eF-site ID 7bzf-ABCD PDB Code 7bzf Chain A, B, C, D click to enlarge Title COVID-19 RNA-dependent RNA polymerase post-translocated catalytic complex Classification VIRAL PROTEIN/RNA Compound RNA-directed RNA polymerase Source (7BZF) Sequence A:  SADAQSFLNRVCGVSAARLTPCGTGTSTDVVYRAFDIYND KVAGFAKFLKTNCCRFQEKDEDDNLIDSYFVVKRHTFSNY QHEETIYNLLKDCPAVAKHDFFKFRIDGDMVPHISRQRLT KYTMADLVYALRHFDEGNCDTLKEILVTYNCCDDDYFNKK DWYDFVENPDILRVYANLGERVRQALLKTVQFCDAMRNAG IVGVLTLDNQDLNGNWYDFGDFIQTTPGSGVPVVDSYYSL LMPILTLTRALTAESHVDTDLTKPYIKWDLLKYDFTEERL KLFDRYFKYWDQTYHPNCVNCLDDRCILHCANFNVLFSTV FPPTSFGPLVRKIFVDGVPFVVSTGYHFRELGVVHNQDVN LHSSRLSFKELLVYAADPAMHAASGNLLLDKRTTCFSVAA LTNNVAFQTVKPGNFNKDFYDFAVSKGFFKEGSSVELKHF FFAQDGNAAISDYDYYRYNLPTMCDIRQLLFVVEVVDKYF DCYDGGCINANQVIVNNLDKSAGFPFNKWGKARLYYDSMS YEDQDALFAYTKRNVIPTITQMNLKYAISAKNRARTVAGV SICSTMTNRQFHQKLLKSIAATRGATVVIGTSKFYGGWHN MLKTVYSDVENPHLMGWDYPKCDRAMPNMLRIMASLVLAR KHTTCCSLSHRFYRLANECAQVLSEMVMCGGSLYVKPGGT SSGDATTAYANSVFNICQAVTANVNALLSTDGNKIADKYV RNLQHRLYECLYRNRDVDTDFVNEFYAYLRKHFSMMILSD DAVVCFNSTYASQGLVASIKNFKSVLYYQNNVFMSEAKCW TETDLTKGPHEFCSQHTMLVKQGDDYVYLPYPDPSRILGA GCFVDDIVKTDGTLMIERFVSLAIDAYPLTKHPNQEYADV FHLYLQYIRKLHDELTTSRYWEPEFYEAMYTPHT B:  KRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLN IIPLTTAAKLMVVIPDYNTYKNTCDGTTFTYASALWEIQQ VVDADSKIVQLSEISMDNSPNLAWPLIVTALRAN C:  SKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDIL LAKDTTEAFEKMVSLLSVLLSMQGAVDI D:  TSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLK LMVVIPDYNTYKNTCDGTTFTYASALWEIQQVVDADSKIV QLSEISMDNSPNLAWPLIVTALRA Description Functional site 1) chain A residue 295 type sequence H description binding site for residue ZN A 1001 source : AC1 2) chain A residue 301 type sequence C description binding site for residue ZN A 1001 source : AC1 3) chain A residue 306 type sequence C description binding site for residue ZN A 1001 source : AC1 4) chain A residue 310 type sequence C description binding site for residue ZN A 1001 source : AC1 5) chain A residue 487 type sequence C description binding site for residue ZN A 1002 source : AC2 6) chain A residue 571 type sequence F description binding site for residue ZN A 1002 source : AC2 7) chain A residue 642 type sequence H description binding site for residue ZN A 1002 source : AC2 8) chain A residue 645 type sequence C description binding site for residue ZN A 1002 source : AC2 9) chain A residue 646 type sequence C description binding site for residue ZN A 1002 source : AC2 10) chain A residue 645 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU01293, ECO:0000269|PubMed:32358203, ECO:0000269|PubMed:32526208, ECO:0000269|PubMed:33232691 source Swiss-Prot : SWS_FT_FI5 11) chain A residue 642 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU01293, ECO:0000269|PubMed:32358203, ECO:0000269|PubMed:32526208, ECO:0000269|PubMed:33232691, ECO:0007744|PDB:7CYQ source Swiss-Prot : SWS_FT_FI4 12) chain A residue 646 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU01293, ECO:0000269|PubMed:32358203, ECO:0000269|PubMed:32526208, ECO:0000269|PubMed:33232691, ECO:0007744|PDB:7CYQ source Swiss-Prot : SWS_FT_FI4 13) chain A residue 487 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU01293, ECO:0000269|PubMed:32358203, ECO:0000269|PubMed:32526208, ECO:0000269|PubMed:33232691, ECO:0007744|PDB:7CYQ source Swiss-Prot : SWS_FT_FI4 14) chain A residue 590-601 type prosite sequence GTSKFYGGWHNM description LIPOCALIN Lipocalin signature. GTS..KFYGGWHNM source prosite : PS00213 15) chain A residue 761 type SITE sequence D description Cleavage; by 3CL-PRO => ECO:0000250|UniProtKB:P0C6V3 source Swiss-Prot : SWS_FT_FI1 16) chain A residue 209 type BINDING sequence N description BINDING => ECO:0000269|PubMed:33232691, ECO:0007744|PDB:7CYQ source Swiss-Prot : SWS_FT_FI2 17) chain A residue 218 type BINDING sequence D description BINDING => ECO:0000269|PubMed:33232691, ECO:0007744|PDB:7CYQ source Swiss-Prot : SWS_FT_FI2 18) chain A residue 306 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU01344, ECO:0000269|PubMed:32358203, ECO:0000269|PubMed:32526208, ECO:0000269|PubMed:33232691, ECO:0007744|PDB:7CYQ source Swiss-Prot : SWS_FT_FI3 19) chain A residue 301 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU01344, ECO:0000269|PubMed:32358203, ECO:0000269|PubMed:32526208, ECO:0000269|PubMed:33232691, ECO:0007744|PDB:7CYQ source Swiss-Prot : SWS_FT_FI3 20) chain A residue 310 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU01344, ECO:0000269|PubMed:32358203, ECO:0000269|PubMed:32526208, ECO:0000269|PubMed:33232691, ECO:0007744|PDB:7CYQ source Swiss-Prot : SWS_FT_FI3 21) chain A residue 295 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU01344, ECO:0000269|PubMed:32358203, ECO:0000269|PubMed:32526208, ECO:0000269|PubMed:33232691, ECO:0007744|PDB:7CYQ source Swiss-Prot : SWS_FT_FI3

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