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eF-site ID
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6y7m-.AAA |
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PDB Code
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6y7m |
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Chain
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AAA |
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click to enlarge
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Title
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Crystal structure of the complex resulting from the reaction between the SARS-CoV main protease and tert-butyl (1-((S)-3-cyclohexyl-1-(((S)-4-(cyclopropylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)amino)-1-oxopropan-2-yl)-2-oxo-1,2-dihydropyridin-3-yl)carbamate |
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Classification
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VIRAL PROTEIN |
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Compound
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3C-like proteinase |
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Source
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(R1A_SARS) |
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Sequence
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AAA: |
SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPR
HVICTAEDMLNPNYEDLLIRKSNHSFLVQAGNVQLRVIGH
SMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNG
SPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTI
TLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRT
ILGSTILEDEFTPFDVVRQCSGVTFQ
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Description
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Functional site
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1)
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chain |
AAA |
| residue |
306 |
| type |
SITE |
| sequence |
Q
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| description |
Cleavage; by 3CL-PRO => ECO:0000269|PubMed:14561748
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| source |
Swiss-Prot : SWS_FT_FI3
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2)
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chain |
AAA |
| residue |
41 |
| type |
ACT_SITE |
| sequence |
H
|
| description |
For 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772, ECO:0000269|PubMed:16306590
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| source |
Swiss-Prot : SWS_FT_FI1
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3)
|
chain |
AAA |
| residue |
145 |
| type |
ACT_SITE |
| sequence |
C
|
| description |
For 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772
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| source |
Swiss-Prot : SWS_FT_FI2
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