|
eF-site ID
|
6xoa-B |
PDB Code
|
6xoa |
Chain
|
B |
|
click to enlarge
|
|
Title
|
The crystal structure of 3CL MainPro of SARS-CoV-2 with C145S mutation |
Classification
|
HYDROLASE |
Compound
|
3C-like proteinase |
Source
|
(R1AB_SARS2) |
|
Sequence
|
B: |
SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPR
HVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNG
SPSGVYQCAMRPNFTIKGSFLNGSSGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTI
TVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRT
ILGSALLEDEFTPFDVVRQCSGVTFQ
|
|
Description
|
|
Functional site
|
|
1)
|
chain |
B |
residue |
5 |
type |
|
sequence |
K
|
description |
binding site for residue EDO A 401
|
source |
: AC1
|
|
2)
|
chain |
B |
residue |
127 |
type |
|
sequence |
Q
|
description |
binding site for residue EDO A 401
|
source |
: AC1
|
|
3)
|
chain |
B |
residue |
41 |
type |
ACT_SITE |
sequence |
H
|
description |
For 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772, ECO:0000305|PubMed:32198291
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
4)
|
chain |
B |
residue |
145 |
type |
ACT_SITE |
sequence |
S
|
description |
Nucleophile; for 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772, ECO:0000269|PubMed:32198291
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
5)
|
chain |
B |
residue |
306 |
type |
SITE |
sequence |
Q
|
description |
Cleavage; by 3CL-PRO => ECO:0000250|UniProtKB:P0C6V3
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
|
|