|
eF-site ID
|
7d4f-ABCG |
PDB Code
|
7d4f |
Chain
|
A, B, C, G |
|
click to enlarge
|
|
Title
|
Structure of COVID-19 RNA-dependent RNA polymerase bound to suramin |
Classification
|
VIRAL PROTEIN |
Compound
|
Non-structural protein 8 |
Source
|
(R1AB_SARS2) |
|
Sequence
|
A: |
SFLNRVCGVSAARLTPCVYRAFDIYNDKVAGFAKFLKTNC
CRFQEKDEDDNLIDSYFVVKRHTFSNYQHEETIYNLLKDC
PAVAKHDFFKFRIMVPHISRQRLTKYTMADLVYALRHFDE
GNCDTLKEILVTYNCCDDDYFNKKDWYDFVENPDILRVYA
NLGERVRQALLKTVQFCDAMRNAGIVGVLTLDNQDLNGNW
YDFGDFIQTTPGSGVPVVDSYYSLLMPILTLTRALTAESH
VDTDLTKPYIKWDLLKYDFTEERLKLFDRYFKYWDQTYHP
NCVNCLDDRCILHCANFNVLFSTVFPPTSFGPLVRKIFVD
GVPFVVSTGYHFRELGVVHNQDVNLHSSRLSFKELLVYAA
DPAMHAASGNLLLDKRTTCFSVAALTNNVAFQTVKPGNFN
KDFYDFAVSKGFFKEGSSVELKHFFFAQDGNAAISDYDYY
RYNLPTMCDIRQLLFVVEVVDKYFDCYDGGCINANQVIVN
NLDKSAGFPFNKWGKARLYYDSMSYEDQDALFAYTKRNVI
PTITQMNLKYAISAKNRARTVAGVSICSTMTNRQFHQKLL
KSIAATRGATVVIGTSKFYGGWHNMLKTVYSDVENPHLMG
WDYPKCDRAMPNMLRIMASLVLARKHTTCCSLSHRFYRLA
NECAQVLSEMVMCGGSLYVKPGGTSSGDATTAYANSVFNI
CQAVTANVNALLSTDGNKIADKYVRNLQHRLYECLYRNRD
VDTDFVNEFYAYLRKHFSMMILSDDAVVCFNSTYASQGLV
ASIKNFKSVLYYQNNVFMSEAKCWTETDLTKGPHEFCSQH
TMLVKQGDDYVYLPYPDPSRILGAGCFVDDIVKTDGTLMI
ERFVSLAIDAYPLTKHPNQEYADVFHLYLQYIRKLHDELN
TSRYWEPEFYEAMYTPHT
|
B: |
DKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPL
NIIPLTTAAKLMVVIPDYNTYKNTCDGTTFTYASALWEIQ
QVVDADSKIVQLSEISMDNSPNLAWPLIVTALRA
|
C: |
KMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILL
AKDTTEAFEKMVSLLSVLLSMQG
|
G: |
TSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLT
TAAKLMVVIPDYNTYKNTCDGTTFTYASALWEIQQVVDAD
SKIVQLSEISMDNSPNWPLIVTALRA
|
|
Description
|
|
Functional site
|
|
1)
|
chain |
A |
residue |
590-601 |
type |
prosite |
sequence |
GTSKFYGGWHNM
|
description |
LIPOCALIN Lipocalin signature. GTS..KFYGGWHNM
|
source |
prosite : PS00213
|
|
2)
|
chain |
A |
residue |
759 |
type |
ACT_SITE |
sequence |
S
|
description |
ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU01293
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
3)
|
chain |
A |
residue |
760 |
type |
ACT_SITE |
sequence |
D
|
description |
ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU01293
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
4)
|
chain |
A |
residue |
761 |
type |
ACT_SITE |
sequence |
D
|
description |
ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU01293
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
5)
|
chain |
A |
residue |
209 |
type |
BINDING |
sequence |
N
|
description |
BINDING => ECO:0000269|PubMed:33232691, ECO:0007744|PDB:7CYQ
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
6)
|
chain |
A |
residue |
218 |
type |
BINDING |
sequence |
D
|
description |
BINDING => ECO:0000269|PubMed:33232691, ECO:0007744|PDB:7CYQ
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
7)
|
chain |
A |
residue |
295 |
type |
BINDING |
sequence |
H
|
description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU01344, ECO:0000269|PubMed:32358203, ECO:0000269|PubMed:32526208, ECO:0000269|PubMed:33232691, ECO:0007744|PDB:7CYQ
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
8)
|
chain |
A |
residue |
301 |
type |
BINDING |
sequence |
C
|
description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU01344, ECO:0000269|PubMed:32358203, ECO:0000269|PubMed:32526208, ECO:0000269|PubMed:33232691, ECO:0007744|PDB:7CYQ
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
9)
|
chain |
A |
residue |
306 |
type |
BINDING |
sequence |
C
|
description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU01344, ECO:0000269|PubMed:32358203, ECO:0000269|PubMed:32526208, ECO:0000269|PubMed:33232691, ECO:0007744|PDB:7CYQ
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
10)
|
chain |
A |
residue |
310 |
type |
BINDING |
sequence |
C
|
description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU01344, ECO:0000269|PubMed:32358203, ECO:0000269|PubMed:32526208, ECO:0000269|PubMed:33232691, ECO:0007744|PDB:7CYQ
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
11)
|
chain |
A |
residue |
487 |
type |
BINDING |
sequence |
C
|
description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU01293, ECO:0000269|PubMed:32358203, ECO:0000269|PubMed:32526208, ECO:0000269|PubMed:33232691, ECO:0007744|PDB:7CYQ
|
source |
Swiss-Prot : SWS_FT_FI4
|
|
12)
|
chain |
A |
residue |
642 |
type |
BINDING |
sequence |
H
|
description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU01293, ECO:0000269|PubMed:32358203, ECO:0000269|PubMed:32526208, ECO:0000269|PubMed:33232691, ECO:0007744|PDB:7CYQ
|
source |
Swiss-Prot : SWS_FT_FI4
|
|
13)
|
chain |
A |
residue |
646 |
type |
BINDING |
sequence |
C
|
description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU01293, ECO:0000269|PubMed:32358203, ECO:0000269|PubMed:32526208, ECO:0000269|PubMed:33232691, ECO:0007744|PDB:7CYQ
|
source |
Swiss-Prot : SWS_FT_FI4
|
|
14)
|
chain |
A |
residue |
645 |
type |
BINDING |
sequence |
C
|
description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU01293, ECO:0000269|PubMed:32358203, ECO:0000269|PubMed:32526208, ECO:0000269|PubMed:33232691
|
source |
Swiss-Prot : SWS_FT_FI5
|
|
|
|