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eF-site ID
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6xdg-ABCDE |
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PDB Code
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6xdg |
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Chain
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A, B, C, D, E |
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click to enlarge
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Title
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Complex of SARS-CoV-2 receptor binding domain with the Fab fragments of two neutralizing antibodies |
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Classification
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VIRAL PROTEIN/IMMUNE SYSTEM |
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Compound
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Spike protein S1 |
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Source
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(6XDG) |
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Sequence
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A: |
ALTQPASVSGSPGQSITISCTGTSSDVGGYNYVSWYQQHP
GKAPKLMIYDVSKRPSGVSNRFSGSKSGNTASLTISGLQS
EDEADYYCNSLTSISTWVFGGGTKLTVLGQPKAAPSVTLF
PPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAG
VETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHE
GSTVEKTVAPT
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| B: |
QVQLVESGGGLVKPGGSLRLSCAASGFTFSDYYMSWIRQA
PGKGLEWVSYITYSGSTIYYADSVKGRFTISRDNAKSSLY
LQMNSLRAEDTAVYYCARDRGTTMVPFDYWGQGTLVTVSS
ASTKGPSVFPLAPTAALGCLVKDYFPEPVTVSWNSGALTS
GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHK
PSNTKVDKKVEP
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| C: |
QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYAMYWVRQA
PGKGLEWVAVISYDGSNKYYADSVKGRFTISRDNSKNTLY
LQMNSLRTEDTAVYYCASGSDYGDYLLVYWGQGTLVTVSS
ASTKGPSVFPLAPTAALGCLVKDYFPEPVTVSWNSGALTS
GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHK
PSNTKVDKKVEP
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| D: |
DIQMTQSPSSLSASVGDRVTITCQASQDITNYLNWYQQKP
GKAPKLLIYAASNLETGVPSRFSGSGSGTDFTFTISGLQP
EDIATYYCQQYDNLPLTFGGGTKVEIKRTVAAPSVFIFPP
SDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ
ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQG
LSSPVTKSFNRGEC
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| E: |
TNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSA
SFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAP
GQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYL
YRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPL
QSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCG
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Description
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(1) |
Spike glycoprotein, REGN10933 antibody Fab fragment light chain, REGN10933 antibody Fab fragment heavy chain, REGN10987 antibody Fab heavy chain, REGN10987 antibody Fab fragment light chain
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Functional site
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1)
|
chain |
E |
| residue |
343 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942
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| source |
Swiss-Prot : SWS_FT_FI3
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2)
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chain |
D |
| residue |
192-198 |
| type |
prosite |
| sequence |
YACEVTH
|
| description |
IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH
|
| source |
prosite : PS00290
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3)
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chain |
A |
| residue |
195-201 |
| type |
prosite |
| sequence |
YSCQVTH
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| description |
IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH
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| source |
prosite : PS00290
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4)
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chain |
C |
| residue |
201-207 |
| type |
prosite |
| sequence |
YICNVNH
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| description |
IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH
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| source |
prosite : PS00290
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5)
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chain |
B |
| residue |
201-207 |
| type |
prosite |
| sequence |
YICNVNH
|
| description |
IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH
|
| source |
prosite : PS00290
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