eF-site ID 6xoa-C PDB Code 6xoa Chain C click to enlarge Title The crystal structure of 3CL MainPro of SARS-CoV-2 with C145S mutation Classification HYDROLASE Compound 3C-like proteinase Source (R1AB_SARS2) Sequence C:  SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPR HVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNG SPSGVYQCAMRPNFTIKGSFLNGSSGSVGFNIDYDCVSFC YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTI TVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRT ILGSALLEDEFTPFDVVRQCSGVTFQ Description Functional site 1) chain C residue 4 type sequence R description binding site for residue EDO C 401 source : AC2 2) chain C residue 5 type sequence K description binding site for residue EDO C 401 source : AC2 3) chain C residue 5 type sequence K description binding site for residue EDO D 401 source : AC3 4) chain C residue 126 type sequence Y description binding site for residue EDO D 401 source : AC3 5) chain C residue 41 type ACT_SITE sequence H description For 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772, ECO:0000305|PubMed:32198291 source Swiss-Prot : SWS_FT_FI1 6) chain C residue 145 type ACT_SITE sequence S description Nucleophile; for 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772, ECO:0000269|PubMed:32198291 source Swiss-Prot : SWS_FT_FI2 7) chain C residue 306 type SITE sequence Q description Cleavage; by 3CL-PRO => ECO:0000250|UniProtKB:P0C6V3 source Swiss-Prot : SWS_FT_FI3

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