Title
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Cryo-EM structure of an Escherichia coli 70S ribosome in complex with antibiotic TetracenomycinX |
Classification
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RIBOSOME |
Compound
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16S ribosomal RNA |
Source
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ORGANISM_SCIENTIFIC: Escherichia coli (strain K12); |
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Sequence
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0: |
AVQQNKPTRSKRGMRRSHDALTAVTSLSVDKTSGEKHLRH
HITADGYYRGRKVIAK
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1: |
GIREKIKLVSSAGTGHFYTTTKNKRTKPEKLELKKFDPVV
RQHVIYKEAK
|
2: |
MKRTFQPSVLKRNRSHGFRARMATKNGRQVLARRRAKGRA
RLTVSK
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3: |
PKIKTVRGAAKRFKKTGKGGFKHKHANLRHILTKKATKRK
RHLRPKAMVSKGDLGLVIACLPYA
|
4: |
MKVRASVKKLCRNCKIVKRDGVIRVICSAEPKHKQRQG
|
6: |
MKKDIHPKYEEITASCSCGNVMKIRSTVGHDLNLDVCSKC
HPFFTGKQRDVATGGRVDRFNKRFNI
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C: |
AVVKCKPTSPGRRHVVKVVNPELHKGKPFAPLLEKNSKSG
GRNNNGRITTRHIGGGHKQAYRIVDFKRNKDGIPAVVERL
EYDPNRSANIALVLYKDGERRYILAPKGLKAGDQIQSGVD
AAIKPGNTLPMRNIPVGSTVHNVEMKPGKGGQLARSAGTY
VQIVARDGAYVTLRLRSGEMRKVEADCRATLGEVGNAEHM
LRVLGKAGAARWRGVRPTVRGTAMNPVDHPHGGGEGRNFG
KHPVTPWGVQTKGKKTRSNKRTDKFIVRRRS
|
D: |
MIGLVGKKVGMTRIFTEDGVSIPVTVIEVEANRVTQVKDL
ANDGYRAIQVTTGAKKANRVTKPEAGHFAKAGVEAGRGLW
EFRLAEGEEFTVGQSISVELFADVKKVDVTGTSKGKGFAG
TVKRWNFRTQDATHGNSLSHRVPGSIGQNQTPGKVFKGKK
MAGQMGNERVTVQSLDVVRVDAERNLLLVKGAVPGATGSD
LIVKPAVKA
|
E: |
MELVLKDAQSALTVSETTFGRDFNEALVHQVVVAYAAGAR
QGTRAQKTRAEVTGSGKKPWRQKGTGRARSGSIKSPIWRS
GGVTFAARPQDHSQKVNKKMYRGALKSILSELVRQDRLIV
VEKFSVEAPKTKLLAQKLKDMALEDVLIITGELDENLFLA
ARNLHKVDVRDATGIDPVSLIAFDKVVMTADAVKQVEEML
A
|
F: |
AKLHDYYKDEVVKKLMTEFNYNSVMQVPRVEKITLNMGVG
EAIADKKLLDNAAADLAAISGQKPLITKARKSVAGFKIRQ
GYPIGCKVTLRGERMWEFFERLITIAVPRIRDFRGLSAKS
FDGRGNYSMGVREQIIFPEIDYDKVDRVRGLDITITTTAK
SDEEGRALLAAFDFPFR
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G: |
SRVAKAPVVVPAGVDVKINGQVITIKGKNGELTRTLNDAV
EVKHADNTLTFGPRDGYADGWAQAGTARALLNSMVIGVTE
GFTKKLQLVGVGYRAAVKGNVINLSLGFSHPVDHQLPAGI
TAECPTQTEIVLKGADKQVIGQVAADLRAYRRPEPYKGKG
VRYADEVVRTKEAKKK
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H: |
KINALETVTIASKAGDEGKLFGSIGTRDIADAVTAAGVEV
AKSEVRLPNGVLRTTGEHEVSFQVHSEVFAKVIVNVVAE
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J: |
MKTFTAKPETVKRDWYVVDATGKTLGRLATELARRLRGKH
KAEYTPHVDTGDYIIVLNADKVAVTGNKRTDKVYYHHTGH
IGGIKQATFEEMIARRPERVIEIAVKGMLPKGPLGRAMFR
KLKVYAGNEHNHAAQQPQVLDI
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K: |
MIQEQTMLNVADNSGARRVMCIKVLGGSHRRYAGVGDIIK
ITIKEAIPRGKVKKGDVLKAVVVRTKKGVRRPDGSVIRFD
GNACVLLNNNSEQPIGTRIFGPVTRELRSEKFMKIISLAP
EV
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L: |
RLNTLSPAEGSKKAGKRLGRGIGSGLGKTGGRGHKGQKSR
SGGGVRRGFEGGQMPLYRRLPKFGFTSRKAAITAEIRLSD
LAKVEGGVVDLNTLKAANIIGIQIEFAKVILAGEVTTPVT
VRGLRVTKGARAAIEAAGGKIEE
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M: |
MLQPKRTKFRKMHKGRNRGLAQGTDVSFGSFGLKAVGRGR
LTARQIEAARRAMTRAVKRQGKIWIRVFPDKPITEKPLAV
RMGKGKGNVEYWVALIQPGKVLYEMDGVPEELAREAFKLA
AAKLPIKTTFVTKTVM
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N: |
MRHRKSGRQLNRNSSHRQAMFRNMAGSLVRHEIIKTTLPK
AKELRRVVEPLITLAKTDSVANRRLAFARTRDNEIVAKLF
NELGPRFASRAGGYTRILKCGFRAGDNAPMAYIELVDRSE
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O: |
DKKSARIRRATRARRKLQELGATRLVVHRTPRHIYAQVIA
PNGSEVLVAASTVEKAIAEQLKYTGNKDAAAAVGKAVAER
ALEKGIKDVSFDRSGFQYHGRVQALADAAREAGLQF
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P: |
SNIIKQLEQEQMKQDVPSFRPGDTVEVKVWVVEGSKKRLQ
AFEGVVIAIRNRGLHSAFTVRKISNGEGVERVFQTHSPVV
DSISVKRRGAVRKAKLYYLRERTGKAARIKERLN
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Q: |
ARVKRGVIARARHKKILKQAKGYYGARSRVYRVAFQAVIK
AGQYAYRDRRQRKRQFRQLWIARINAAARQNGISYSKFIN
GLKKASVEIDRKILADIAVFDKVAFTALVEKAKAALA
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R: |
MYAVFQSGGKQHRVSEGQTVRLEKLDIATGETVEFAEVLM
IANGEEVKIGVPFVDGGVIKAEVVAHGRGEKVKIVKFRRR
KHYRKQQGHRQWFTDVKITGISA
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S: |
METIAKHRHARSSAQKVRLVADLIRGKKVSQALDILTYTN
KKAAVLVKKVLESAIANAEHNDGADIDDLKVTKIFVDEGP
SMKRIMPRAKGRADRILKRTSHITVVVSDR
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T: |
MIREERLLKVLRAPHVSEKASTAMEKSNTIVLKVAKDATK
AEIKAAVQKLFEVEVEVVNTLVVKGKVKRHGQRIGRRSDW
KKAYVTLKEGQNL
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U: |
AAKIRRDDEVIVLTGKDKGKRGKVKNVLSSGKVIVEGINL
VKKHQKPVPALNQPGGIVEKEAAIQVSNVAIFNAATGKAD
RVGFRFEDGKKVRFFKSNSETI
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V: |
MFTINAEVRKEQGKGASRRLRAANKFPAIIYGGKEAPLAI
ELDHDKVMNMQAKAEFYSEVLTIVVDGKEIKVKAQDVQRH
PYKPKLQHIDFVRA
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W: |
RNGRDSEAKRLGVKRFGGESVLAGSIIVRQRGTKFHAGAN
VGCGRDHTLFAKADGKVKFEVKGPKNRKFISIEAE
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X: |
SRVCQVTGKRPVTGNNRSHALNATKRRFLPNLHSHRFWVE
SEKRFVTLRVSAKGMRVIDKKGIDTVLAELRARGEKY
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Y: |
MKAKELREKSVEELNTELLNLLREQFNLRMQAASGQLQQS
HLLKQVRRDVARVKTLLNEKAGA
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Z: |
AKTIKITQTRSAIGRLPKHKATLLGLGLRRIGHTVEREDT
PAIRGMINAVSFMVKVEE
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b: |
MLKAGVHFGHQTRYWNPKMKPFIFGARNKVHIINLEKTVP
MFNEALAELNKIASRKGKILFVGTKRAASEAVKDAALSCD
QFFVNHRWLGGMLTNWKTVRQSIKRLKDLETQSQDGTFDK
LTKKEALMRTRELEKLENSLGGIKDMGGLPDALFVIDADH
EHIAIKEANNLGIPVFAIVDTNSDPDGVDFVIPGNDDAIR
AVTLYLGAVAATVREGRS
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c: |
GQKVHPNGIRLGIVKPWNSTWFANTKEFADNLDSDFKVRQ
YLTKELAKASVSRIVIERPAKSIRVTIHTARPGIVIGKKG
EDVEKLRKVVADIAGVPAQINIAEVRKPELDAKLVADSIT
SQLERRVMFRRAMKRAVQNAMRLGAKGIKVEVSGRLGGAE
IARTEWYREGRVPLHTLRADIDYNTSEAHTTYGVIGVKVW
IFKGEI
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d: |
ARYLGPKLKLSRREGTDLFLKSGVRAIDTKCKIEQAPGQH
GARKPRLSDYGVQLREKQKVRRIYGVLERQFRNYYKEAAR
LKGNTGENLLALLEGRLDNVVYRMGFGATRAEARQLVSHK
AIMVNGRVVNIASYQVSPNDVVSIREKAKKQSRVKAALEL
AEQREKPTWLEVDAGKMEGTFKRKPERSDLSADINEHLIV
ELYSK
|
e: |
ELQEKLIAVNRVSKTVKGGRIFSFTALTVVGDGNGRVGFG
YGKAREVPAAIQKAMEKARRNMINVALNNGTLQHPVKGVH
TGSRVFMQPASEGTGIIAGGAMRAVLEVAGVHNVLAKAYG
STNPINVVRATIDGLENMNSPEMVAAKRGKSVEEILG
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f: |
MRHYEIVFMVHPDQSEQVPGMIERYTAAITGAEGKIHRLE
DWGRRQLAYPINKLHKAHYVLMNVEAPQEVIDELETTFRF
NDAVIRSMVMRTKHAVTEAS
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g: |
PRRRVIGQRKILPDPKFGSELLAKFVNILMVDGKKSTAES
IVYSALETLAQRSGKSELEAFEVALENVRPTVEVKSRRVG
GSTYQVPVEVRPVRRNALAMRWIVEAARKRGDKSMALRLA
NELSDAAENKGTAVKKREDVHRMAEANKAFAHYRW
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h: |
SMQDPIADMLTRIRNGQAANKAAVTMPSSKLKVAIANVLK
EEGFIEDFKVEGDTKPELELTLKYFQGKAVVESIQRVSRP
GLRIYKRKDELPKVMAGLGIAVVSTSKGVMTDRAARQAGL
GGEIICYVA
|
i: |
NQYYGTGRRKSSAARVFIKPGNGKIVINQRSLEQYFGRET
ARMVVRQPLELVDMVEKLDLYITVKGGGISGQAGAIRHGI
TRALMEYDESLRSELRKAGFVTRDARQVERKKVGLRKARR
RPQFSKR
|
j: |
RIRIRLKAFDHRLIDQATAEIVETAKRTGAQVRGPIPLPT
RKERFTVLISPHVNKDARDQYEIRTHLRLVDIVEPTEKTV
DALMRLDLAAGVDVQISL
|
k: |
RKQVSDGVAHIHASFNNTIVTITDRQGNALGWATAGGSGF
RGSRKSTPFAAQVAAERCADAVKEYGIKNLEVMVKGPGPG
RESTIRALNAAGFRITNITDVTPIPHNGCRPPKKRR
|
l: |
ATVNQLVRKPRARKVAKSNVPALEACPQKRGVCTRVYTTT
PKKPNSALRKVCRVRLTNGFEVTSYIGGEGHNLQEHSVIL
IRGGRVKDLPGVRYHTVRGALDCSGVKDRKQARSKYGVKR
PKA
|
m: |
ARIAGINIPDHKHAVIALTSIYGVGKTRSKAILAAAGIAE
DVKISELSEGQIDTLRDEVAKFVVEGDLRREISMSIKRLM
DLGCYRGLRHRRGLPVRGQRTKTNARTRKGPRKP
|
n: |
AKQSMKAREVKRVALADKYFAKRAELKAIISDVNAASDED
RWNAVLKLQTLPRDSSPSRQRNRCRQTGRPHGFLRKFGLS
RIKVREAAMRGEIPGLKKASW
|
o: |
SLSTEATAKIVSEFGRDANDTGSTEVQVALLTAQINHLQG
HFAEHKKDHHSRRGLLRMVSQRRKLLDYLKRKDVARYTQL
IERLGLRR
|
p: |
MVTIRLARHGAKKRPFYQVVVADSRNARNGRFIERVGFFN
PIASEKEEGTRLDLDRIAHWVGQGATISDRVAALIKEVNK
AA
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q: |
KIRTLQGRVVSDKMEKSIVVAIERFVKHPIYGKFIKRTTK
LHVHDENNECGIGDVVEIRECRPLSKTKSWTLVRVVEKAV
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r: |
FCRFTAEGVQEIDYKDIATLKNYITESGKIVPSRITGTRA
KYQRQLARAIKRARYLSLLPYTDRH
|
s: |
RSLKKGPFIDLHLLKKVEKAVESGDKKPLRTWSRRSTIFP
NMIGLTIAVHNGRQHVPVFVTDEMVGHKLGEFAPTRTYR
|
t: |
NIKSAKKRAIQSEKARKHNASRRSMMRTFIKKVYAAIEAG
DKAAAQKAFNEMQPIVDRQAAKGLIHKNKAARHKANLTAQ
INKLA
|
u: |
IKVRENEPFDVALRRFKRSCEKAGVLAEVRRREFYEKPTT
ERKRAKASAVKRHAKKLARENARRT
|
x: |
MQLNITGNNVEITEALREFVTAKFAKLEQYFDRINQVYVV
LKVEKVTHTSDATLHVDGGELHASAEGQDMYAAIDGLIDK
LARQLTKHKDKLKQH
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Description
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