eF-site ID 6xmk-A PDB Code 6xmk Chain A click to enlarge Title 1.70 A resolution structure of SARS-CoV-2 3CL protease in complex with inhibitor 7j Classification HYDROLASE/HYDROLASE INHIBITOR Compound 3C-like proteinase Source (R1AB_SARS2) Sequence A:  RKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVI CTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQ NCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPS GVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFCYMH HMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVN VLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLT QDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILG SALLEDEFTPFDVVRQCS Description Functional site 1) chain A residue 140 type sequence F description binding site for residue QYS A 401 source : AC1 2) chain A residue 142 type sequence N description binding site for residue QYS A 401 source : AC1 3) chain A residue 143 type sequence G description binding site for residue QYS A 401 source : AC1 4) chain A residue 144 type sequence S description binding site for residue QYS A 401 source : AC1 5) chain A residue 145 type sequence C description binding site for residue QYS A 401 source : AC1 6) chain A residue 163 type sequence H description binding site for residue QYS A 401 source : AC1 7) chain A residue 164 type sequence H description binding site for residue QYS A 401 source : AC1 8) chain A residue 165 type sequence M description binding site for residue QYS A 401 source : AC1 9) chain A residue 166 type sequence E description binding site for residue QYS A 401 source : AC1 10) chain A residue 172 type sequence H description binding site for residue QYS A 401 source : AC1 11) chain A residue 189 type sequence Q description binding site for residue QYS A 401 source : AC1 12) chain A residue 191 type sequence A description binding site for residue QYS A 401 source : AC1 13) chain A residue 41 type ACT_SITE sequence H description For 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772, ECO:0000305|PubMed:32198291 source Swiss-Prot : SWS_FT_FI1 14) chain A residue 145 type ACT_SITE sequence C description Nucleophile; for 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772, ECO:0000269|PubMed:32198291 source Swiss-Prot : SWS_FT_FI2

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