|
eF-site ID
|
6yyt-ABCDPQTU |
PDB Code
|
6yyt |
Chain
|
A, B, C, D, P, Q, T, U |
|
click to enlarge
|
|
Title
|
Structure of replicating SARS-CoV-2 polymerase |
Classification
|
VIRAL PROTEIN |
Compound
|
nsp12 |
Source
|
(6YYT) |
|
Sequence
|
A: |
VYRAFDIYNDKVAGFAKFLKFSNYQHEETIYNLLKDCPAV
ARLTKYTMADLVYALRHFDEGNCDTLKEILVTYNCCDDDY
FNKKDWYDFVENPDILRVYANLGERVRQALLKTVQFCDAM
RNAGIVGVLTLDNQDLNGNWYDFGDFIQTTPGSGVPVVDS
YYSLLMPILTLTRALTAESHVDTDLTKPYIKWDLLKYDFT
EERLKLFDRYFKYWDQTYHPNCVNCLDDRCILHCANFNVL
FSTVFPPTSFGPLVRKIFVDGVPFVVSTGYHFRELGVVHN
QDVNLHSSRLSFKELLVYAADPAMHAASGNLLLDKRTTCF
SVAALTNNVAFQTVKPGNFNKDFYDFAVSKGFFKEGSSVE
LKHFFFAQDGNAAISDYDYYRYNLPTMCDIRQLLFVVEVV
DKYFDCYDGGCINANQVIVNNLDKSAGFPFNKWGKARLYY
DSMSYEDQDALFAYTKRNVIPTITQMNLKYAISAKNRART
VAGVSICSTMTNRQFHQKLLKSIAATRGATVVIGTSKFYG
GWHNMLKTVYSDVENPHLMGWDYPKCDRAMPNMLRIMASL
VLARKHTTCCSLSHRFYRLANECAQVLSEMVMCGGSLYVK
PGGTSSGDATTAYANSVFNICQAVTANVNALLSTDGNKIA
DKYVRNLQHRLYECLYRNRDVDTDFVNEFYAYLRKHFSMM
ILSDDAVVCFNSTYASQGLVASIKNFKSVLYYQNNVFMSE
AKCWTETDLTKGPHEFCSQHTMLVKQGDDYVYLPYPDPSR
ILGAGCFVDDIVKTDGTLMIERFVSLAIDAYPLTKHPNQE
YADVFHLYLQYIRKLHDELTGHMLDMYSVMLTNDNTSRYW
EPEFYEAMYTPHT
|
B: |
FSSLPSYAAFATAQEAYEQAVANGDSEVVLKKLKKSLNVA
KSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTS
AMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTA
AKLMVVIPDYNTYKNTCDGTTFTYASALWEIQQVVDADSK
IVQLSEISMDNSPNLAWPLIVTALRA
|
C: |
SKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDIL
LAKDTTEAFEKMVSLLSVLLSMQGAVDINKLCE
|
D: |
FSSLPSYAAFATAQEAYEQAVANGDSEVVLKKLKKSLNVA
KSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTS
AMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTA
AKLMVVIPDYNTYKNTCDGTTFTYASALWEIQQVVDADSK
IVQLSEISMDNSPNLAWPLIVTALRA
|
P: |
CAUGCUACGCGUAG
|
Q: |
CAUGCUACGCGUAG
|
T: |
UGCUACGCGUAG
|
U: |
CAUGCUACGCGUAG
|
|
Description
|
|
Functional site
|
|
1)
|
chain |
A |
residue |
295 |
type |
|
sequence |
H
|
description |
binding site for residue ZN A 2000
|
source |
: AC1
|
|
2)
|
chain |
A |
residue |
301 |
type |
|
sequence |
C
|
description |
binding site for residue ZN A 2000
|
source |
: AC1
|
|
3)
|
chain |
A |
residue |
306 |
type |
|
sequence |
C
|
description |
binding site for residue ZN A 2000
|
source |
: AC1
|
|
4)
|
chain |
A |
residue |
310 |
type |
|
sequence |
C
|
description |
binding site for residue ZN A 2000
|
source |
: AC1
|
|
5)
|
chain |
A |
residue |
487 |
type |
|
sequence |
C
|
description |
binding site for residue ZN A 2001
|
source |
: AC2
|
|
6)
|
chain |
A |
residue |
642 |
type |
|
sequence |
H
|
description |
binding site for residue ZN A 2001
|
source |
: AC2
|
|
7)
|
chain |
A |
residue |
645 |
type |
|
sequence |
C
|
description |
binding site for residue ZN A 2001
|
source |
: AC2
|
|
8)
|
chain |
A |
residue |
646 |
type |
|
sequence |
C
|
description |
binding site for residue ZN A 2001
|
source |
: AC2
|
|
9)
|
chain |
A |
residue |
590-601 |
type |
prosite |
sequence |
GTSKFYGGWHNM
|
description |
LIPOCALIN Lipocalin signature. GTS..KFYGGWHNM
|
source |
prosite : PS00213
|
|
10)
|
chain |
A |
residue |
761 |
type |
SITE |
sequence |
D
|
description |
Cleavage; by 3CL-PRO => ECO:0000250|UniProtKB:P0C6V3
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
11)
|
chain |
A |
residue |
209 |
type |
BINDING |
sequence |
N
|
description |
BINDING => ECO:0000269|PubMed:33232691, ECO:0007744|PDB:7CYQ
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
12)
|
chain |
A |
residue |
218 |
type |
BINDING |
sequence |
D
|
description |
BINDING => ECO:0000269|PubMed:33232691, ECO:0007744|PDB:7CYQ
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
13)
|
chain |
A |
residue |
295 |
type |
BINDING |
sequence |
H
|
description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU01344, ECO:0000269|PubMed:32358203, ECO:0000269|PubMed:32526208, ECO:0000269|PubMed:33232691, ECO:0007744|PDB:7CYQ
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
14)
|
chain |
A |
residue |
301 |
type |
BINDING |
sequence |
C
|
description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU01344, ECO:0000269|PubMed:32358203, ECO:0000269|PubMed:32526208, ECO:0000269|PubMed:33232691, ECO:0007744|PDB:7CYQ
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
15)
|
chain |
A |
residue |
306 |
type |
BINDING |
sequence |
C
|
description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU01344, ECO:0000269|PubMed:32358203, ECO:0000269|PubMed:32526208, ECO:0000269|PubMed:33232691, ECO:0007744|PDB:7CYQ
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
16)
|
chain |
A |
residue |
310 |
type |
BINDING |
sequence |
C
|
description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU01344, ECO:0000269|PubMed:32358203, ECO:0000269|PubMed:32526208, ECO:0000269|PubMed:33232691, ECO:0007744|PDB:7CYQ
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
17)
|
chain |
A |
residue |
487 |
type |
BINDING |
sequence |
C
|
description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU01293, ECO:0000269|PubMed:32358203, ECO:0000269|PubMed:32526208, ECO:0000269|PubMed:33232691, ECO:0007744|PDB:7CYQ
|
source |
Swiss-Prot : SWS_FT_FI4
|
|
18)
|
chain |
A |
residue |
642 |
type |
BINDING |
sequence |
H
|
description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU01293, ECO:0000269|PubMed:32358203, ECO:0000269|PubMed:32526208, ECO:0000269|PubMed:33232691, ECO:0007744|PDB:7CYQ
|
source |
Swiss-Prot : SWS_FT_FI4
|
|
19)
|
chain |
A |
residue |
646 |
type |
BINDING |
sequence |
C
|
description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU01293, ECO:0000269|PubMed:32358203, ECO:0000269|PubMed:32526208, ECO:0000269|PubMed:33232691, ECO:0007744|PDB:7CYQ
|
source |
Swiss-Prot : SWS_FT_FI4
|
|
20)
|
chain |
A |
residue |
645 |
type |
BINDING |
sequence |
C
|
description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU01293, ECO:0000269|PubMed:32358203, ECO:0000269|PubMed:32526208, ECO:0000269|PubMed:33232691
|
source |
Swiss-Prot : SWS_FT_FI5
|
|
|
|