eF-site ID 6xbi-B PDB Code 6xbi Chain B click to enlarge Title Crystal structure of the SARS-CoV-2 (COVID-19) main protease in complex with inhibitor UAW248 Classification HYDROLASE/HYDROLASE INHIBITOR Compound 3C-like proteinase Source (6XBI) Sequence B:  HMSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYC PRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVI GHSMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACY NGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVS FCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDT TITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYN YEPLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNG RTILGSALLEDEFTPFDVVRQCSG Description Functional site 1) chain B residue 105 type sequence R description binding site for residue GOL A 501 source : AC1 2) chain B residue 107 type sequence Q description binding site for residue GOL A 501 source : AC1 3) chain B residue 228 type sequence N description binding site for residue GOL A 502 source : AC2 4) chain B residue 180 type sequence N description binding site for residue NA A 503 source : AC3 5) chain B residue 6 type sequence M description binding site for residue DMS B 501 source : AC4 6) chain B residue 7 type sequence A description binding site for residue DMS B 501 source : AC4 7) chain B residue 8 type sequence F description binding site for residue DMS B 501 source : AC4 8) chain B residue 298 type sequence R description binding site for residue DMS B 501 source : AC4 9) chain B residue 41 type ACT_SITE sequence H description For 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772, ECO:0000305|PubMed:32198291 source Swiss-Prot : SWS_FT_FI1 10) chain B residue 145 type ACT_SITE sequence C description Nucleophile; for 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772, ECO:0000269|PubMed:32198291 source Swiss-Prot : SWS_FT_FI2

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