eF-site ID 7ins-ABCDEFG PDB Code 7ins Chain A, B, C, D, E, F, G click to enlarge Title STRUCTURE OF PORCINE INSULIN COCRYSTALLIZED WITH CLUPEINE Z Classification HORMONE Compound INSULIN (CHAIN A) Source Sus scrofa (Pig) (7INS) Sequence A:  GIVEQCCTSICSLYQLENYCN B:  FVNQHLCGSHLVEALYLVCGERGFFYTPKA C:  GIVEQCCTSICSLYQLENYCN D:  FVNQHLCGSHLVEALYLVCGERGFFYTPKA E:  GIVEQCCTSICSLYQLENYCN F:  FVNQHLCGSHLVEALYLVCGERGFFYTPKA G:  XXXXXXXXXXXXXXXX Description Functional site 1) chain B residue 5 type sequence H description M-CRESOL BINDING SITE. OH BINDS ON EACH MONOMER TO OA6 AND NHA11 VIA HYDROGEN BOND. IT IS BOUNDED BY B10 OF SAME MONOMER AND B5 OF A DIFFERENT ONE WITHIN THE SAME TRIMER. source : MCR 2) chain A residue 6 type sequence C description M-CRESOL BINDING SITE. OH BINDS ON EACH MONOMER TO OA6 AND NHA11 VIA HYDROGEN BOND. IT IS BOUNDED BY B10 OF SAME MONOMER AND B5 OF A DIFFERENT ONE WITHIN THE SAME TRIMER. source : MCR 3) chain A residue 11 type sequence C description M-CRESOL BINDING SITE. OH BINDS ON EACH MONOMER TO OA6 AND NHA11 VIA HYDROGEN BOND. IT IS BOUNDED BY B10 OF SAME MONOMER AND B5 OF A DIFFERENT ONE WITHIN THE SAME TRIMER. source : MCR 4) chain B residue 10 type sequence H description M-CRESOL BINDING SITE. OH BINDS ON EACH MONOMER TO OA6 AND NHA11 VIA HYDROGEN BOND. IT IS BOUNDED BY B10 OF SAME MONOMER AND B5 OF A DIFFERENT ONE WITHIN THE SAME TRIMER. source : MCR 5) chain B residue 10 type sequence H description BINDING SITE FOR RESIDUE ZN D 31 source : AC1 6) chain D residue 10 type sequence H description BINDING SITE FOR RESIDUE ZN D 31 source : AC1 7) chain F residue 10 type sequence H description BINDING SITE FOR RESIDUE ZN D 31 source : AC1 8) chain G residue 35 type sequence X description BINDING SITE FOR RESIDUE ZN D 31 source : AC1 9) chain E residue 6 type sequence C description BINDING SITE FOR RESIDUE CRS E 22 source : AC2 10) chain E residue 10 type sequence I description BINDING SITE FOR RESIDUE CRS E 22 source : AC2 11) chain E residue 11 type sequence C description BINDING SITE FOR RESIDUE CRS E 22 source : AC2 12) chain F residue 11 type sequence L description BINDING SITE FOR RESIDUE CRS E 22 source : AC2 13) chain G residue 39 type sequence X description BINDING SITE FOR RESIDUE CRS E 22 source : AC2 14) chain C residue 6 type sequence C description BINDING SITE FOR RESIDUE CRS C 22 source : AC3 15) chain C residue 10 type sequence I description BINDING SITE FOR RESIDUE CRS C 22 source : AC3 16) chain C residue 11 type sequence C description BINDING SITE FOR RESIDUE CRS C 22 source : AC3 17) chain C residue 16 type sequence L description BINDING SITE FOR RESIDUE CRS C 22 source : AC3 18) chain D residue 11 type sequence L description BINDING SITE FOR RESIDUE CRS C 22 source : AC3 19) chain D residue 14 type sequence A description BINDING SITE FOR RESIDUE CRS C 22 source : AC3 20) chain A residue 6 type sequence C description BINDING SITE FOR RESIDUE CRS A 22 source : AC4 21) chain A residue 10 type sequence I description BINDING SITE FOR RESIDUE CRS A 22 source : AC4 22) chain A residue 11 type sequence C description BINDING SITE FOR RESIDUE CRS A 22 source : AC4 23) chain B residue 7 type sequence C description BINDING SITE FOR RESIDUE CRS A 22 source : AC4 24) chain B residue 11 type sequence L description BINDING SITE FOR RESIDUE CRS A 22 source : AC4 25) chain B residue 14 type sequence A description BINDING SITE FOR RESIDUE CRS A 22 source : AC4 26) chain D residue 2 type sequence V description BINDING SITE FOR RESIDUE CRS A 22 source : AC4 27) chain D residue 5 type sequence H description BINDING SITE FOR RESIDUE CRS A 22 source : AC4 28) chain A residue 6-20 type prosite sequence CCTSICSLYQLENYC description INSULIN Insulin family signature. CCTSiCSlyqLenyC source prosite : PS00262

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