description BINDING => ECO:0000305|PubMed:14754895
source Swiss-Prot : SWS_FT_FI4
37) chain C
residue 801
type BINDING
sequence N
description BINDING => ECO:0000305|PubMed:14754895
source Swiss-Prot : SWS_FT_FI4
38) chain C
residue 1074
type BINDING
sequence N
description BINDING => ECO:0000305|PubMed:14754895
source Swiss-Prot : SWS_FT_FI4
39) chain D
residue 402
type BINDING
sequence E
description BINDING => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000269|PubMed:14754895
source Swiss-Prot : SWS_FT_FI5
40) chain D
residue 374
type BINDING
sequence H
description BINDING => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000269|PubMed:14754895
source Swiss-Prot : SWS_FT_FI5
41) chain D
residue 378
type BINDING
sequence H
description BINDING => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000269|PubMed:14754895
source Swiss-Prot : SWS_FT_FI5
42) chain A
residue 1098
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000305|PubMed:14754895
source Swiss-Prot : SWS_FT_FI6
43) chain B
residue 165
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000305|PubMed:14754895
source Swiss-Prot : SWS_FT_FI6
44) chain B
residue 282
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000305|PubMed:14754895
source Swiss-Prot : SWS_FT_FI6
45) chain B
residue 331
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000305|PubMed:14754895
source Swiss-Prot : SWS_FT_FI6
46) chain B
residue 343
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000305|PubMed:14754895
source Swiss-Prot : SWS_FT_FI6
47) chain B
residue 616
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000305|PubMed:14754895
source Swiss-Prot : SWS_FT_FI6
48) chain B
residue 657
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000305|PubMed:14754895
source Swiss-Prot : SWS_FT_FI6
49) chain B
residue 1098
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000305|PubMed:14754895
source Swiss-Prot : SWS_FT_FI6
50) chain C
residue 165
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000305|PubMed:14754895
source Swiss-Prot : SWS_FT_FI6
51) chain C
residue 282
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000305|PubMed:14754895
source Swiss-Prot : SWS_FT_FI6
52) chain C
residue 331
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000305|PubMed:14754895
source Swiss-Prot : SWS_FT_FI6
53) chain C
residue 343
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000305|PubMed:14754895
source Swiss-Prot : SWS_FT_FI6
54) chain C
residue 616
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000305|PubMed:14754895
source Swiss-Prot : SWS_FT_FI6
55) chain C
residue 657
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000305|PubMed:14754895
source Swiss-Prot : SWS_FT_FI6
56) chain C
residue 1098
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000305|PubMed:14754895
source Swiss-Prot : SWS_FT_FI6
57) chain D
residue 53
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000305|PubMed:14754895
source Swiss-Prot : SWS_FT_FI6
58) chain D
residue 322
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000305|PubMed:14754895
source Swiss-Prot : SWS_FT_FI6
59) chain A
residue 331
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000305|PubMed:14754895
source Swiss-Prot : SWS_FT_FI6
60) chain A
residue 343
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000305|PubMed:14754895
source Swiss-Prot : SWS_FT_FI6
61) chain A
residue 616
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000305|PubMed:14754895
source Swiss-Prot : SWS_FT_FI6
62) chain A
residue 657
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000305|PubMed:14754895
source Swiss-Prot : SWS_FT_FI6
63) chain B
residue 709
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14754895, ECO:0000269|PubMed:15084671, ECO:0000269|PubMed:19901337
source Swiss-Prot : SWS_FT_FI7
64) chain C
residue 234
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14754895, ECO:0000269|PubMed:15084671, ECO:0000269|PubMed:19901337
source Swiss-Prot : SWS_FT_FI7
65) chain C
residue 709
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14754895, ECO:0000269|PubMed:15084671, ECO:0000269|PubMed:19901337
source Swiss-Prot : SWS_FT_FI7
66) chain D
residue 90
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14754895, ECO:0000269|PubMed:15084671, ECO:0000269|PubMed:19901337
source Swiss-Prot : SWS_FT_FI7
67) chain A
residue 709
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14754895, ECO:0000269|PubMed:15084671, ECO:0000269|PubMed:19901337
source Swiss-Prot : SWS_FT_FI7
68) chain B
residue 234
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14754895, ECO:0000269|PubMed:15084671, ECO:0000269|PubMed:19901337
source Swiss-Prot : SWS_FT_FI7

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