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|
eF-site ID
|
6yum-.AAA.GGG |
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PDB Code
|
6yum |
|
Chain
|
AAA, GGG |
|
click to enlarge
|
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|
Title
|
CK2 alpha bound to unclosed Macrocycle |
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Classification
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TRANSFERASE |
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Compound
|
Casein kinase II subunit alpha |
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Source
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(CSK21_HUMAN) |
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Sequence
|
AAA: |
GPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLV
RKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREI
KILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFK
QLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNV
MIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPEL
LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQL
VRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWE
RFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHP
YFYTVVKDQAR
|
| GGG: |
GPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLV
RKLGREVFEAINITNNEKVVVKILKPVKKKKIKREIKILE
NLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ
TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDH
EHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY
QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIA
KVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVH
SENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT
VVKDQ
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Description
|
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Functional site
|
|
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1)
|
chain |
AAA |
| residue |
156 |
| type |
ACT_SITE |
| sequence |
D
|
| description |
Proton acceptor
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
2)
|
chain |
GGG |
| residue |
156 |
| type |
ACT_SITE |
| sequence |
D
|
| description |
Proton acceptor
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
3)
|
chain |
AAA |
| residue |
45 |
| type |
BINDING |
| sequence |
L
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
4)
|
chain |
AAA |
| residue |
68 |
| type |
BINDING |
| sequence |
K
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
5)
|
chain |
GGG |
| residue |
45 |
| type |
BINDING |
| sequence |
L
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
6)
|
chain |
GGG |
| residue |
68 |
| type |
BINDING |
| sequence |
K
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
7)
|
chain |
AAA |
| residue |
45-68 |
| type |
prosite |
| sequence |
LGRGKYSEVFEAINITNNEKVVVK
|
| description |
PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGRGKYSEVFeAinitnnek..........VVVK
|
| source |
prosite : PS00107
|
|
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8)
|
chain |
AAA |
| residue |
152-164 |
| type |
prosite |
| sequence |
IMHRDVKPHNVMI
|
| description |
PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ImHrDVKphNVMI
|
| source |
prosite : PS00108
|
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