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eF-site ID
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6xc4-AHLXYZ |
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PDB Code
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6xc4 |
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Chain
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A, H, L, X, Y, Z |
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click to enlarge
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Title
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Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody CC12.3 |
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Classification
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IMMUNE SYSTEM/VIRAL PROTEIN |
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Compound
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Spike protein S1 |
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Source
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(6XC4) |
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Sequence
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A: |
NLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSAS
FSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPG
QTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLY
RLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQ
SYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTN
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| H: |
QVQLVESGGGLIQPGGSLRLSCAASGFTVSSNYMSWVRQA
PGKGLEWVSVIYSGGSTFYADSVKGRFTISRDNSKSTLYL
QMNSLRVEDTAVYYCARDFGDFYFDYWGQGTLVTVSSAST
KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNS
GALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYIC
NVNHKPSNTKVDKKVEPKSC
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| L: |
EIVLTQSPGTLSLSPGERATLSCRASQSVSSYLAWYQQKP
GQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEP
EDFAVYYCQQYGSSPRTFGQGTKLEIKRTVAAPSVFIFPP
SDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ
ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQG
LSSPVTKSFNRGE
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| X: |
QVQLVESGGGLIQPGGSLRLSCAASGFTVSSNYMSWVRQA
PGKGLEWVSVIYSGGSTFYADSVKGRFTISRDNSKSTLYL
QMNSLRVEDTAVYYCARDFGDFYFDYWGQGTLVTVSSAST
KGPSVFPLAPSSGTAALGCLVKDYFPEPVTVSWNSGALTS
GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHK
PSNTKVDKKVEPKS
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| Y: |
EIVLTQSPGTLSLSPGERATLSCRASQSVSSYLAWYQQKP
GQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEP
EDFAVYYCQQYGSSPRTFGQGTKLEIKRTVAAPSVFIFPP
SDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ
ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQG
LSSPVTKSFNRGE
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| Z: |
NLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSAS
FSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPG
QTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLY
RLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQ
SYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGP
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Description
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Functional site
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1)
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chain |
L |
| residue |
192-198 |
| type |
prosite |
| sequence |
YACEVTH
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| description |
IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH
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| source |
prosite : PS00290
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2)
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chain |
H |
| residue |
194-200 |
| type |
prosite |
| sequence |
YICNVNH
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| description |
IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH
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| source |
prosite : PS00290
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3)
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chain |
A |
| residue |
343 |
| type |
CARBOHYD |
| sequence |
N
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| description |
N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942
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| source |
Swiss-Prot : SWS_FT_FI3
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4)
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chain |
Z |
| residue |
343 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942
|
| source |
Swiss-Prot : SWS_FT_FI3
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